amfAR, The Foundation for AIDS Research

Publications from amfAR Grantees and Fellows

Click here for publications prior to 2013.

Publications of amfAR Grantees and Fellows


Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff. 

February 2020

A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
Michael J Peluso, Lynda Dee , Danielle Campbell , Jeff Taylor , Rebecca Hoh, Rachel L Rutishauser, John Sauceda, Steven G Deeks , Karine Dubé
JVE. 2020. 6:34-37


Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy.
Peluso MJ, Bacchetti P, Ritter KD, Beg SA, Lai J, Martin JN, Hunt PW, Henrich TJ, Siliciano JD, Siliciano RF, Laird GM, Deeks SG.
JCI Insight. 2020 Feb 11. pii: 132997. doi: 10.1172/jci.insight.132997.


Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy.
Schwarzer R, Gramatica A, Greene WC.
Viruses. 2020 Feb 8;12(2). pii: E188. doi: 10.3390/v12020188.


A systems approach to infectious disease.
Eckhardt M, Hultquist JF, Kaake RM, Hüttenhain R, Krogan NJ.
Nat Rev Genet. 2020 Feb 14. doi: 10.1038/s41576-020-0212-5.


Kick and kill for HIV latency.
Lewin SR, Rasmussen TA.
Lancet. 2020 Feb 18. pii: S0140-6736(20)30264-6. doi: 10.1016/S0140-6736(20)30264-6.


January 2020

Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M.
AIDS. 2020 Jan 17. doi: 10.1097/QAD.0000000000002476.


High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.
Horsburgh BA, Lee E, Hiener B, Eden JS, Schlub TE, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek DC, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
AIDS. 2020 Jan 6. doi: 10.1097/QAD.0000000000002465. 


Combination Immune Checkpoint Blockade to Reverse HIV Latency.
Van der Sluis RM, Kumar NA, Pascoe RD, Zerbato JM, Evans VA, Dantanarayana AI, Anderson JL, Sékaly RP, Fromentin R, Chomont N, Cameron PU, Lewin SR.
J Immunol. 2020 Jan 27. pii: ji1901191. doi: 10.4049/jimmunol.1901191. 


HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4+ T cells.
Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD.
J Virol. 2020 Jan 15. pii: JVI.01999-19. doi: 10.1128/JVI.01999-19. 


Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.
Yang YR, McCoy LE, van Gils MJ, Andrabi R, Turner HL, Yuan M, Cottrell CA, Ozorowski G, Voss J, Pauthner M, Polveroni TM, Messmer T, Wilson IA, Sanders RW, Burton DR, Ward AB.
J Virol. 2020 Jan 15. pii: JVI.01861-19. doi: 10.1128/JVI.01861-19. 


December 2019

Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.
Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR.
Mucosal Immunol. 2019 Dec 4. doi: 10.1038/s41385-019-0238-1.


Why and where an HIV cure is needed and how it might be achieved.
Ndung'u T, McCune JM, Deeks SG.
Nature. 2019 Dec;576(7787):397-405.


Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells.
Nguyen S, Deleage C, Darko S, Ransier A, Truong DP, Agarwal D, Japp AS, Wu VH, Kuri-Cervantes L, Abdel-Mohsen M, Del Rio Estrada PM, Ablanedo-Terrazas Y, Gostick E, Hoxie JA, Zhang NR, Naji A, Reyes-Terán G, Estes JD, Price DA, Douek DC, Deeks SG, Buggert M, Betts MR.
Sci Transl Med. 2019 Dec 18;11(523).


Quantification of viral RNA and DNA positive cells in tissues from simiam immunodeficiency virus/simian human immunodeficiency virus infected controller and progressor rhesus macaques.
Pahar B, Kuebler D, Rasmussen T, Wang X, Srivastav SK, Das A, Veazey RS.
Front Micro 2019 Dec 20. doi: 10.3389/fmicb.2019.02933.


November 2019

The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites.
Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
J Virol. 2019 Nov 13. pii: JVI.01270-19. doi: 10.1128/JVI.01270-19.


Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy.
Pardons M, Fromentin R, Pagliuzza A, Routy JP, Chomont N.
Cell Rep. 2019 Nov 26;29(9):2783-2795.


Circulating CD30+ CD4+ T Cells Increase Prior to HIV Rebound Following Analytical Antiretroviral Treatment Interruption.
Prator CA, Thanh C, Kumar S, Pan T, Peluso MJ, Bosch R, Jones N, Milush JM, Bakkour S, Stone M, Busch MP, Deeks SG, Hunt PW, Henrich TJ.
J Infect Dis. 2019 Nov 2. pii: jiz572. doi: 10.1093/infdis/jiz572.


October 2019

Infrequent HIV infection of circulating monocytes during antiretroviral therapy.
Massanella M, Bakeman W, Sithinamsuwan P, Fletcher JLK, Chomchey N, Tipsuk S, Chalermchai T, Routy JP, Ananworanich J, Valcour VG, Chomont N; SEARCH 011 Study Group.
J Virol. 2019 Oct 9. pii: JVI.01174-19.

Pharmacological modulation of the Wnt/β-catenin pathway inhibits proliferation and promotes differentiation of long-lived memory CD4+ T-cells in ART-suppressed SIV-infected macaques.
Mavigner M, Zanoni M, Tharp GK, Habib J, Mattingly CR, Lichterfeld M, Nega MT, Vanderford TH, Bosinger SE, Chahroudi A.
J Virol. 2019 Oct 16. pii: JVI.01094-19.

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.
Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC.
Cell. 2019 Oct 31;179(4):880-894.

Community and provider Community and provider perspectives on Treatment Interruptions in the landscape of HIV cure focused studies.
Lau J, Smith MZ, Allan B, Martinez C, Power J, Lewin SR, McMahon JH.
AIDS Res Hum Retroviruses. 2019 Oct 14. doi: 10.1089/AID.2019.0118.

September 2019

Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.
Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL.
J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):211-219.

Seeing Is Believing: Nuclear Imaging of HIV Persistence.
Henrich TJ, Hsue PY, VanBrocklin H.
Front Immunol. 2019 Sep 12;10:2077. doi: 10.3389/fimmu.2019.02077

A new family of small-molecule CD4-mimetic compounds contact the highly conserved aspartic acid 368 of HIV-1 gp120 and mediates ADCC.
Ding S, Grenier MC, Tolbert WD, Vézina D, Sherburn R, Richard J, Prévost J, Chapleau JP, Gendron-Lepage G, Medjahed H, Abrams C, Sodroski J, Pazgier M, Smith AB 3rd, Finzi A.
J Virol. 2019 Sep 25. pii: JVI.01325-19. doi: 10.1128/JVI.01325-19.

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, Behrens AJ, Catalano M, Del Moral-Sánchez I, Ketas TJ, LaBranche C, van Gils MJ, Sliepen K, Stewart LJ, Crispin M, Montefiori DC, Baker D, Moore JP, Klasse PJ, Ward AB, King NP, Sanders RW.
Nat Commun. 2019 Sep 19;10(1):4272.

August 2019

A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.
Ehrenberg PK, Shangguan S, Issac B, Alter G, Geretz A, Izumi T, Bryant C, Eller MA, Wegmann F, Apps R, Creegan M, Bolton DL, Sekaly RP, Robb ML, Gramzinski RA, Pau MG, Schuitemaker H, Barouch DH, Michael NL, Thomas R.
Sci Transl Med. 2019 Aug 28;11(507).

Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer.
Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J.
J Virol. 2019 Aug 7. pii: JVI.01197-19. doi: 10.1128/JVI.01197-19.


July 2019

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J.
PLoS Pathog. 2019 Jul 1;15(7):e1007925.


June 2019

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.
Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J.
MBio. 2019 Jun 18;10(3). pii: e01113-19.

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ.
Cell Host Microbe. 2019 Jun 24. pii: S1931-3128(19)30253-7.

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Yuan M, Cottrell CA, Ozorowski G, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB, Wilson IA.
Cell Host Microbe. 2019 Jun 12;25(6):873-883.


May 2019

CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ.
Pathog Immun. 2019 May 3;4(1):147-160.


A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries.
Kapoor N, Audsley J, Rupali P, Sasadeusz J, Paul TV, Thomas N, Lewin SR.
AIDS. 2019 Jun 1;33(7):1105-1115.


April 2019

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members.
Gonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, Porterfield JZ, Lampkin TD, Marconi VC, Rimland D, Walker BD, Deeks S, Sutton RE.
Elife. 2019 Apr 9;8. pii: e44360.

An asymmetric opening of HIV-1 envelope mediates antibody-dependent cellular cytotoxicity.
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB.
Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.
Rosenbloom DIS, Bacchetti P, Stone M, Deng X, Bosch RJ, Richman DD, Siliciano JD, Mellors JW, Deeks SG, Ptak RG, Hoh R, Keating SM, Dimapasoc M, Massanella M, Lai J, Sobolewski MD, Kulpa DA, Busch MP; Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group.
PLoS Comput Biol. 2019 Apr 12;15(4):e1006849.


March 2019

Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.
Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD.
Lancet HIV. 2019 Mar 15. pii: S2352-3018(19)30052-9.

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.
Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Picado J, Nijhuis M, Wensing AMJ, Lee H, Grant P, Nastouli E, Lambert J, Pace M, Salasc F, Monit C, Innes AJ, Muir L, Waters L, Frater J, Lever AML, Edwards SG, Gabriel IH, Olavarria E.
Nature. 2019 Mar 5. doi: 10.1038/s41586-019-1027-4.

Clinical trials of antiretroviral treatment interruption in HIV-infected individuals.
Lau JSY, Smith MZ, Lewin SR, McMahon JH.
AIDS. 2019 Apr 1;33(5):773-791.

Modulation of the CCR5 receptor/ligand axis by seminal plasma and the utility of in vitro versus in vivo models.
Juno JA, Wragg KM, Kristensen AB, Lee WS, Selva KJ, van der Sluis RM, Kelleher AD, Bavinton BR, Grulich AE, Lewin SR, Kent SJ, Parsons MS.
J Virol. 2019 Mar 13. pii: JVI.00242-19. doi: 10.1128/JVI.00242-19.

Antibody-induced internalization of HIV-1 Env proteins limits the surface expression of the closed conformation of Env.
Anand SP, Grover JR, Tolbert WD, Prévost J, Richard J, Ding S, Baril S, Medjahed H, Evans DT, Pazgier M, Mothes W, Finzi A.
J Virol. 2019 Mar 20. pii: JVI.00293-19. doi: 10.1128/JVI.00293-19.

CD4- and time-dependent susceptibility of HIV-1-infected cells to ADCC.
Lee WS, Prévost J, Richard J, van der Sluis RM, Lewin SR, Pazgier M, Finzi A, Parsons MS, Kent SJ.
J Virol. 2019 Mar 6. pii: JVI.01901-18. doi: 10.1128/JVI.01901-18.

Deoxyuridine in DNA has an inhibitory and promutagenic effect on RNA transcription by diverse RNA polymerases.
Cui J, Gizzi A, Stivers JT.
Nucleic Acids Res. 2019 Mar 20. pii: gkz183. doi: 10.1093/nar/gkz183.

Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.
Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA.
AIDS. 2019 Mar 1;33(3):425-431. doi: 10.1097/QAD.0000000000002083.


February 2019

Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis.
Colomb F, Giron LB, Trbojevic-Akmacic I, Lauc G, Abdel-Mohsen M.
Curr HIV/AIDS Rep. 2019 Feb 1. doi: 10.1007/s11904-019-00433-w.


Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N.
PLoS Pathog. 2019 Feb 27;15(2):e1007619.


PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ, Lewin SR, Routy JP, Sékaly RP, Chomont N.
Nat Commun. 2019 Feb 18;10(1):814.


Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.
Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM.
Clin Pharmacol Ther. 2019 Mar;105(3):692-702.


Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells.
Al-Shehabi H, Fiebig U, Kutzner J, Denner J, Schaller T, Bannert N, Hofmann H.
J Gen Virol. 2019 Feb 15. doi: 10.1099/jgv.0.001232.


Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells.
Verheyen J, Thielen A, Lübke N, Dirks M, Widera M, Dittmer U, Kordelas L, Däumer M, de Jong DCM, Wensing AMJ, Kaiser R, Nijhuis M, Esser S.
Clin Infect Dis. 2019 Feb 1;68(4):684-687.


Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors.
Van Hecke C, Trypsteen W, Malatinkova E, De Spiegelaere W, Vervisch K, Rutsaert S, Kinloch-de Loes S, Sips M, Vandekerckhove L.
EBioMedicine. 2019 Feb 12. pii: S2352-3964(19)30078-7.


Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.
Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA.
AIDS. 2019 Mar 1;33(3):425-431.


January 2019

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.
Li Z, Wu J, Chavez L, Hoh R, Deeks SG, Pillai SK, Zhou Q.
PLoS Pathog. 2019 Jan 15;15(1):e1007498.


December 2018

Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma.
Wang CC, Thanh C, Gibson EA, Ball-Burack M, Hogan LE, Descours B, Jones N, Carvidi AB, Munter S, Bakkour S, Busch MP, Milush JM, Deeks SG, Henrich TJ.
Blood Adv. 2018 Dec 11;2(23):3479-3482. doi: 10.1182/bloodadvances.2018024364.

HIV latency can be established in proliferating and nonproliferating resting CD4+ T cells in vitro: implications for latency reversal.
Moso MA, Anderson JL, Adikari S, Gray LR, Khoury G, Chang JJ, Jacobson JC, Ellett AM, Cheng WJ, Saleh S, Zaunders JJ, Purcell DFJ, Cameron PU, Churchill MJ, Lewin SR, Lu HK.
AIDS. 2019 Feb 1;33(2):199-209.

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.
Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A.
Cell Metab. 2018 Dec 19. pii: S1550-4131(18)30734-4.

CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions.
Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A, Krogan NJ.
Nat Protoc. 2019 Jan;14(1):1-27.

Stimulant Use and Viral Suppression in the Era of Universal Antiretroviral Therapy.
Carrico AW, Hunt PW, Neilands TB, Dilworth SE, Martin JN, Deeks SG, Riley ED.
J Acquir Immune Defic Syndr. 2019 Jan 1;80(1):89-93.


November 2018

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA.
PLoS Pathog. 2018 Nov 15;14(11):e1007357.


HIV control: Is getting there the same as staying there?
Goulder P, Deeks SG.
PLoS Pathog. 2018 Nov 1;14(11):e1007222.


