Publications from amfAR Grantees and Fellows
INTRODUCTION
Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff.
2010 PUBLICATIONS
June 2010
Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.
Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.
J Biol Chem. 2010 Jun 25;285(26):20303-15.
ABSTRACT
Javanbakht M, Guerry S, Gorbach PM, Stirland A, Chien M, Anton P, Kerndt PR.
Prevalence and correlates of heterosexual anal intercourse among clients attending public sexually transmitted disease clinics in Los Angeles County.
Sex Transm Dis. 2010 Jun;37(6):369-76.
ABSTRACT
Eggink D, Melchers M, Wuhrer M, van Montfort T, Dey AK, Naaijkens BA, David KB, Le Douce V, Deelder AM, Kang K, Olson WC, Berkhout B, Hokke CH, Moore JP, Sanders RW.
Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function.
Virology. 2010 Jun 5;401(2):236-47.
ABSTRACT
Binley JM, Ban YE, Crooks ET, Eggink D, Osawa K, Schief WR, Sanders RW.
Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization.
J Virol. 2010 Jun;84(11):5637-55.
ABSTRACT
May 2010
Owen RE, Heitman JW, Hirschkorn DF, Lanteri MC, Biswas HH, Martin JN, Krone MR, Deeks SG, Norris PJ; NIAID Center for HIV/AIDS Vaccine Immunology.
HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.
AIDS. 2010 May 15;24(8):1095-105.
ABSTRACT
Götte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF.
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochim Biophys Acta. 2010 May;1804(5):1202-12.
ABSTRACT
READ MORE: New Insights into Old Drug Classes
April 2010
Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS.
Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
AIDS. 2010 Apr 24;24(7):1001-5.
ABSTRACT
Deretic V.
Autophagy in infection.
Curr Opin Cell Biol. 2010 Apr;22(2):252-62.
ABSTRACT
Buzón MJ, Massanella M, Llibre JM, Esteve A, Dahl V, Puertas MC, Gatell JM, Domingo P, Paredes R, Sharkey M, Palmer S, Stevenson M, Clotet B, Blanco J, Martinez-Picado J.
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.
Nat Med. 2010 Apr;16(4):460-5.
ABSTRACT
READ MORE: Reducing HIV Growth to Zero
MARCH 2010
Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VN.
Flexible use of nuclear import pathways by HIV-1.
Cell Host Microbe. 2010 Mar 18;7(3):221-33.
ABSTRACT
READ MORE: Keeping HIV Out of a Cell’s Nucleus
Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman FD, Debyser Z.
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.
Mol Ther. 2010 Mar;18(3):552-60.
ABSTRACT
Ono A.
Relationships between plasma membrane microdomains and HIV-1 assembly.
Biol Cell. 2010 Mar 25;102(6):335-50.
ABSTRACT
Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M.
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Cell Host Microbe. 2010 Mar 18;7(3):234-44.
ABSTRACT
February 2010
Gosselin A, Monteiro P, Chomont N, Diaz-Griffero F, Said EA, Fonseca S, Wacleche V, El-Far M, Boulassel MR, Routy JP, Sekaly RP, Ancuta P.
Peripheral blood CCR4+ CCR6+ and CXCR3+ CCR6+ CD4+ T cells are highly permissive to HIV-1 infection.
J Immunol. 2010 Feb 1;184(3):1604-16.
ABSTRACT
READ MORE: Defining the Key Targets of HIV Infection
January 2010
Ances BM, Greenberg JH, Detre JA.
Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
Brain Res. 2010 Jan 14;1309:19-28.
ABSTRACT
Denton PW, Krisko JF, Powell DA, Mathias M, Kwak YT, Martinez-Torres F, Zou W, Payne DA, Estes JD, Garcia JV.
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.
PLoS One. 2010 Jan 21;5(1):e8829.
ABSTRACT
READ MORE: The Promise of PrEP: Using Antiretrovirals to Prevent HIV Infection
2009 PUBLICATIONS
DECEMBER 2009
Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG.
Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
J Biol Chem. 2009 Dec 18;284(51):35681-91.
ABSTRACT
READ MORE: Surprising Keys to a New Anti-HIV Compound
November 2009
Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE.
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.
Retrovirology. 2009 Nov 4;6:101.
ABSTRACT
READ MORE: Animal Model Enables Researchers to Track the Evolution of HIV
Jouvenet N, Simon SM, Bieniasz PD.
Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles.
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19114-9.
ABSTRACT
October 2009
Choi AI, Shlipak MG, Hunt PW, Martin JN, Deeks SG.
HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy.
AIDS. 2009 Oct 23;23(16):2143-9.
ABSTRACT
READ MORE: HIV, HAART, and the Kidneys
Diaz-Griffero F, Qin XR, Hayashi F, Kigawa T, Finzi A, Sarnak Z, Lienlaf M, Yokoyama S, Sodroski J.
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.
J Virol. 2009 Oct;83(20):10737-51.
ABSTRACT
Liu H, Feng T, Liu H, Feng H, Cai Y, Rhodes AG, Grusky O.
Egocentric networks of Chinese men who have sex with men: network components, condom use norms, and safer sex.
AIDS Patient Care STDS. 2009 Oct;23(10):885-93.
ABSTRACT
Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M.
Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.
J Virol. 2009 Oct;83(19):9694-708.
ABSTRACT
Sayles JN, Wong MD, Kinsler JJ, Martins D, Cunningham WE.
The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV/AIDS.
J Gen Intern Med. 2009 Oct;24(10):1101-8.
ABSTRACT
SEPTEMBER 2009
Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, Buxton RB, Benson D, Smith DM, Little SJ, Richman DD, Moore DJ, Ellis RJ; HNRC group.
Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain.
