Publications from amfAR Grantees and Fellows (2013 - 2012)

Click here for publications prior to 2012.

Publications of amfAR Grantees and Fellows

Introduction

Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff.

May 2013

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS Pathog. 2013 May;9(5):e1003347.
ABSTRACT

Vandergeeten C, Fromentin R, Dafonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sékaly RP, Chomont N.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Blood. 2013 May 23;121(21):4321-9.
ABSTRACT

Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription.
J Biol Chem. 2013 May 17;288(20):14400-7.
ABSTRACT

Hatano H.
Immune activation and HIV persistence: considerations for novel therapeutic interventions.
Curr Opin HIV AIDS. 2013 May;8(3):211-6.
ABSTRACT

Stone D, Kiem HP, Jerome KR.
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS. 2013 May;8(3):217-23.
ABSTRACT

Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ.
Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection.
PLoS One. 2013 May 6;8(5):e61383.
ABSTRACT

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes.
PLoS Pathog. 2013 May;9(5):e1003338
ABSTRACT

April 2013

McNatt MW, Zang T, Bieniasz PD.
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathog. 2013 Apr;9(4):e1003299.
ABSTRACT

Voit RA, McMahon MA, Sawyer SL, Porteus MH.
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Mol Ther. 2013 Apr;21(4):786-95
ABSTRACT
READ MORE: Stopping HIV Using a Cocktail of Genes Rather than Drugs

March 2013

Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
J Virol. 2013 Mar;87(5):2549-62.
ABSTRACT

Kutluay SB, Perez-Caballero D, Bieniasz PD.
Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection.
PLoS Pathog. 2013 Mar;9(3):e1003214.
ABSTRACT

Palmer S.
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92.
ABSTRACT
READ MORE: Perfecting Tools to Monitor HIV Viral Loads

February 2013

Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM.
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res Hum Retroviruses. 2013 Feb;29(2):207-14.
ABSTRACT
READ MORE: Keeping Track of HIV Reservoirs

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies.
PLoS Pathog. 2013 Feb;9(2):e1003174.
ABSTRACT
READ MORE: Keeping Track of HIV Reservoirs

January 2013

Ross MW, Nyoni J, Bowen AM, Williams ML, Kashiha JJ.
Sexual and geographic organization of men who have sex with men in a large East African city: opportunities for outreach.
BMJ Open. 2012 Nov 22;2(6) e001813.
ABSTRACT

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ. Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
J Infect Dis. 2013 Jan; 207(2):213-22.
ABSTRACT
READ MORE: Controlling HIV After Stopping Antiretroviral Therapy

November 2012

Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY.
A Randomized Controlled Trial Assessing the Effects of Raltegravir Intensification on Endothelial Function in Treated HIV Infection.
J Acquir Immune Defic Syndr. 2012 Nov 1;61(3):317-25.
ABSTRACT

Nyoni J, Ross MW.
Factors associated with HIV testing in men who have sex with men, in Dar es Salaam, Tanzania.
Sex Transm Infect. 2012 Nov;88(7):483.
ABSTRACT
READ MORE: Increasing HIV Testing Among MSM in Africa

Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
AIDS. 2012 Nov 28;26(18):2295-2306.
ABSTRACT

Routy JP, Angel JB, Spaans JN, Trottier B, Rouleau D, Baril JG, Harris M, Trottier S, Singer J, Chomont N, Sékaly RP, Tremblay CL.
Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV Reservoir.
HIV Clin Trials. 2012 Nov-Dec;13(6):301-7.
ABSTRACT

October 2012

Schrijvers R, Vets S, De Rijck J Malani N, Bushman FD, Debyser Z, Gijsbers R.
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology. 2012 Oct 9;9:84. doi: 10.1186/1742-4690-9-84.

September 2012

Patel ES, Chang LJ.
Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling in Human T Cell Development.
J J Biol Chem. 2012 Sep 28;287(40):33826-35.
ABSTRACT

Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.
Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding.
J Virol. 2012 Sep;86(17):8974-86.
ABSTRACT

Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR.
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections.
J Virol. 2012 Sep;86(17):8920-36.
ABSTRACT
READ MORE: Potential Cures for Other Viral Infections

Praditpornsilpa K, Avihingsanon A, Chaiwatanarat T, Chaiyahong P, Wongsabut J, Ubolyam S, Chulakadabba A, Avihingsanon Y, Ruxrungtham K, Tunsanga K, Eiam-Ong S,
Phanuphak P.
Comparisons Between Validated Estimated Glomerular Filtration Rate Equations and Isotopic Glomerular Filtration Rate in HIV Patients.
J AIDS. 2012 Sep 10;26(14):1781-8.
ABSTRACT