Two families of Env antibodies efficiently engage Fc-gamma receptors and eliminate HIV-1-infected cells.
Anand SP, Prévost J, Baril S, Richard J, Medjahed H, Chapleau JP, Tolbert WD, Kirk S, Smith AB 3rd, Wines BD, Kent SJ, Hogarth PM, Parsons MS, Pazgier M, Finzi A.
J Virol. 2018 Nov 14. pii: JVI.01823-18.


Functional cure of HIV: the scale of the challenge.
Davenport MP, Khoury DS, Cromer D, Lewin SR, Kelleher AD, Kent SJ.
Nat Rev Immunol. 2018 Nov 8. doi: 10.1038/s41577-018-0085-4.


HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth.
van Schooten J, van Gils MJ.
Retrovirology. 2018 Nov 26;15(1):74.


Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant.
Salgado M, Kwon M, Gálvez C, Badiola J, Nijhuis M, Bandera A, Balsalobre P, Miralles P, Buño I, Martinez-Laperche C, Vilaplana C, Jurado M, Clotet B, Wensing A, Martinez-Picado J, Diez-Martin JL; IciStem Consortium.
Ann Intern Med. 2018 Nov 20;169(10):674-683.


A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells.
Yu D, Ye L.
Trends Immunol. 2018 Dec;39(12):965-979.


October 2018

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.
Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH.
Nature. 2018 Oct 3. doi: 10.1038/s41586-018-0600-6.


Functional mapping of regions involved in the negative imprinting of virion particles infectivity and in target cell protection by the Interferon-Induced Transmembrane Protein 3 (IFITM3) against HIV-1.
Appourchaux R, Delpeuch M, Zhong L, Burlaud-Gaillard J, Tartour K, Savidis G, Brass A, Etienne L, Roingeard P, Cimarelli A.
J Virol. 2018 Oct 24. pii: JVI.01716-18.


Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation.
Scully EP, Gandhi M, Johnston R, Hoh R, Lockhart A, Dobrowolski C, Pagliuzza A, Milush JM, Baker CA, Girling V, Ellefson A, Gorelick R, Lifson J, Altfeld M, Alter G, Cedars M, Solomon A, Lewin SR, Karn J, Chomont N, Bacchetti P, Deeks SG.
J Infect Dis. 2018 Oct 29. doi: 10.1093/infdis/jiy617.


Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV.
Massanella M, Karris MY, Pérez-Santiago J, Yek C, Vitomirov A, Mehta SR.
J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):399-406.


September 2018

HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.
Sung JA, Patel S, Clohosey ML, Roesch L, Tripic T, Kuruc JD, Archin N, Hanley PJ, Cruz CR, Goonetilleke N, Eron JJ, Rooney CM, Gay CL, Bollard CM, Margolis DM.
Mol Ther. 2018 Sep 4. pii: S1525-0016(18)30400-3. doi: 10.1016/j.ymthe.2018.08.015.


No recovery of replication-competent HIV-1 from human liver macrophages.
Kandathil AJ, Sugawara S, Goyal A, Durand CM, Quinn J, Sachithanandham J, Cameron AM, Bailey JR, Perelson AS, Balagopal A.
J Clin Invest. 2018 Sep 10. pii: 121678. doi: 10.1172/JCI121678.


August 2018

HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.
Agosto LM, Herring MB, Mothes W, Henderson AJ.
Cell Rep. 2018 Aug 21;24(8):2088-2100.  


Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial.
Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM.
Clin Pharmacol Ther. 2018 Aug 23. doi: 10.1002/cpt.1220.

The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies.
Namazi G, Fajnzylber JM, Aga E, Bosch R, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith D, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks S, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ.
J Infect Dis. 2018 Aug 6. doi: 10.1093/infdis/jiy479.

July 2018

Maximising the global health impact of future HIV cure-related interventions through advance planning.
Brown R, Deeks SG, Eyal N.
J Virus Erad. 2018 Jul 1;4(3):182-185.


Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection.
Scully EP, Rutishauser RL, Simoneau CR, Delagrèverie H, Euler Z, Thanh C, Li JZ, Hartig H, Bakkour S, Busch M, Alter G, Marty FM, Wang CC, Deeks SG, Lorch J, Henrich TJ.
Ann Oncol. 2018 Jul 18. doi: 10.1093.


Ethical issues in HIV remission trials.
Eyal N, Holtzman LG, Deeks SG.
Curr Opin HIV AIDS. 2018 Sep;13(5):422-427.


Variation in cell associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator BMAL-1.
Chang CC, Naranbhai V, Stern J, Roche M, Dantanarayana A, Ke R, Tennakoon S, Solomon A, Hoh R, Hartogensis W, Hecht FM, Sikaris K, Price DJ, Elliott JH, Deeks SG, Churchill M, Cameron PU, Hengartner N, Perelson AS, Lewin SR.
AIDS. 2018 Jul 12. doi: 10.1097/QAD.0000000000001937.


Structural Insights from HIV-Antibody Co-Evolution and Related Immunization Studies.
Zhou JO, Ton T, Morriss JW, Nguyen D, Fera D.
AIDS Res Hum Retroviruses. 2018 Jul 7. doi: 10.1089/AID.2018.0097


SOSIP changes affect human immunodeficiency virus (HIV-1) envelope glycoprotein conformation and CD4 engagement.
Alsahafi N, Anand SP, Castillo-Menendez L, Verly MM, Medjahed H, Prévost J, Herschhorn A, Richard J, Schön A, Melillo B, Freire E, Smith AB 3rd, Sodroski J, Finzi A.
J Virol. 2018 Jul 18. pii: JVI.01080-18.


The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells.
Alvarez-Carbonell D, Ye F, Ramanath N, Dobrowolski C, Karn J.
J Neuroimmune Pharmacol. 2018 Jul 10. doi: 10.1007/s11481-018-9798-1.


Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
Biswajit Das, Curtis Dobrowolski, Benjamin Luttge, Saba Valadkhan, Nicolas ChomontRowena Johnston, Peter Bacchetti, Rebecca Hoh, Monica Gandhi, Steven G. DeeksEileen Scully, and Jonathan Karn
PNAS July 30, 2018. 201803468; published ahead of print July 30, 2018. 


Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4+ T Cells.
Kumar NA, van der Sluis RM, Mota T, Pascoe R, Evans VA, Lewin SR, Cameron PU.
J Immunol. 2018 Jul 20. pii: ji1701233.


Barriers for a HIV cure: the latent reservoir.
Castro-Gonzalez S, Colomer-Lluch M, Serra-Moreno R.
AIDS Res Hum Retroviruses. 2018 Jul 28. doi: 10.1089/AID.2018.0118.


Protective efficacy of broadly neutralizing antibody PGDM1400 against HIV-1 challenge in humanized mice.
van der Velden Y, Villaudy J, Siteur-van Rijnstra E, van der Linden C, Franklin E, Weijer K, Schermer E, Vink M, Berkhout B, Sanders RW, Van Gils M.
AIDS Res Hum Retroviruses. 2018 Jul 13. doi: 10.1089/AID.2018.0114.


Rapid rebound of a preexisting CXCR4-tropic HIV variant after allogeneic transplantation with CCR5 delta32 homozygous stem cells.
Verheyen J, Thielen A, Lübke N, Dirks M, Widera M, Dittmer U, Kordales L, Däumer M, Jong TCM, Wensing AMJ, Kaiser R, Nijhuis M, Esser S.
Clin Infect Dis. 2018 Jul 18. doi: 10.1093/cid/ciy565.


Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome.
Tso FY, Kang G, Kwon EH, Julius P, Li Q, West JT, Wood C.
PLoS One. 2018 Jul 24;13(7):e0201325.


June 2018

CD4+ T cell subsets and pathways to HIV latency.
Agosto LM, Henderson AJ.
AIDS Res Hum Retroviruses. 2018 Jun 5. doi: 10.1089/AID.2018.0105.

A step forward for HIV vaccines.
Barouch DH.
Lancet HIV. 2018 Jun 8. pii: S2352-3018(18)30095-X.

Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.
Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.
Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526.

HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F.
Nat Microbiol. 2018 Jun 11. doi: 10.1038/s41564-018-0179-6.

NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation.
Hogan LE, Körner C, Hobbs K, Simoneau CR, Thanh C, Gibson EA, Palmer CD, Pandit A, Marty FM, Kuritzkes DR, Jost S, Ritz J, Henrich TJ.
Blood Adv. 2018 Jun 26;2(12):1412-1416.

Conformation-dependent interactions between HIV-1 envelope glycoproteins and broadly neutralizing antibodies.
Flemming J, Wiesen L, Herschhorn A.
AIDS Res Hum Retroviruses. 2018 Jun 15. doi: 10.1089/AID.2018.0102.

The Mathilde Krim effect as a way to overcome the Matilda effect.
Izquierdo-Useros N.
AIDS Res Hum Retroviruses. 2018 Jun 26. doi: 10.1089/AID.2018.0082.

Barriers and strategies to achieve a cure for HIV.
Pitman MC, Lau JSY, McMahon JH, Lewin SR.
Lancet HIV. 2018 Jun;5(6):e317-e328.

A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J.
Nat Commun. 2018 Jun 18;9(1):2363.

Influence of biological sex, age and HIV status in an in vitro primary cell model of HIV latency using a CXCR4 tropic virus.
Macedo AB, Resop RS, Martins LJ, Szaniawski MA, Sorensen ES, Spivak AM, Nixon DF, Jones RB, Planelles V, Bosque A.
AIDS Res Hum Retroviruses. 2018 Jun 21. doi: 10.1089/AID.2018.0098.

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection.
Stavrou S, Aguilera AN, Blouch K, Ross SR.
MBio. 2018 Jun 5;9(3). pii: e00923-18.



May 2018

HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M.
J Clin Invest. 2018 May 3. pii: 98943.


Human Herpes Virus 8 in HIV-1 infected individuals receiving cancer chemotherapy and stem cell transplantation.
Hogan LE, Hanhauser E, Hobbs KS, Palmer CD, Robles Y, Jost S, LaCasce AS, Abramson J, Hamdan A, Marty FM, Kuritzkes DR, Henrich TJ.
PLoS One. 2018 May 10;13(5):e0197298.


Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.
Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG.
J Histochem Cytochem. 2018 Jun;66(6):427-446.


Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
Mbonye U, Wang B, Gokulrangan G, Shi W, Yang S, Karn J.
J Biol Chem. 2018 May 9. pii: jbc.RA117.001347.


HIV latency reversing agents act through Tat post translational modifications.
Khoury G, Mota TM, Li S, Tumpach C, Lee MY, Jacobson J, Harty L, Anderson JL, Lewin SR, Purcell DFJ.
Retrovirology. 2018 May 11;15(1):36. doi: 10.1186/s12977-018-0421-6.


PD-1 contributes to the establishment and maintenance of HIV-1 latency.
Evans VA, Van Der Sluis RM, Solomon A, Dantanarayana A, McNeil C, Garsia R, Palmer S, Fromentin R, Chomont N, Sékaly RP, Cameron PU, Lewin SR.
AIDS. 2018 May 9. doi: 10.1097/QAD.0000000000001849.


April 2018

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM.
J Neurovirol. 2018 Apr;24(2):192-203.

Neutrophils mediate HIV-specific antibody-dependent phagocytosis and ADCC.
Worley MJ, Fei K, Lopez-Denman AJ, Kelleher AD, Kent SJ, Chung AW.
J Immunol Methods. 2018 Jun;457:41-52.

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.
Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.
PLoS Pathog. 2018 Apr 13;14(4):e1006973.

Incomplete downregulation of CD4 expression affects HIV-1 Env conformation and ADCC responses.
Prévost J, Richard J, Medjahed H, Alexander A, Jones J, Kappes JC, Ochsenbauer C, Finzi A.
J Virol. 2018 Apr 18. pii: JVI.00484-18.

Impact of HIV-1 Envelope Conformation on ADCC Responses.
Richard J, Prévost J, Alsahafi N, Ding S, Finzi A.
Trends Microbiol. 2018 Apr;26(4):253-265.


March 2018

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM.
PLoS Pathog. 2018 Mar 5;14(3):e1006806.

Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?
Burbelo PD, Price RW, Hagberg L, Hatano H, Spudich S, Deeks SG, Gisslén M.
J Infect Dis. 2018 Mar 13;217(7):1024-1032.

Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.
Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL.
J Immunol. 2018 Mar 1;200(5):1876-1888.

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.
Fera D, Lee MS, Wiehe K, Meyerhoff RR, Piai A, Bonsignori M, Aussedat B, Walkowicz WE, Ton T, Zhou JO, Danishefsky S, Haynes BF, Harrison SC.
Nat Commun. 2018 Mar 16;9(1):1111.

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses.
Richard J, Prévost J, Baxter AE, von Bredow B, Ding S, Medjahed H, Delgado GG, Brassard N, Stürzel CM, Kirchhoff F, Hahn BH, Parsons MS, Kaufmann DE, Evans DT, Finzi A.
MBio. 2018 Mar 20;9(2). pii: e00358-18.

Impact of HIV-1 Envelope Conformation on ADCC Responses.
Richard J, Prévost J, Alsahafi N, Ding S, Finzi A.
Trends Microbiol. 2018 Apr;26(4):253-265. doi: 10.1016/j.tim.2017.10.007. Epub 2017 Nov 20. Review.

HIV integration sites and implications for maintenance of the reservoir.
Symons J, Cameron PU, Lewin SR.
Curr Opin HIV AIDS. 2018 Mar;13(2):152-159.

Deaminase-Dead Mouse APOBEC3 is an In Vivo Retroviral Restriction Factor.
Stavrou S, Zhao W, Blouch K, Ross SR.
J Virol. 2018 Mar 28. pii: JVI.00168-18.


February 2018

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection.
Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, Valenzuela-Ponce H, Pfafferott K, Williams I, Pellegrino P, Borrow P, Mori M, Rockstroh J, Prado JG, Mothe B, Dalmau J, Martinez-Picado J, Tudor-Williams G, Frater J, Stryhn A, Buus S, Teran GR, Mallal S, John M, Buchbinder S, Kirk G, Martin J, Michael N, Fellay J, Deeks S, Walker B, Avila-Rios S, Cole D, Brander C, Carrington M, Goulder P.
J Virol. 2018 Jan 30;92(4).

HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors.
Bannert N, Hofmann H, Block A, Hohn O.
Front Microbiol. 2018 Feb 13;9:178.

Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals.
Prévost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A.
Virology. 2018 Feb;515:38-45

Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ.
PLoS Pathog. 2018 Feb 22;14(2):e1006856.