Neurology. 2009 Sep 1;73(9):702-8.
ABSTRACT
Archin NM, Keedy KS, Espeseth A, Dang H, Hazuda DJ, Margolis DM.
Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors.
AIDS. 2009 Sep 10;23(14):1799-806.
ABSTRACT
READ MORE: In Search of a Cure: Working to Turn On HIV
Eggink D, Langedijk JP, Bonvin AM, Deng Y, Lu M, Berkhout B, Sanders RW.
Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.
J Biol Chem. 2009 Sep 25;284(39):26941-50.
ABSTRACT
Shehu-Xhilaga M, Rhodes D, Wightman F, Liu HB, Solomon A, Saleh S, Dear AE, Cameron PU, Lewin SR.
The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.
AIDS. 2009 Sep 24;23(15):2047-50.
ABSTRACT
READ MORE: In Search of a Cure: Working to Turn On HIV
August 2009
Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.
Nat Med. 2009 Aug;15(8):893-900.
ABSTRACT
READ MORE: Eradicating HIV—amfAR-Funded Researchers Shed New Light on HIV Persistence
Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC.
HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.
PLoS One. 2009 Aug 7;4(8):e6551.
ABSTRACT
Liu H, Liu H, Cai Y, Rhodes AG, Hong F.
Money boys, HIV risks, and the associations between norms and safer sex: a respondent-driven sampling study in Shenzhen, China.
AIDS Behav. 2009 Aug;13(4):652-62.
ABSTRACT
READ MORE: Money Boys and the Spread of HIV in China
July 2009
Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V.
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
J Cell Biol. 2009 Jul 27;186(2):255-68.
ABSTRACT
Jin J, Sherer NM, Heidecker G, Derse D, Mothes W.
Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.
PLoS Biol. 2009 Jul;7(7):e1000163.
ABSTRACT
June 2009
Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, Martin JN, Deeks SG.
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.
AIDS. 2009 Jun 1;23(9):1059-67.
ABSTRACT
READ MORE: HIV, HAART, and the Heart
Deretic V, Levine B.
Autophagy, immunity, and microbial adaptations.
Cell Host Microbe. 2009 Jun 18;5(6):527-49.
ABSTRACT
May 2009
Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK.
Host cell factors in HIV replication: meta-analysis of genome-wide studies.
PLoS Pathog. 2009 May;5(5):e1000437.
ABSTRACT
Ince WL, Harrington PR, Schnell GL, Patel-Chhabra M, Burch CL, Menezes P, Price RW, Eron JJ Jr, Swanstrom RI.
Major coexisting human immunodeficiency virus type 1 env gene subpopulations in the peripheral blood are produced by cells with similar turnover rates and show little evidence of genetic compartmentalization.
J Virol. 2009 May;83(9):4068-80.
ABSTRACT
Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ.
Reverse transcriptase inhibitors as potential colorectal microbicides.
Antimicrob Agents Chemother. 2009 May;53(5):1797-807.
ABSTRACT
READ MORE: Studying and Stopping Rectal Transmission of HIV
Keele BF, Li H, Learn GH, Hraber P, Giorgi EE, Grayson T, Sun C, Chen Y, Yeh WW, Letvin NL, Mascola JR, Nabel GJ, Haynes BF, Bhattacharya T, Perelson AS, Korber BT, Hahn BH, Shaw GM.
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
J Exp Med. 2009 May 11;206(5):1117-34.
ABSTRACT
READ MORE: Studying and Stopping Rectal Transmission of HIV
April 2009
Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB.
Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation.
Hum Brain Mapp. 2009 Apr;30(4):1120-32.
ABSTRACT
Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control.
Blood. 2009 Apr 23;113(17):3978-89.
ABSTRACT
Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH, Athreya GS, Treurnicht FK, Keele BF, Wood N, Salazar-Gonzalez JF, Bhattacharya T, Chu H, Hoffman I, Galvin S, Mapanje C, Kazembe P, Thebus R, Fiscus S, Hide W, Cohen MS, Karim SA, Haynes BF, Shaw GM, Hahn BH, Korber BT, Swanstrom R, Williamson C; CAPRISA Acute Infection Study Team; Center for HIV-AIDS Vaccine Immunology Consortium.
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.
J Virol. 2009 Apr;83(8):3556-67.
ABSTRACT
Loh L, Reece JC, Fernandez CS, Alcantara S, Center R, Howard J, Purcell DF, Balamurali M, Petravic J, Davenport MP, Kent SJ.
Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.
PLoS Pathog. 2009 Apr;5(4):e1000378.
ABSTRACT
Lassen KG, Lobritz MA, Bailey JR, Johnston S, Nguyen S, Lee B, Chou T, Siliciano RF, Markowitz M, Arts EJ.
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
PLoS Pathog. 2009 Apr;5(4):e1000377.
ABSTRACT
Meade CS, Hansen NB, Kochman A, Sikkema KJ.
Utilization of medical treatments and adherence to antiretroviral therapy among HIV-positive adults with histories of childhood sexual abuse.
AIDS Patient Care STDS. 2009 Apr;23(4):259-66.
ABSTRACT
READ MORE: Optimizing Adherence in Adult Survivors of Childhood Sexual Abuse
March 2009
Hatziioannou T, Ambrose Z, Chung NP, Piatak M Jr, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD.
A macaque model of HIV-1 infection.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4425-9.
ABSTRACT
READ MORE: Monkeying Around With Genes Leads to Effective Simian Model
D'Orso I, Frankel AD.
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex.
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3101-6.
ABSTRACT
Huthoff H, Autore F, Gallois-Montbrun S, Fraternali F, Malim MH.
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.
PLoS Pathog. 2009 Mar;5(3):e1000330.