Eisele E, Siliciano RF.
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication.
Immunity. 2012 Sep 21;37(3):377-88.
ABSTRACT

July 2012

Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S.
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.
J Infect Dis. 2012 Jul 1;206(1):28-34.
ABSTRACT
READ MORE: Defining HIV Reservoirs

Hogue IB, Llewellyn GN, Ono A.
Dynamic Association between HIV-1 Gag and Membrane Domains.
Mol Biol Int. 2012;2012:979765. Epub 2012 Jul 5.
ABSTRACT

May 2012

Merchant RC, Waxman MJ, Maher JG, Clark MA, Celada MT, Liu T, Simmons EM, Beckwith CG, Mayer KH.
Patient and Clinician Ethical Perspectives on the 2006 Centers for Disease Control and Prevention HIV Testing Methods.
Public Health Rep. 2012 May;127(3):318-29.
ABSTRACT
READ MORE: The Ethics of New HIV Testing Methods

McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.
ABSTRACT

April 2012

Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM.
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes Immun. 2012 Apr;13(3):258-67.
ABSTRACT

Gilchrist G, Blazquez A, Torrens, M.
Exploring the relationship between intimate partner violence, childhood abuse and psychiatric disorders among female drug users in Barcelona.
Advances in Dual Diagnosis. 2012 Apr;5(2):46-58.

Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.
ABSTRACT

Tun W, Kellerman S, Maimane S, Fipaza Z, Sheehy M, Vu L, Nel D.
HIV-related conspiracy beliefs and its relationships with HIV testing and unprotected sex among men who have sex with men in Tshwane (Pretoria), South Africa.
AIDS Care. 2012 Apr;24(4):459-67.
ABSTRACT
READ MORE: Homophobia and the Spread of HIV in South Africa

Vu L, Tun W, Sheehy M, Nel D.
Levels and correlates of internalized homophobia among men who have sex with men in Pretoria, South Africa.
AIDS Behav. 2012 Apr;16(3):717-23.
ABSTRACT
READ MORE: Homophobia and the Spread of HIV in South Africa

March 2012

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.
LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs.
PLoS Pathog. 2012 Mar;8(3):e1002558.
ABSTRACT

McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.
ABSTRACT

Melchers M, Bontjer I, Tong T, Chung NP, Klasse PJ, Eggink D, Montefiori DC, Gentile M, Cerutti A, Olson WC, Berkhout B, Binley JM, Moore JP, Sanders RW.
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
J Virol. 2012 Mar;86(5):2488-500.
ABSTRACT

Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF.
Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation.
immunity. 2012 Mar 23;36(3):491-501.
ABSTRACT
READ MORE: Destroying HIV Reservoirs

Tyagi M, Kashanchi F.
New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.
Retrovirology. 2012 Mar 9;9:19.
ABSTRACT

February 2012

Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T, Yokoyama S, Aiken C, Diaz-Griffero F.
RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.
J Virol. 2012 Feb;86(3):1717-27.
ABSTRACT

Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F.
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Nat Immunol. 2012 Feb 12;13(3):223-8.
ABSTRACT

Kiem HP, Jerome KR, Deeks SG, McCune JM.
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Cell Stem Cell. 2012 Feb 3;10(2):137-47.
ABSTRACT
READ MORE: Leading the Charge in Cure Research

Banerjee K, Michael E, Eggink D, van Montfort T, Lasnik AB, Palmer KE, Sanders RW, Moore JP, Klasse PJ.
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice.
AIDS Res Hum Retroviruses. 2012 Feb;28(2):206-14.
ABSTRACT

Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF.
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
J Antimicrob Chemother. 2012 Feb;67(2):398-403.
ABSTRACT
READ MORE: Leading the Charge in Cure Research

January 2012

Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV.
Generation of HIV latency in humanized BLT mice.
J Virol. 2012 Jan;86(1):630-4.
ABSTRACT

Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, Kodama EI, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res. 2012 Jan 1;40(1):345-359.
ABSTRACT

Routy J, Tremblay C, Angel J, Trottier B, Rouleau D, Baril J, Harris M, Trottier S, Singer J, Chomont N, Sékaly R, Boulassel M.
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.
HIV Med. 2012 Jan 26.
ABSTRACT
READ MORE: “Shock and Kill” Strategy Holds Promise in the Search for a Cure

Boulassel MR, Chomont N, Pai NP, Gilmore N, Sékaly RP, Routy JP.
CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.
J Clin Virol. 2012 Jan;53(1):29-32.
ABSTRACT