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.
Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RB.
J Clin Invest. 2018 Feb 1;128(2):876-889.


Immune checkpoint blockade in infectious diseases.
Wykes MN, Lewin SR.
Nat Rev Immunol. 2018 Feb;18(2):91-104.

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses.
Brinkmann CR, Højen JF, Rasmussen TA, Kjær AS, Olesen R, Denton PW, Østergaard L, Ouyang Z, Lichterfeld M, Yu X, Søgaard OS, Dinarello C, Tolstrup M.
mSphere. 2018 Feb 14;3(1). pii: e00616-17.


January 2018

A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.
Pankrac J, Klein K, McKay PF, King DFL, Bain K, Knapp J, Biru T, Wijewardhana CN, Pawa R, Canaday DH, Gao Y, Fidler S, Shattock RJ, Arts EJ, Mann JFS.
NPJ Vaccines. 2018 Jan 19;3:2.

Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner.
Kim JT, Chang E, Sigal A, Baltimore D.
PLoS One. 2018 Jan 2;13(1):e0189945.

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA.
Ferdin J, Goričar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M.
PLoS One. 2018 Jan 24;13(1):e0191613.

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD.
PLoS Pathog. 2018 Jan 5;14(1):e1006830.

Getting the "Kill" into "Shock and Kill": Strategies to Eliminate Latent HIV.
Kim Y, Anderson JL, Lewin SR.
Cell Host Microbe. 2018 Jan 10;23(1):14-26.

Towards a cure for human immunodeficiency virus.
Pitman MC, Lewin SR.
Intern Med J. 2018 Jan;48(1):12-15.

Digital PCR as a tool to measure HIV persistence.
Rutsaert S, Bosman K, Trypsteen W, Nijhuis M, Vandekerckhove L.
Retrovirology. 2018 Jan 30;15(1):16.


December 2017

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Gavegnano C, Brehm JH, Dupuy FP, Talla A, Ribeiro SP, Kulpa DA, Cameron C, Santos S, Hurwitz SJ, Marconi VC, Routy JP, Sabbagh L, Schinazi RF, Sékaly RP.
PLoS Pathog. 2017 Dec 21;13(12):e1006740.
Read more.

Systems serology: profiling vaccine induced humoral immunity against HIV.
Chung AW, Alter G.
Retrovirology. 2017 Dec 21;14(1):57.
Read more

A Role for Fc-Mediated Humoral Immunity in Reducing HIV Transmission Rates between HIV Serodiscordant Heterosexual Couples.
Kent SJ, Chung AW.
EBioMedicine. 2017 Dec;26:2-3.
Read more.

Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals.
Prévost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A.
Virology. 2017 Dec 14;515:38-45.
Read more.

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.
Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.
PLoS Pathog. 2017 Dec 28;13(12):e1006753.
Read more.

Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.
Admiraal R, de Koning CCH, Lindemans CA, Bierings MB, Wensing AMJ, Versluys AB, Wolfs TFW, Nierkens S, Boelens JJ.
J Allergy Clin Immunol. 2017 Dec;140(6):1643-1650.


November 2017

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes.
Burwitz BJ, Wu HL, Abdulhaqq S, Shriver-Munsch C, Swanson T, Legasse AW, Hammond KB, Junell SL, Reed JS, Bimber BN, Greene JM, Webb GM, Northrup M, Laub W, Kievit P, MacAllister R, Axthelm MK, Ducore R, Lewis A, Colgin LMA, Hobbs T, Martin LD, Ferguson B, Thomas CR Jr, Panoskaltsis-Mortari A, Meyers G, Stanton JJ, Maziarz RT, Sacha JB.
Nat Commun. 2017 Nov 10;8(1):1418.
Read more.

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG.
PLoS Med. 2017 Nov 7;14(11):e1002417.
Read more.

Mistrust and Endorsement of Human Immunodeficiency Virus Conspiracy Theories Among Human Immunodeficiency Virus-Infected African American Veterans.
Mattocks KM, Gibert C, Fiellin D, Fiellin LE, Jamison A, Brown A, Justice AC.
Mil Med. 2017 Nov;182(11):e2073-e2079.

Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
Boehm D, Ott M.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S8-S22.

An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S31-S39.

Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.
Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S40-S58.

October 2017

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N, Kaufmann DE.
Nat Protoc. 2017 Oct;12(10):2029-2049.

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.
Nat Commun. 2017 Oct 19;8(1):1049.

HIV cure research: print and online media reporting in Australia.
Power J, Fileborn B, Dowsett GW, Lucke J, Brown G, Ellard J, Lewin SR, Tucker JD, Slavin S, Sugarman J, Hill S.
J Virus Erad. 2017 Oct 1;3(4):229-235.

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.
Hiener B, Horsburgh BA, Eden JS, Barton K, Schlub TE, Lee E, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
Cell Rep. 2017 Oct 17;21(3):813-822

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.
McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, Sekaly RP, Paiardini M.
Immunity. 2017 Oct 17;47(4):776-788.

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection.
Shan L, Deng K, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, Ke R, Flavell RA, Siliciano JD, Siliciano RF.
Immunity. 2017 Oct 17;47(4):766-775.

September 2017

Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.
Julg B, Liu PT, Wagh K, Fischer WM, Abbink P, Mercado NB, Whitney JB, Nkolola JP, McMahan K, Tartaglia LJ, Borducchi EN, Khatiwada S, Kamath M, LeSuer JA, Seaman MS, Schmidt SD, Mascola JR, Burton DR, Korber BT, Barouch DH.
Sci Transl Med. 2017 Sep 20;9(408).
Read more.

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.
Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH.
Sci Transl Med. 2017 Sep 6;9(406).

Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B.
Rosás-Umbert M, Mothe B, Noguera-Julian M, Bellido R, Puertas MC, Carrillo J, Rodriguez C, Perez-Alvarez N, Cobarsí P, Gomez CE, Esteban M, Jímenez JL, García F, Blanco J, Martinez-Picado J, Paredes R, Brander C.
PLoS One. 2017 Sep 27;12(9):e0184929.

The Molecular Basis for Human Immunodeficiency Virus Latency.
Mbonye U, Karn J.
Annu Rev Virol. 2017 Sep 29;4(1):261-285.

New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV.
Carrillo MA, Zhen A, Zack JA, Kitchen SG.
Transl Res. 2017 Sep;187:83-92.
Read more.

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes.
Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M.
Mol Cell. 2017 Sep 21;67(6):1001-1012.


August 2017

Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Julg B, Pegu A, Abbink P, Liu J, Brinkman A, Molloy K, Mojta S, Chandrashekar A, Callow K, Wang K, Chen X, Schmidt SD, Huang J, Koup RA, Seaman MS, Keele BF, Mascola JR, Connors M, Barouch DH.
J Virol. 2017 Jul 27;91(16).
Read more.

Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines.
Boehm D, Ott M.
Bio Protoc. 2017 May 20;7(10).

Fcγ Receptor Function and the Design of Vaccination Strategies.
Bournazos S, Ravetch JV.
Immunity. 2017 Aug 15;47(2):224-233.

Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients.
Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F.
AIDS. 2017 Aug 24;31(13):1895-1897.
Read more.

Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types.
Yek C, Massanella M, Peling T, Lednovich K, Nair SV, Worlock A, Vargas M, Gianella S, Ellis RJ, Strain MC, Busch MP, Nugent CT, Richman DD.
J Clin Microbiol. 2017 Aug;55(8):2544-2553.