ABSTRACT
february 2009
Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y, McNatt M, Hatziioannou T, Bieniasz PD.
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.
J Virol. 2009 Feb;83(4):1837-44.
ABSTRACT
READ MORE: Tying Up HIV With Tetherin
Liu H, Feng T, Rhodes AG, Liu H.
Assessment of the Chinese version of HIV and homosexuality related stigma scales.
Sex Transm Infect. 2009 Feb;85(1):65-9.
ABSTRACT
JANUARY 2009
Haaland RE, Hawkins PA, Salazar-Gonzalez J, Johnson A, Tichacek A, Karita E, Manigart O, Mulenga J, Keele BF, Shaw GM, Hahn BH, Allen SA, Derdeyn CA, Hunter E.
Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.
PLoS Pathog. 2009 Jan;5(1):e1000274.
ABSTRACT
Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E.
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
J Mol Biol. 2009 Jan 23;385(3):693-713.
ABSTRACT
Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D.
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.
Cell Host Microbe. 2009 Jan 22;5(1):84-94.
ABSTRACT
READ MORE: The Promise of an Effective Vaginal Microbicide
Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW.
Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.
J Virol. 2009 Jan;83(1):368-83.
ABSTRACT
2008 PUBLICATIONS
December 2008
Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J.
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency.
J Virol. 2008 Dec;82(24):12291-303.
ABSTRACT
Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF.
RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.
J Virol. 2008 Dec;82(24):12145-53.
ABSTRACT
NOVEMBER 2008
Sanders RW, Hsu ST, van Anken E, Liscaljet IM, Dankers M, Bontjer I, Land A, Braakman I, Bonvin AM, Berkhout B.
Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.
Mol Biol Cell. 2008 Nov;19(11):4707-16.
ABSTRACT
OCTOBER 2008
Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D, Su L.
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.
Blood. 2008 Oct 1;112(7):2858-68.
ABSTRACT
READ MORE: Of Mice and Men: Using “Humanized” Mice to Fight HIV
SEPTEMBER 2008
Diaz-Griffero F, Perron M, McGee-Estrada K, Hanna R, Maillard PV, Trono D, Sodroski J.
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
Virology. 2008 Sep 1;378(2):233-42.
ABSTRACT
Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and psychometric assessment of a multidimensional measure of internalized HIV stigma in a sample of HIV-positive adults.
AIDS Behav. 2008 Sep;12(5):748-58.
ABSTRACT
READ MORE: Measuring Stigma in HIV/AIDS
AUGUST 2008
Zhang L, Li X, Ma J, Yu L, Jiang J, Cen S.
The incorporation of APOBEC3 proteins into murine leukemia viruses.
Virology. 2008 Aug 15;378(1):69-78.
ABSTRACT
Mahajan AP, Sayles JN, Patel VA, Remien RH, Sawires SR, Ortiz DJ, Szekeres G, Coates TJ.
Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward.
AIDS. 2008 Aug;22 Suppl 2:S67-79.
ABSTRACT
READ MORE: Stigma and the “Spoiled Identity”
JULY 2008
Jouvenet N, Bieniasz PD, Simon SM.
Imaging the biogenesis of individual HIV-1 virions in live cells.
Nature. 2008 Jul 10;454(7201):236-40.
ABSTRACT
READ MORE: Mathilde Krim Fellow Makes Breakthrough Finding - Podcast
Liu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y, Goepfert PA, Santiago ML, Ndjango JB, Neel C, Clifford SL, Sanz C, Kamenya S, Wilson ML, Pusey AE, Gross-Camp N, Boesch C, Smith V, Zamma K, Huffman MA, Mitani JC, Watts DP, Peeters M, Shaw GM, Switzer WM, Sharp PM, Hahn BH.
Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.
PLoS Pathog. 2008 Jul 4;4(7):e1000097.
ABSTRACT
READ MORE: Watch the Monkeys: Screening for New Retrovirus Outbreaks
Eggink D, Baldwin CE, Deng Y, Langedijk JP, Lu M, Sanders RW, Berkhout B.
Selection of T1249-resistant human immunodeficiency virus type 1 variants.
J Virol. 2008 Jul;82(13):6678-88.
ABSTRACT
JUNE 2008
Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF.
Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.
J Virol. 2008 Jun;82(11):5548-61.
ABSTRACT
Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG.
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
J Virol. 2008 Jun;82(11):5398-407.
ABSTRACT
Unwalla HJ, Li H, Li SY, Abad D, Rossi JJ.
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.
Mol Ther. 2008 Jun;16(6):1113-9.
ABSTRACT
READ MORE: Attacking HIV Genetically
MAY 2008
Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM.
HIV-induced changes in T cell signaling pathways.
J Immunol. 2008 May 15;180(10):6490-500.
ABSTRACT
READ MORE: Dialing Down the T Cell
Des Jarlais DC.
Data and Public Health Decision Making on HIV Prevention in Injection Drug Users
J Urban Health. 2008 May; 85(3): 303–305.
ABSTRACT
Groot F, Welsch S, Sattentau QJ.
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
Blood. 2008 May 1;111(9):4660-3.
ABSTRACT
APRIL 2008
Chiu YL, Greene WC.
The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements.
Annu Rev Immunol. 2008 Apr;26:317-353.
ABSTRACT
Diaz-Griffero F, Taube R, Muehlbauer SM, Brojatsch J.
Efficient production of HIV-1 viral-like particles in mouse cells.
Biochem Biophys Res Commun. 2008 Apr 11;368(3):463-9.
ABSTRACT
Benferhat R, Sanchez-Martinez S, Nieva JL, Briand JP, Hovanessian AG.
