amfAR, The Foundation for AIDS Research

Publications from amfAR Grantees and Fellows 2012

November 2012


Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY.
A Randomized Controlled Trial Assessing the Effects of Raltegravir Intensification on Endothelial Function in Treated HIV Infection.
J Acquir Immune Defic Syndr. 2012 Nov 1;61(3):317-25.


Nyoni J, Ross MW.
Factors associated with HIV testing in men who have sex with men, in Dar es Salaam, Tanzania.
Sex Transm Infect. 2012 Nov;88(7):483.
READ MORE: Increasing HIV Testing Among MSM in Africa


Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
AIDS. 2012 Nov 28;26(18):2295-2306.


Routy JP, Angel JB, Spaans JN, Trottier B, Rouleau D, Baril JG, Harris M, Trottier S, Singer J, Chomont N, Sékaly RP, Tremblay CL.
Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV Reservoir.
HIV Clin Trials. 2012 Nov-Dec;13(6):301-7.


October 2012


Schrijvers R, Vets S, De Rijck J Malani N, Bushman FD, Debyser Z, Gijsbers R.
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.
Retrovirology. 2012 Oct 9;9:84. doi: 10.1186/1742-4690-9-84.
READ MORE:  Exploring Potential New Targets for Anti-HIV Drugs  

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746.

Koh Fujinaga, Matjaz Barboric, Qintong Li, Zeping Luo, David H. Price and
B. Matija Peterlin.
PKC phosphorylates HEXIM1 and regulates P-TEFb activity.
Nucleic Acids Research, 2012, Vol. 40, No. 18: 9160-9170.
No abstract available


September 2012


Patel ES, Chang LJ.
Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling in Human T Cell Development.
J J Biol Chem. 2012 Sep 28;287(40):33826-35.


Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.
Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding.
J Virol. 2012 Sep;86(17):8974-86.


Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR.
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections.
J Virol. 2012 Sep;86(17):8920-36.
READ MORE: Potential Cures for Other Viral Infections


Praditpornsilpa K, Avihingsanon A, Chaiwatanarat T, Chaiyahong P, Wongsabut J, Ubolyam S, Chulakadabba A, Avihingsanon Y, Ruxrungtham K, Tunsanga K, Eiam-Ong S,
Phanuphak P.
Comparisons Between Validated Estimated Glomerular Filtration Rate Equations and Isotopic Glomerular Filtration Rate in HIV Patients.
J AIDS. 2012 Sep 10;26(14):1781-8.


Eisele E, Siliciano RF.
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication.
Immunity. 2012 Sep 21;37(3):377-88.



August 2012


Sigal A, Baltimore D.
As good as it gets? The problem of HIV persistence despite antiretroviral drugs.
Cell Host Microbe. 2012 Aug 16;12(2):132-8.


July 2012


Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S.
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.
J Infect Dis. 2012 Jul 1;206(1):28-34.
READ MORE: Defining HIV Reservoirs

Hogue IB, Llewellyn GN, Ono A.
Dynamic Association between HIV-1 Gag and Membrane Domains.
Mol Biol Int. 2012;2012:979765. Epub 2012 Jul 5.


May 2012


Merchant RC, Waxman MJ, Maher JG, Clark MA, Celada MT, Liu T, Simmons EM, Beckwith CG, Mayer KH.
Patient and Clinician Ethical Perspectives on the 2006 Centers for Disease Control and Prevention HIV Testing Methods.
Public Health Rep. 2012 May;127(3):318-29.
READ MORE: The Ethics of New HIV Testing Methods


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


April 2012


Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM.
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes Immun. 2012 Apr;13(3):258-67.


Gilchrist G, Blazquez A, Torrens, M.
Exploring the relationship between intimate partner violence, childhood abuse and psychiatric disorders among female drug users in Barcelona.
Advances in Dual Diagnosis. 2012 Apr;5(2):46-58.


Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.


Tun W, Kellerman S, Maimane S, Fipaza Z, Sheehy M, Vu L, Nel D.
HIV-related conspiracy beliefs and its relationships with HIV testing and unprotected sex among men who have sex with men in Tshwane (Pretoria), South Africa.
AIDS Care. 2012 Apr;24(4):459-67.
READ MORE: Homophobia and the Spread of HIV in South Africa


Vu L, Tun W, Sheehy M, Nel D.
Levels and correlates of internalized homophobia among men who have sex with men in Pretoria, South Africa.
AIDS Behav. 2012 Apr;16(3):717-23.
READ MORE: Homophobia and the Spread of HIV in South Africa


March 2012

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.
LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs.
PLoS Pathog. 2012 Mar;8(3):e1002558.


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


Melchers M, Bontjer I, Tong T, Chung NP, Klasse PJ, Eggink D, Montefiori DC, Gentile M, Cerutti A, Olson WC, Berkhout B, Binley JM, Moore JP, Sanders RW.
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
J Virol. 2012 Mar;86(5):2488-500.


Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF.
Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation.
immunity. 2012 Mar 23;36(3):491-501.
READ MORE: Destroying HIV Reservoirs


Tyagi M, Kashanchi F.
New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.
Retrovirology. 2012 Mar 9;9:19.



February 2012


Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T, Yokoyama S, Aiken C, Diaz-Griffero F.
RING domain mutations uncouple TRIM5a restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.
J Virol. 2012 Feb;86(3):1717-27.


Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F.
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Nat Immunol. 2012 Feb 12;13(3):223-8.


Kiem HP, Jerome KR, Deeks SG, McCune JM.
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Cell Stem Cell. 2012 Feb 3;10(2):137-47.
READ MORE: Leading the Charge in Cure Research


Banerjee K, Michael E, Eggink D, van Montfort T, Lasnik AB, Palmer KE, Sanders RW, Moore JP, Klasse PJ.
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice.
AIDS Res Hum Retroviruses. 2012 Feb;28(2):206-14.


Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF.
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
J Antimicrob Chemother. 2012 Feb;67(2):398-403.
READ MORE: Leading the Charge in Cure Research



January 2012


Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV.
Generation of HIV latency in humanized BLT mice.
J Virol. 2012 Jan;86(1):630-4.


Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, Kodama EI, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res. 2012 Jan 1;40(1):345-359.


Routy J, Tremblay C, Angel J, Trottier B, Rouleau D, Baril J, Harris M, Trottier S, Singer J, Chomont N, Sékaly R, Boulassel M.
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.
HIV Med. 2012 Jan 26.
READ MORE: “Shock and Kill” Strategy Holds Promise in the Search for a Cure


Boulassel MR, Chomont N, Pai NP, Gilmore N, Sékaly RP, Routy JP.
CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.
J Clin Virol. 2012 Jan;53(1):29-32.