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers.
de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF, Michaud HA.
Retrovirology. 2017 Aug 22;14(1):41.


July 2017

Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.
Miller CM, Akiyama H, Agosto LM, Emery A, Ettinger CR, Swanstrom RI, Henderson AJ, Gummuluru S.
J Virol. 2017 Jun 9;91(13).

Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation.
Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D.
Sci Immunol. 2017 Jul 21;2(13).

Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.
Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM.
AIDS Res Hum Retroviruses. 2017 Jul;33(7):658-667.

HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication.
Keating SM, Pilcher CD, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP.
J Infect Dis. 2017 Jul 1;216(1):72-81.

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells.
Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR.
Cell Rep. 2017 Jul 25;20(4):984-998.

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals.
Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S, Wong JK, Hiener BM, Palmer S, Zaunders J, Post JJ, Chan DJ, Avery S, Milliken ST, Kelleher AD, Lewin SR, Cooper DA.
J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):328-337.
READ MORE: Understanding Exactly How the ‘Berlin Patient’ Was Cured

The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques.
McGary CS, Alvarez X, Harrington S, Cervasi B, Ryan ES, Iriele RI, Paganini S, Harper JL, Easley K, Silvestri G, Ansari AA, Lichterfeld M, Micci L, Paiardini M.
Mucosal Immunol. 2017 Jul;10(4):1082-1096.

Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed.
Pillai SK, Deeks SG.
Trends Immunol. 2017 Jul;38(7):457-458.


June 2017

High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay.
Yucha RW, Hobbs KS, Hanhauser E, Hogan LE, Nieves W, Ozen MO, Inci F, York V, Gibson EA, Thanh C, Shafiee H, El Assal R, Kiselinova M, Robles YP, Bae H, Leadabrand KS, Wang S, Deeks SG, Kuritzkes DR, Demirci U, Henrich TJ.
EBioMedicine. 2017 Jun;20:217-229.

BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB 3rd, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A.
J Virol. 2017 May 12;91(11).

Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.
Forsell MNE, Kvastad L, Sedimbi SK, Andersson J, Karlsson MCI.
Front Immunol. 2017 Jun 30;8:738.

New challenges in therapeutic vaccines against HIV infection.
Leal L, Lucero C, Gatell JM, Gallart T, Plana M, García F.
Expert Rev Vaccines. 2017 Jun;16(6):587-600.

Post-treatment control in an adult with perinatally acquired HIV following cessation of antiretroviral therapy.
McMahon JH, Chang J, Tennakoon S, Dantanarayana A, Solomon A, Cherry C, Doherty R, Cameron P, Lewin SR.
AIDS. 2017 Jun 1;31(9):1344-1346.

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection.
Vibholm L, Schleimann MH, Højen JF, Benfield T, Offersen R, Rasmussen K, Olesen R, Dige A, Agnholt J, Grau J, Buzon M, Wittig B, Lichterfeld M, Petersen AM, Deng X, Abdel-Mohsen M, Pillai SK, Rutsaert S, Trypsteen W, De Spiegelaere W, Vandekerchove L, Østergaard L, Rasmussen TA, Denton PW, Tolstrup M, Søgaard OS.
Clin Infect Dis. 2017 Jun 15;64(12):1686-1695.
Read more.


May 2017

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M.
Cell Host
Read more.


April 2017

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads.
Charlins P, Schmitt K, Remling-Mulder L, Hogan LE, Hanhauser E, Hobbs KS, Hecht F, Deeks SG, Henrich TJ, Akkina R.
Virology. 2017 Apr 19;507:135-139.
Read more

Signaling by Antibodies: Recent Progress.
Bournazos S, Wang TT, Dahan R, Maamary J, Ravetch JV.
Annu Rev Immunol. 2017 Apr 26;35:285-311.

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Pollack RA, Jones RB, Pertea M, Bruner KM, Martin AR, Thomas AS, Capoferri AA, Beg SA, Huang SH, Karandish S, Hao H, Halper-Stromberg E, Yong PC, Kovacs C, Benko E, Siliciano RF, Ho YC.
Cell Host Microbe. 2017 Apr 12;21(4):494-506.

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics.
Hosmane NN, Kwon KJ, Bruner KM, Capoferri AA, Beg S, Rosenbloom DI, Keele BF, Ho YC, Siliciano JD, Siliciano RF.
J Exp Med. 2017 Apr 3;214(4):959-972.

Assays for precise quantification of total (including short) and elongated HIV-1 transcripts.
Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA.
J Virol Methods. 2017 Apr;242:1-8.


March 2017

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.
Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A.
J Virol. 2017 Feb 14;91(5). pii: e02219-16.
READ MORE: Exploring the HIV Envelope in Pursuit of an HIV Vaccine

February 2017

Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection.
Tawakol A, Ishai A, Li D, Takx RA, Hur S, Kaiser Y, Pampaloni M, Rupert A, Hsu D, Sereti I, Fromentin R, Chomont N, Ganz P, Deeks SG, Hsue PY.
JAMA Cardiol. 2017 Feb 1;2(2):163-171.
READ MORE: Aging with HIV: Concerns About Accelerated Heart Disease  

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.
Nguyen K, Das B, Dobrowolski C, Karn J.
MBio. 2017 Feb 28;8(1). pii: e00133-17.


January 2017

The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure?
Deeks SG, Odorizzi PM, Sekaly RP.
J Clin Invest. 2017 Jan 3;127(1):103-105.
READ MORE: Understanding the ‘Interferon Paradox:’ A Novel Approach to Eradicating HIV

A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Bloch N, Gläsker S, Sitaram P, Hofmann H, Shepard CN, Schultz ML, Kim B, Landau NR.
J Biol Chem. 2017 Jan 20;292(3):1068-1080.

Cancer therapies in HIV cure research.
Rasmussen TA, Anderson JL, Wightman F, Lewin SR.
Curr Opin HIV AIDS. 2017 Jan;12(1):96-104.


December 2016

Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.
Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ.
Virology. 2016 Dec;499:72-81.

TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes.
Hofmann H, Vanwalscappel B, Bloch N, Landau NR.
Retrovirology. 2016 Dec 1;13(1):83.

Engineering HIV-Specific Immunity with Chimeric Antigen Receptors.
Kitchen SG, Zack JA.
AIDS Patient Care STDS. 2016 Dec;30(12):556-561.

Euphorbia Kansui Reactivates Latent HIV.
Cary DC, Fujinaga K, Peterlin BM.
PLoS One. 2016 Dec 15;11(12):e0168027

The mTOR Complex Controls HIV Latency.
Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E.
Cell Host Microbe. 2016 Dec 14;20(6):785-797.
READ MORE: Exploring the HIV Envelope in Pursuit of an HIV Vaccine

November 2016

Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus.
Ding S, Medjahed H, Prévost J, Coutu M, Xiang SH, Finzi A.
J Virol. 2016;90(22):10065-10073.


Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.
Pinzone MR, Graf E, Lynch L, McLaughlin B, Hecht FM, Connors M, Migueles SA, Hwang WT, Nunnari G, O'Doherty U.
J Virol. 2016;90(23):10436-10445.
READ MORE: Following HIV Reservoirs: Impact of ART and Its Timing


Quantitative evaluation of the antiretroviral efficacy of dolutegravir.
Laskey SB, Siliciano RF.
JCI Insight. 2016;1(19):e90033.