The immunogenic CBD1 peptide corresponding to the caveolin-1 binding domain in HIV-1 envelope gp41 has the capacity to penetrate the cell membrane and bind caveolin-1.
Mol Immunol. 2008 Apr;45(7):1963-75.
ABSTRACT
Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau KL, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG.
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.
J Virol. 2008 Apr;82(8):4154-8.
ABSTRACT
READ MORE: Stopping Sexual Transmission of HIV
Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and Psychometric Assessment of a Multidimensional Measure of Internalized HIV Stigma in a Sample of HIV-positive Adults.
AIDS Behav. 2008 Apr 4.
ABSTRACT
MARCH 2008
van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP.
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.
Nat Med. 2008 Mar;14(3):266-74.
ABSTRACT
READ MORE: Controlling HIV, Naturally
FEBRUARY 2008
Lakhashe S, Tripathy S, Paranjape R, Bhattacharya J.
Evidence of a Novel B/C Recombinant Exhibiting Unique Breakpoints of Near Full-Length HIV Type 1 Genome from Northeastern India.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):229-34.
ABSTRACT
READ MORE: Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance
Troyer RM, Lalonde MS, Fraundorf E, Demers KR, Kyeyune F, Mugyenyi P, Syed A, Whalen CC, Bajunirwe F, Arts EJ.
A Radiolabeled Oligonucleotide Ligation Assay Demonstrates the High Frequency of Nevirapine Resistance Mutations in HIV Type 1 Quasispecies of NVP-Treated and Untreated Mother-Infant Pairs from Uganda.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):235-50.
ABSTRACT
READ MORE: Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance
JANUARY 2008
Zhang L, Saadatmand J, Li X, Guo F, Niu M, Jiang J, Kleiman L, Cen S.
Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradation.
Virology. 2008 Jan 5;370(1):113-21.
ABSTRACT
READ MORE: Man (and Woman) Versus Virus
Kerns JA, Emerman M, Malik HS.
Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.
PLoS Genet. 2008 Jan;4(1):e21.
ABSTRACT
READ MORE: Man (and Woman) Versus Virus
2007 PUBLICATIONS
DECEMBER 2007
Sawyer SL, Emerman M, Malik HS.
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals.
PLoS Pathog. 2007 Dec 21;3(12):e197
ABSTRACT
Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU, Lewin SR.
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.
Blood. 2007 Dec 15;110(13):4161-4.
ABSTRACT
READ MORE: New Insights into HIV Latency: Identifying Roadblocks to a Cure
NOVEMBER 2007
Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M Jr, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.
Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1
Drug Resistance in a Macaque Model for Antiretroviral Therapy
J. Virol. 2007;81 12145-12155
ABSTRACT
Chen P, Hübner W, Spinelli MA, Chen BK.
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.
J Virol. 2007 Nov;81(22):12582-95.
ABSTRACT
Hübner W, Chen P, Del Portillo A, Liu Y, Gordon RE, Chen BK.
Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1.
J Virol. 2007 Nov;81(22):12596-607.
ABSTRACT
CA McKnight, DC Des Jarlais, T Perlis, K Eigo, M Krim, M Ruiz, D Purchase, A Solberg, TD Mastro.
Syringe Exchange Programs --- United States, 2005.
MMWR, November 9, 2007 / 56(44);1164-1167.
ABSTRACT
READ MORE: Syringe Exchange Programs: A Key Component of HIV Prevention
Song C, Aiken C.
Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.
J Virol. 2007 Nov;81(21):11946-56.
ABSTRACT
OCTOBER 2007
Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
EMBO J. 2007 Oct 3;26(19):4215-27.
ABSTRACT
Huffam S, Srasuebkul P, Zhou J, Calmy A, Saphonn V, Kaldor J, Ditangco R; on behalf of The TREAT Asia HIV Observational Database (TAHOD).
Prior antiretroviral therapy experience protects against zidovudine-related anaemia.
HIV Med. 2007 Oct;8(7):465-71.
ABSTRACT
READ MORE: Treating HIV/AIDS in Asia: Insights from amfAR's TREAT Asia Initiative
Voronin Y, Chohan B, Emerman M, Overbaugh J.
Primary isolates of human immunodeficiency virus type 1 are usually dominated by the major variants found in blood.
J Virol. 2007 Oct;81(19):10232-41.
ABSTRACT
SEPTEMBER 2007
Roc AC, Ances BM, Chawla S, Korczykowski M, Wolf RL, Kolson DL, Detre JA, Poptani H.
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Arch Neurol. 2007 Sep;64(9):1249-57.
ABSTRACT
READ MORE: Scanning the Brain
Dames SA, Schönichen A, Schulte A, Barboric M, Peterlin BM, Grzesiek S, Geyer M.
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14312-14317
ABSTRACT
Gorry PR, McPhee DA, Verity E, Dyer WB, Wesselingh SL, Learmont J, Sullivan JS, Roche M, Zaunders JJ, Gabuzda D, Crowe SM, Mills J, Lewin SR, Brew BJ, Cunningham AL, Churchill MJ.
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo.
Retrovirology. 2007 Sep 23;4(1):66
ABSTRACT
Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.
Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host.
J Immunol. 2007 Sep 1;179(5):3047-56.
ABSTRACT
Neil S.J.D, Sandrin V., Sundquist W.I., Bieniasz P.
An interferon-alpha induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by HIV-1 Vpu protein.
Cell Host & Microbe. (2007), Sep 2(3):193–203.
ABSTRACT
Simon Swingler, Angela M. Mann, Jin Zhou, Catherine Swingler, Mario Stevenson
Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein
PLoS Pathog 2007 3(9): e134
ABSTRACT
Srasuebkul P, Calmy A, Zhou J, Kumarasamy N, Law M, Lim PL.
Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in The TREAT Asia HIV Observational Database (TAHOD).
AIDS Res Ther. 2007 Sep 17;4(1):18
ABSTRACT
AUGUST 2007
Bellamy-McIntyre AK, Lay CS, Baär S, Maerz AL, Talbo GH, Drummer HE, Poumbourios P.
Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion.
J Biol Chem. 2007 Aug 10;282(32):23104-16.
ABSTRACT
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets
Pastore C, Nedellec R, Ramos A, Hartley O, Miamidian JL, Reeves JD, Mosier DE.
Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching.
J Virol. 2007 Aug;81(15):8165-79.
ABSTRACT
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets
Zhou J, Dore GJ, Zhang F, Lim PL, Chen YM; The TREAT Asia HIV Observational Database.
Hepatitis B and C virus coinfection in The TREAT Asia HIV Observational Database.
J Gastroenterol Hepatol. 2007 Aug 15;22(9):1510-1518.
ABSTRACT
JULY 2007
Berthoux L, Sebastian S, Muesing MA, Luban J.
The role of lysine 186 in HIV-1 integrase multimerization.
Virology. 2007 Jul 20;364(1):227-36.
ABSTRACT
Gray L, Churchill MJ, Sterjovski J, Witlox K, Learmont JC, Sullivan JS, Wesselingh SL, Gabuzda D, Cunningham AL, McPhee DA, Gorry PR.
Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source.
Virol J. 2007 Jul 16;4(1):75
ABSTRACT
READ MORE: Long-Term Survivors of HIV
Zhou J, Paton NI, Ditangco R; The TREAT Asia HIV Observational Database.
AIDS-defining illness diagnosed within 90 days after starting highly active antiretroviral therapy among patients from the TREAT Asia HIV Observational Database.
Int J STD AIDS. 2007 Jul;18(7):446-52.
ABSTRACT
Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
Identification of Human MVB12 Proteins as ESCRT-I Subunits that Function in HIV Budding.
Cell Host & Microbe 2007 Jul 2(1): 41-53
ABSTRACT
JUNE 2007
Mowry EM, Woo JH, Ances BM.
Baló's concentric sclerosis presenting as a stroke-like syndrome.
Nat Clin Pract Neurol. 2007 Jun;3(6):349-54.
ABSTRACT
Sailaja G, Skountzou I, Quan FS, Compans RW, Kang SM.
Human immunodeficiency virus-like particles activate multiple types of immune cells.
Virology. 2007 Jun 5;362(2):331-41.
ABSTRACT
READ MORE: Envisioning an AIDS Vaccine
Coskun AK, van Maanen M, Janka D, Stockton D, Stankiewicsz P, Yatsenko S, Sutton RE.
Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release.
Virology. 2007 Jun 5;362(2):283-93.
ABSTRACT
MAY 2007
Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Virology. 2007 May 25;362(1):163-78.
ABSTRACT
Ellery PJ, Tippett E, Chiu YL, Paukovics G, Cameron PU, Solomon A, Lewin SR, Gorry PR, Jaworowski A, Greene WC, Sonza S, Crowe SM.
The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.
J Immunol. 2007 May 15;178(10):6581-9.
ABSTRACT
READ MORE: Uncovering New HIV Sanctuaries: Potential Roadblocks to a Cure
APRIL 2007
Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
J Virol. 2007 Apr;81(8):4033-43.
ABSTRACT
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines
Law M, Cardoso RM, Wilson IA, Burton DR.
Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
J Virol. 2007 Apr;81(8):4272-85.
ABSTRACT
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines
Huthoff H, Malim MH.
Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidation.
J Virol. 2007 Apr;81(8):3807-15.
ABSTRACT
Pohlmann S, Munch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Matz-Rensing K, Schneider T, Doms RW, Kirchhoff F.
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Virology. 2007 Apr 10;360(2):275-85.
ABSTRACT
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines
Zhang L, Kovalev GI, Su L.
HIV-1 infection and pathogenesis in a novel humanized mouse model.
Blood. 2007 Apr 1;109(7):2978-81.
ABSTRACT
MARCH 2007
Tempalski B, Flom PL, Friedman SR, Des Jarlais DC, Friedman JJ, McKnight C, Friedman R.
Social and political factors predicting the presence of syringe exchange programs in 96 US metropolitan areas.
Am J Public Health. 2007 Mar;97(3):437-47.
ABSTRACT
Fang L, Landau NR.
Analysis of Vif-induced APOBEC3G degradation using an alpha-complementation assay.
Virology. 2007 Mar 1;359(1):162-9.
ABSTRACT
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy
Schrofelbauer B, Hakata Y, Landau NR.
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4130-5.
ABSTRACT
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy
FEBRUARY 2007
Alfadhli A, Huseby D, Kapit E, Colman D, Barklis E.
Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer.
J Virol. 2007 Feb;81(3):1472-8.
ABSTRACT
Bieniasz PD.
An intrinsic host defense against HIV-1 integration?
J Clin Invest. 2007 Feb;117(2):302-4
ABSTRACT
READ MORE: Integrase: A New Word in the Fight Against HIV
Cardoso RM, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson IA.
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
J Mol Biol. 2007 Feb 2;365(5):1533-44.
ABSTRACT
Baek K, Brown RS, Birrane G, Ladias JA.
Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J Mol Biol. 2007 Feb 16;366(2):563-73.
ABSTRACT
JANUARY 2007
Mehandru S, Poles MA, Tenner-Racz K, Manuelli V, Jean-Pierre P, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection.
J Virol. 2007 Jan;81(2):599-612.