October 2016

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents.
Delagrèverie HM, Delaugerre C, Lewin SR, Deeks SG, Li JZ.
Open Forum Infect Dis. 2016 Oct 7;3(4):ofw189.


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.
EBioMedicine. 2016 Oct;12:208-218.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.
Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.
MBio. 2016 Oct 25;7(5). pii: e01598-16.


Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.
Mavigner M, Lee ST, Habib J, Robinson C, Silvestri G, O'Doherty U, Chahroudi A.
J Virus Erad. 2016 Oct 5;2(4):219-226.


Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay.
Trypsteen W, Mohammadi P, Van Hecke C, Mestdagh P, Lefever S, Saeys Y, De Bleser P, Vandesompele J, Ciuffi A, Vandekerckhove L, De Spiegelaere W.
Sci Rep. 2016 Oct 26;6:36111.


CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A, Yu D.
Nat Immunol. 2016 Oct;17(10):1187-96.

September 2016

Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.
Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ.
Virology. 2016 Sep 15;499:72-81.

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG, Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE.
Cell Host Microbe. 2016 Sep 14;20(3):368-80.

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.
EBioMedicine. 2016 Sep 9. pii: S2352-3964(16)30412-1. 

Standard vaccines increase HIV-1 transcription during antiretroviral therapy.
Yek C, Gianella S, Plana M, Castro P, Scheffler K, García F, Massanella M, Smith DM.
AIDS. 2016 Sep 24;30(15):2289-98.

Antiretroviral therapy suppressed participants with low CD4+ T-cell counts segregate according to opposite immunological phenotypes.
Pérez-Santiago J, Ouchi D, Urrea V, Carrillo J, Cabrera C, Villà-Freixa J, Puig J, Paredes R, Negredo E, Clotet B, Massanella M, Blanco J.
AIDS. 2016 Sep 24;30(15):2275-87.
READ MORE:  More Than One Way to Activate a Virus

Broad activation of latent HIV-1 in vivo.
Barton K, Hiener B, Winckelmann A, Rasmussen TA, Shao W, Byth K, Lanfear R, Solomon A, McMahon J, Harrington S, Buzon M, Lichterfeld M, Denton PW, Olesen R, Østergaard L, Tolstrup M, Lewin SR, Søgaard OS, Palmer S.
Nat Commun. 2016 Sep 8;7:12731.
READ MORE:  More Than One Way to Activate a Virus

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.
Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Capoferri AA, Bruner KM, Pollack RA, Zhang H, Drummond MB, Siliciano JM, Siliciano R, Stivers JT.
Elife. 2016 Sep 20;5. pii: e18447.

Defective proviruses rapidly accumulate during acute HIV-1 infection.
Bruner KM, Murray AJ, Pollack RA, Soliman MG, Laskey SB, Capoferri AA, Lai J, Strain MC, Lada SM, Hoh R, Ho YC, Richman DD, Deeks SG, Siliciano JD, Siliciano RF.
Nat Med. 2016 Sep;22(9):1043-9.

August 2016

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.
Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD.
PLoS One. 2016 Aug 2;11(8):e0160192.

Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring.
Lifson MA, Ozen MO, Inci F, Wang S, Inan H, Baday M, Henrich TJ, Demirci U.
Adv Drug Deliv Rev. 2016 Aug 1;103:90-104.

Identification of Siglec-1 null individuals infected with HIV-1.
Martinez-Picado J, McLaren PJ, Erkizia I, Martin MP, Benet S, Rotger M, Dalmau J, Ouchi D, Wolinsky SM, Penugonda S, Günthard HF, Fellay J, Carrington M, Izquierdo-Useros N, Telenti A.
Nat Commun. 2016 Aug 11;7:12412.

T-cell therapies for HIV: Preclinical successes and current clinical strategies.
Patel S, Jones RB, Nixon DF, Bollard CM.
Cytotherapy. 2016 Aug;18(8):931-42.

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality.
Laskey SB, Pohlmeyer CW, Bruner KM, Siliciano RF.
PLoS Pathog. 2016 Aug 5;12(8):e1005689.

In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
Nakaya Y, Stavrou S, Blouch K, Tattersall P, Ross SR.
J Virol. 2016 Aug 12;90(17):8005-12.

July 2016

HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-κB.
Saleh S, Lu HK, Evans V, Harisson D, Zhou J, Jaworowski A, Sallmann G, Cheong KY, Mota TM, Tennakoon S, Angelovich TA, Anderson J, Harman A, Cunningham A, Gray L, Churchill M, Mak J, Drummer H, Vatakis DN, Lewin SR, Cameron PU.
Retrovirology. 2016 Jul 26;13(1):49.

Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques.
Cartwright EK, Palesch D, Mavigner M, Paiardini M, Chahroudi A, Silvestri G.
J Virol. 2016 Jul 11;90(15):6699-708.

Animal models to achieve an HIV cure.
Kumar N, Chahroudi A, Silvestri G.
Curr Opin HIV AIDS. 2016 Jul;11(4):432-41.

Strategies for targeting residual HIV infection.
Chomont N, Perreau M.
Curr Opin HIV AIDS. 2016 Jul;11(4):359-61.

Persistent HIV-1 replication during antiretroviral therapy.
Martinez-Picado J, Deeks SG.
Curr Opin HIV AIDS. 2016 Jul;11(4):417-23.

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N.
PLoS Pathog. 2016 Jul 14;12(7):e1005761.

Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation.
Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK.
Nat Med. 2016 Jul;22(7):807-11.

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model.
Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S.
J Vis Exp. 2016 Jul 2;(113).

Shocking HIV out of hiding: where are we with clinical trials of latency reversing agents?
Rasmussen TA, Lewin SR.
Curr Opin HIV AIDS. 2016 Jul;11(4):394-401.

Adapting SHIVs In Vivo Selects for Envelope-Mediated Interferon-α Resistance.
Boyd DF, Sharma A, Humes D, Cheng-Mayer C, Overbaugh J.
PLoS Pathog. 2016 Jul 11;12(7):e1005727

The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence.
Murray AJ, Kwon KJ, Farber DL, Siliciano RF.
J Immunol. 2016 Jul 15;197(2):407-17.

Tissue reservoirs of HIV.
Wong JK, Yukl SA.
Curr Opin HIV AIDS. 2016 Jul;11(4):362-70.

June 2016

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency.
Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV.
Cell. 2016 Jun 16;165(7):1609-20.

Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART.
Dan JM, Massanella M, Smith DM, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S.
J Acquir Immune Defic Syndr. 2016 Jun 1;72(2):133-7.

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis.
Li Q, Karim AF, Ding X, Das B, Dobrowolski C, Gibson RM, Quiñones-Mateu ME, Karn J, Rojas RE.
Sci Rep. 2016 Jun 14;6:27566.

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J.
Nat Commun. 2016 Jun 28;7:12040.

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK.
PLoS Pathog. 2016 Jun 2;12(6):e1005677.

Immunologic profiles distinguish aviremic HIV-infected adults.
Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW.
AIDS. 2016 Jun 19;30(10):1553-62.

The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model.
Cadena C, Stavrou S, Manzoni T, Iyer SS, Bibollet-Ruche F, Zhang W, Hahn BH, Browne EP, Ross SR.
Retrovirology. 2016 Jun 30;13(1):45.