ABSTRACT
J Zhou, NI Paton, R Ditangco, Y-MA Chen, A Kamarulzaman, N Kumarasamy, CKC Lee, PCK Li, TP Merati, P Phanuphak, S Pujari, A Vibhagool, F Zhang, J Chuah, KR Frost, DA Cooper, MG Law, on behalf of The TREAT Asia HIV Observational Database.
Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database.
HIV Medicine 8 (1), 8-16.
ABSTRACT
READ MORE: Treating HIV in Asia: Lessons from amfAR's TREAT Asia Program
BACK TO TOP
2006 PUBLICATIONS
DECEMBER 2006
Hakata Y, Landau NR.
Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. J Biol Chem. 2006 Dec 1;281(48):36624-31.
ABSTRACT
Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection.
PLoS Med. 2006 Dec 5;3(12):e484
ABSTRACT
READ MORE: The HAART—and Gut—Of Acute HIV Infection
Zhou J, Phanupak P, Kiertiburanakul S, Ditangco R, Kamarulzaman A, Pujary S; TREAT Asia HIV Observational Database.
Highly active antiretroviral treatment containing efavirenz or nevirapine and related toxicity in the TREAT Asia HIV Observational Database.
J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):501-3.
ABSTRACT
NOVEMBER 2006
Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS.
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol. 2006 Nov;13(11):1223-30.
ABSTRACT
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update
Kornbluth RS, Stone GW.
Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J Leukoc Biol. 2006 Nov;80(5):1084-102.
ABSTRACT
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update
Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants. Antimicrob Agents Chemother. 2006 Nov;50(11):3607-14.
ABSTRACT
OCTOBER 2006
Ances BM, Letendre S, Buzzell M, Marquie-Beck J, Lazaretto D, Marcotte TD, Grant I, Ellis RJ; HNRC Group.
Valproic acid does not affect markers of human immunodeficiency virus disease progression.
J Neurovirol. 2006 Oct;12(5):403-6.
ABSTRACT
Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC.
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition.
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15588-93.
ABSTRACT
READ MORE: Host Resistance Factors Preventing HIV Infection
Hatziioannou T, Princiotta M, Piatak M Jr, Yuan F, Zhang F, Lifson JD, Bieniasz PD.
Generation of simian-tropic HIV-1 by restriction factor evasion.
Science. 2006 Oct 6;314(5796):95.
ABSTRACT
READ MORE: Host Resistance Factors Preventing HIV Infection
Alimonti JB, Kimani J, Matu L, Wachihi C, Kaul R, Plummer FA, Fowke KR.
Characterization of CD8 T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya.
Immunol Cell Biol. 2006 Oct;84(5):482-5.
ABSTRACT
SEPTEMBER 2006
Holy A.
Antiviral acyclic nucleoside phosphonates structure activity studies.
Antiviral Res. 2006 Sep;71(2-3):248-53.
ABSTRACT
READ MORE: Designer Drugs For HIV
Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL.
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA.
Chem Biol. 2006 Sep;13(9):993-1000.
ABSTRACT
READ MORE: Designer Drugs For HIV
AUGUST 2006
Des Jarlais DC, Sloboda Z, Friedman SR, Tempalski B, McKnight C, Braine N.
Diffusion of the D.A.R.E and syringe exchange programs.
Am J Public Health. 2006 Aug;96(8):1354-8.
ABSTRACT
Valente ST, Goff SP.
Inhibition of HIV-1 gene expression by a fragment of hnRNP U.
Mol Cell. 2006 Aug;23(4):597-605.
ABSTRACT
JULY 2006
Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR.
Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
J Virol. 2006 Jul;80(13):6324-32
ABSTRACT
READ MORE: HIV and the Brain
Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Jul 20;351(1):226-36.
ABSTRACT
JUNE 2006
Barron MA, Blyveis N, Pan SC, Wilson CC.
Human Dendritic Cell Interactions with Whole Recombinant Yeast: Implications for HIV-1 Vaccine Development.
J Clin Immunol. 2006 May 13.
ABSTRACT
Bhattacharya J, Repik A, Clapham PR.
Gag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes.
J Virol. 2006 Jun;80(11):5292-300.
ABSTRACT
READ MORE: Identifying Vulnerabilities in HIV as New Drug Targets
Schrofelbauer B, Senger T, Manning G, Landau NR.
Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3G.
J Virol. 2006 Jun;80(12):5984-91.
ABSTRACT
MAY 2006
Anand AR, Ganju RK.
HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.
J Biol Chem. 2006 May 5;281(18):12289-99.
ABSTRACT
READ MORE: Exploring How HIV Kills Cells of the Immune System
APRIL 2006
Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Apr 19. [Epub ahead of print]
ABSTRACT
READ MORE: The Challenge of Drug-Resistant HIV
Coskun AK, van Maanen M, Nguyen V, Sutton RE.
Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.
J Virol. 2006 Apr;80(7):3406-15.
ABSTRACT
READ MORE: Fighting HIV with Genetics
MARCH 2006
Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH.
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.
J Virol. 2006 Mar;80(5):2578-81.
ABSTRACT
Chiu YL, Greene WC.
APOBEC3 Cytidine Deaminases: Distinct Antiviral Actions along the Retroviral Life Cycle.
J Biol Chem. 2006 Mar 31;281(13):8309-12.
ABSTRACT
Chen H, Lilley CE, Yu Q, Lee DV, Chou J, Narvaiza I, Landau NR, Weitzman MD.
APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.
Curr Biol. 2006 Mar 7;16(5):480-5.
ABSTRACT
Saphire AC, Gallay PA, Bark SJ.
Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins.
J Proteome Res. 2006 Mar;5(3):530-8.
ABSTRACT
FEBRUARY 2006
Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE.
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
J Virol. 2006 Feb;80(4):1680-7.
ABSTRACT
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine
Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS.
Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines.
J Virol. 2006 Feb;80(4):1762-72.
ABSTRACT
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine
JANUARY 2006
Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J.
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.
Nature. 2006 Jan 5;439(7072):89-94.
ABSTRACT
READ MORE: A Novel Strategy Against Sexually Transmitted Infections
2005 PUBLICATIONS
DECEMBER 2005
Alfadhli A, Dhenub TC, Still A, Barklis E.
Analysis of human immunodeficiency virus type 1 Gag dimerization-induced assembly.
J Virol. 2005 Dec;79(23):14498-506.
ABSTRACT
Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
EMBO J. 2005 Dec 21;24(24):4291-303.
ABSTRACT
Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.
Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.
Nucleic Acids Res. 2005 Dec 23;33(22):7000-10.
ABSTRACT
Perez-Caballero D, Hatziioannou T, Zhang F, Cowan S, Bieniasz PD.
Restriction of Human Immunodeficiency Virus Type 1 by TRIM-CypA Occurs with Rapid Kinetics and Independently of Cytoplasmic Bodies, Ubiquitin, and Proteasome Activity
J Virol. 2005 Dec;79(24):15567-72.
ABSTRACT
Hsu M, Ho S, Balfe P, Gettie A, Harouse J, Blanchard J, Cheng-Mayer C.
A CCR5-Tropic Simian-HIV Molecular Clone Capable of Inducing AIDS in Rhesus Macaques.
JAIDS. 2005 Dec 1; 40(4):383-387.
ABSTRACT
Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC.
"Wide-Open" 1.3 A Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target.
Structure (Camb). 2005 Dec;13(12):1887-1895.
ABSTRACT
Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK.
Transgenic plant production of Cyanovirin-N, an HIV microbicide.
FASEB J. 2005 Dec 14;
ABSTRACT
READ MORE: Using Tobacco to Prevent HIV
Voronin Y, Overbaugh J, Emerman M.
Simian immunodeficiency virus variants that differ in pathogenicity differ in fitness under rapid cell turnover conditions.
J Virol. 2005 Dec;79(24):15091-8.
ABSTRACT
NOVEMBER 2005
Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE Jr, Fink A, Gilmore GT, Staley C, Ward A, Ali O, Binderow S, Cohen S, Grohskopf LA, Paxton L, Hart CE, Dezzutti CS.
A Human Colorectal Explant Culture to Evaluate Topical Microbicides for the Prevention of HIV Infection.
J Infect Dis. 2005 Nov 1;192(9):1545-56.
ABSTRACT
OCTOBER 2005
Berthoux L, Sebastian S, Sokolskaja E, Luban J.
Cyclophilin A is required for TRIM5alpha-mediated resistance to HIV-1 in Old World monkey cells.
PNAS. 2005 Oct 11; 102(41):14849-14853.
ABSTRACT
Selvarajah S, Puffer B, Pantophlet R, Law M, Doms RW, Burton DR.
Comparing antigenicity and immunogenicity of engineered gp120.
J Virol. 2005 Oct;79(19):12148-63.
ABSTRACT
Arien KK, Troyer RM, Gali Y, Colebunders RL, Arts EJ, Vanham G.
Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time.
AIDS. 2005 Oct 14;19(15):1555-1564.
ABSTRACT
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time
SEPTEMBER 2005
Barboric M, Zhang F, Besenicar M, Plemenitas A, Peterlin BM.
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation.
J Virol. 2005 Sep;79(17):11135-41.
ABSTRACT
Reeves JD, Piefer AJ.
Emerging drug targets for antiretroviral therapy.
Drugs. 2005;65(13):1747-66.
ABSTRACT
AUGUST 2005
Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, Francois-Bongarcon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P.
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.
Blood. 2005 Aug 1;106(3):818-26. Epub 2005 Apr 14.
ABSTRACT
Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. Epub 2005 Aug 4
ABSTRACT
JULY 2005
Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Jul 1;280(26):24968-77.
ABSTRACT
Balasubramanian A, Koziel M, Groopman J, Ganju RK.
Molecular mechanism of hepatic injury in coinfection with hepatitis C virus and HIV.
Clin. Infect. Dis. 2005 Jul 1;41(Suppl 1):S32-37.
ABSTRACT
Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD.
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.
J Virol. 2005 Jul;79(14):8969-78.
ABSTRACT
Troyer RM, Collins KR, Abraha A, Fraundorf E, Moore DM, Krizan RW, Toossi Z, Colebunders RL, Jensen MA, Mullins JI, Vanham G, Arts EJ.
Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression.
J Virol. 2005 Jul;79(14):9006-18.
ABSTRACT
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time
JUNE 2005
Berthoux L, Sebastian S, Sayah DM, Luban J.
Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Virol. 2005 Jun;79(12):7883-8.
ABSTRACT
Senkovich O, Speed H, Grigorian A, Bradley K, Ramarao CS, Lane B, Zhu G, Chattopadhyay D.
Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum.
Biochim Biophys Acta. 2005 Jun 10;
ABSTRACT
Marozsan AJ, Moore DM, Lobritz MA, Fraundorf E, Abraha A, Reeves JD, Arts EJ.
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry.
J Virol. 2005 Jun;79(11):7121-34.
ABSTRACT
MAY 2005
Huseby D, Barklis RL, Alfadhli A, Barklis E.
Assembly of human immunodeficiency virus precursor gag proteins.
J Biol Chem. 2005 May 6;280(18):17664-70.
ABSTRACT
Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC.
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.
Nature. 2005 May 5;435(7038):108-14. Epub 2005 Apr 13.
ABSTRACT
Ylisastigui L, Kaur R, Johnson H, Volker J, He G, Hansen U, Margolis D.
Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter.
J Virol. 2005 May;79(10):5952-62.
ABSTRACT
Smith AJ, Meyer PR, Asthana D, Ashman MR, Scott WA.
Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.
Antimicrob Agents Chemother. 2005 May;49(5):1761-9.
ABSTRACT
APRIL 2005
Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Apr 25;
ABSTRACT
Dolakova P, Holy A, Zidek Z, Masojidkova M, Kmonickova E.
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorg Med Chem. 2005 Apr 1;13(7):2349-54.
ABSTRACT
Ibarrondo FJ, Anton PA, Fuerst M, Ng HL, Wong JT, Matud J, Elliott J, Shih R, Hausner MA, Price C, Hultin LE, Hultin PM, Jamieson BD, Yang OO.
Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infection.
J Virol. 2005 Apr;79(7):4289-97.
ABSTRACT
Reeves JD, Lee FH, Miamidian JL, Jabara CB, Juntilla MM, Doms RW.
Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.
J Virol. 2005 Apr;79(8):4991-9.
ABSTRACT
MARCH 2005
Chung E, Amrute SB, Abel K, Gupta G, Wang Y, Miller CJ, Fitzgerald-Bocarsly P.
Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque.
Clin Diagn Lab Immunol. 2005 Mar;12(3):426-35.
ABSTRACT
Navarro F, Bollman B, Chen H, Konig R, Yu Q, Chiles K, Landau NR.
Complementary function of the two catalytic domains of APOBEC3G.
Virology. 2005 Mar 15;333(2):374-86.
ABSTRACT
FEBRUARY 2005
Barboric M, Peterlin B.M.
A New Paradigm in Eukaryotic Biology: HIV Tat and the Control of Transcriptional Elongation.
PloS Biol. 3(2): e76
ABSTRACT
Cardoso RM, Zwick MB, Stanfield RL, Kunert R, Binley JM, Katinger H, Burton DR, Wilson IA.
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41.
Immunity. 2005 Feb;22(2):163-73.
ABSTRACT
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research
Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Structure of an unliganded simian immunodeficiency virus gp120 core.
Nature. 2005 Feb 24;433(7028):834-41.
ABSTRACT
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research
Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein.
Structure (Camb). 2005 Feb;13(2):197-211.
ABSTRACT
Lenz O, Dittmar MT, Wagner A, Ferko B, Vorauer-Uhl K, Stiegler G, Weissenhorn W.
Trimeric Membrane-anchored gp41 Inhibits HIV Membrane Fusion.
J Biol Chem. 2005 Feb 11;280(6):4095-4101. Epub 2004 Dec 1.
ABSTRACT
Zhou J, Kumarasamy N, Ditangco R, Kamarulzaman A, Lee CK, Li PC, Paton NI, Phanuphak P, Pujari S, Vibhagool A, Wong WW, Zhang F, Chuah J, Frost KR, Cooper DA, Law MG; TREAT Asia HIV Observational Database.
The TREAT Asia HIV Observational Database: baseline and retrospective data.
J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):174-9.
ABSTRACT
JANUARY 2005
Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.
ABSTRACT
Alimonti JB, Koesters SA, Kimani J, Matu L, Wachihi C, Plummer FA, Fowke KR.
CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women.
J Infect Dis. 2005 Jan 1;191(1):20-4. Epub 2004 Dec 01.
ABSTRACT
Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD.
Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.
J Virol. 2005 Jan;79(1):176-83.
ABSTRACT
Hill M, Tachedjian G, Mak J.
The packaging and maturation of the HIV-1 Pol proteins.
Curr HIV Res. 2005 Jan;3(1):73-85.
ABSTRACT
*****Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.
ABSTRACT
2004 PUBLICATIONS
DECEMBER 2004
Albright AV, Gonzalez-Scarano F.
Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression.
J Neuroimmunol. 2004 Dec;157(1-2):27-38.
ABSTRACT
Ambrose Z, Boltz V, Palmer S, Coffin JM, Hughes SH, Kewalramani VN.
In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.
J Virol. 2004 Dec;78(24):13553-61.
ABSTRACT
Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D.
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.
Genes Dev. 2004 Dec 1;18(23):2861-6.
ABSTRACT
De Berardinis P, Haigwood NL.
New recombinant vaccines based on the use of prokaryotic antigen-display systems.
Expert Rev Vaccines. 2004 Dec;3(6):673-9.
ABSTRACT
Yu Q, Chen D, Konig R, Mariani R, Unutmaz D, Landau NR.
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
J Biol Chem. 2004 Dec 17;279(51):53379-86. Epub 2004 Oct 04.
ABSTRACT
Francois-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J.
Cross-Clade CD8 T-Cell Responses to HIVIIIB and Chinese B' and C/B' Viruses in North American and Chinese HIV-Seropositive Donors.
J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1435-1444.
ABSTRACT
NOVEMBER 2004
Zerhouni B, Nelson JA, Saha K.
CXCR4-dependent infection of CD8+, but not CD4+, lymphocytes by a primary human immunodeficiency virus type 1 isolate.
J Virol. 2004 Nov;78(22):12288-96.
ABSTRACT
OCTOBER 2004
Khan MZ, Brandimarti R, Patel JP, Huynh N, Wang J, Huang Z, Fatatis A, Meucci O.
Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.
AIDS Res Hum Retroviruses. 2004 Oct;20(10):1063-71.
ABSTRACT
Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.
J Biol Chem. 2004 Oct 29;279(44):45389-98. Epub 2004 Aug 11.
ABSTRACT
Pantophlet R, Wilson IA, Burton DR.
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12.
Protein Eng Des Sel. 2004 Oct;17(10):749-58.
ABSTRACT
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