May 2016

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
Lu CL, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A, Ravetch JV, Caskey M, Chakraborty AK, Nussenzweig MC.
Science. 2016 May 20;352(6288):1001-4

HIV-1 Reservoirs During Suppressive Therapy.
Barton K, Winckelmann A, Palmer S.
Trends Microbiol. 2016 May;24(5):345-55.

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.
Tully DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M, Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K, McGrath G, Bazner SB, Tinsley J, Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, Jessen H, Kosakovsky Pond SL, Walker BD, Altfeld M, Carlson JM, Allen TM.
PLoS Pathog. 2016 May 10;12(5):e1005619.


April 2016

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL.
Nat Med. 2016 Apr;22(4):362-8.

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD.
PLoS Pathog. 2016 Apr 15;12(4):e1005545.

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Chen Y, Deller MC, Hao Y, Feng Y, Garces F, Wilson R, Dai K, O'Dell S, McKee K, Mascola JR, Ward AB, Wyatt RT, Li Y, Wilson IA, Zhu J, Shao Y.
Immunity. 2016 Apr 19;44(4):939-50.

How to Define the Latent Reservoir: Tools of the Trade.
Barton KM, Palmer SE.
Curr HIV/AIDS Rep. 2016 Apr;13(2):77-84.

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.
Hill AL, Rosenbloom D, Goldstein E3 Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ.
PLoS Pathog. 2016 Apr 27;12(4):e1005535.


March 2016

Residual inflammation and viral reservoirs: alliance against an HIV cure.
Massanella M, Fromentin R, Chomont N.
Curr Opin HIV AIDS. 2016 Mar;11(2):234-41.
READ MORE: Breaking a Vicious Circle - Controlling HIV Reservoirs by Targeting Inflammation

CCR5-Δ32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy.
Henrich TJ, Hanhauser E, Harrison LJ, Palmer CD, Romero-Tejeda M, Jost S, Bosch RJ, Kuritzkes DR.
J Infect Dis. 2016 Mar 1;213(5):766-70.

Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection.
Gianella S, Anderson CM, Var SR, Oliveira MF, Lada SM, Vargas MV, Massanella M, Little SJ, Richman DD, Strain MC, Pérez-Santiago J, Smith DM.
J Virol. 2016 Mar 28;90(8):3944-52.

Macrophages and HIV-1: An Unhealthy Constellation.
Sattentau QJ, Stevenson M.
Cell Host Microbe. 2016 Mar 9;19(3):304-10.


February 2016

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.
Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Lluís C, Franco R, McCormick PJ, Climent N.
J Leukoc Biol. 2016 Feb;99(2):349-59.

HIV-specific CD8+ T cells and HIV eradication.
Jones RB, Walker BD.
J Clin Invest. 2016 Feb 1;126(2):455-63.

Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.
Ryan ES, Micci L, Fromentin R, Paganini S, McGary CS, Easley K, Chomont N, Paiardini M.
PLoS Pathog. 2016 Feb 1;12(2):e1005412.
READ MORE: Attacking HIV in the Gut

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.
Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK.
J Infect Dis. 2016 Feb 1;213(3):361-9.

Recent developments in the effort to cure HIV infection: going beyond N = 1.
Siliciano JD, Siliciano RF.
J Clin Invest. 2016 Feb 1;126(2):409-14.


January 2016

Ethics of ART interruption after stem-cell transplantation.
Sugarman J, Lewin SR, Henrich TJ, Rasmussen TA.
Lancet HIV. 2016 Jan;3(1):e8-e10.
READ MORE: The Science, and Ethics, of Stopping ART in Assessing Possible HIV Cures

Analysis of HIV-1 Gag-RNA Interactions in Cells and Virions by CLIP-seq.
Kutluay SB, Bieniasz PD.
Methods Mol Biol. 2016;1354:119-31

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure.
Martin AR, Siliciano RF.
Annu Rev Med. 2016 Jan 14;67:215-28

December 2015

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.
Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK.
J Immunol. 2015 Dec 15;195(12):5625-36.

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR.
Lancet HIV. 2015 Dec;2(12):e520-9.

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1.
Rosenbloom DI, Elliott O, Hill AL, Henrich TJ, Siliciano JM, Siliciano RF. 
Open Forum Infect Dis. 2015 Aug 26;2(4):ofv123.

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.
Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M.
J Clin Invest. 2015 Dec 1;125(12):4497-513. 
READ MORE: Reducing Viral Reservoirs with Immune-Based Therapy

Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women.
Shen R, Achenbach J, Shen Y, Palaia J, Rahkola JT, Nick HJ, Smythies LE, McConnell M, Fowler MG, Smith PD, Janoff EN.
PLoS One. 2015 Dec 17;10(12):e0145150.


November 2015

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects.
Burbelo PD, Klimavicz JS, Deeks SG, Kovacs JA, Ragheb JA.
PLoS One. 2015 Nov 23;10(11):e0127662.

Multiplexed highly-accurate DNA sequencing of closely-related HIV-1 variants using continuous long reads from single molecule, real-time sequencing.
Dilernia DA, Chien JT, Monaco DC, Brown MP, Ende Z, Deymier MJ, Yue L, Paxinos EE, Allen S, Tirado-Ramos A, Hunter E.
Nucleic Acids Res. 2015 Nov 16;43(20):e129

CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.
Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM.
Cell Host Microbe. 2015 Nov 11;18(5):560-70.

Central memory CD4+ T cells are preferential targets of double infection by HIV-1.
Haqqani AA, Marek SL, Kumar J, Davenport M, Wang H, Tilton JC.
Virol J. 2015 Nov 11;12(1):184.

Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity.
Wahl A, Baker C, Spagnuolo RA, Stamper LW, Fouda GG, Permar SR, Hinde K, Kuhn L, Bode L, Aldrovandi GM, Garcia JV.
J Virol. 2015 Nov 1;89(21):10868-78.
READ MORE: Breast Milk Yields Clues to Natural Inhibitors of HIV


October 2015

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat.
Olesen R, Vigano S, Rasmussen TA, Søgaard OS, Ouyang Z, Buzon M, Bashirova A, Carrington M, Palmer S, Brinkmann CR, Yu XG, Østergaard L, Tolstrup M, Lichterfeld M. J Virol. 2015 Oct 15;89(20):10176-89 
READ MORE: A Prominent Role for Innate Immunity in Eradicating HIV

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs.
Malatinkova E, De Spiegelaere W, Bonczkowski P, Kiselinova M, Vervisch K, Trypsteen W, Johnson M, Verhofstede C, de Looze D, Murray C, Kinloch-de Loes S, Vandekerckhove L. Elife. 2015 Oct 6;4. doi: 10.7554/eLife.09115.


September 2015

Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.
Chowdhury A, Hayes TL, Bosinger SE, Lawson BO, Vanderford T, Schmitz JE, Paiardini M, Betts M, Chahroudi A, Estes JD, Silvestri G.
J Virol. 2015 Sep 1;89(17):8677-86.  
READ MORE: Taking Control of HIV

The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.
Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M.
PLoS Pathog. 2015 Sep 22;11(9):e1005149.  

HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses.
Andrés C, Plana M, Guardo AC, Alvarez-Fernández C, Climent N, Gallart T, León A, Clotet B, Autran B, Chomont N, Gatell JM, Sánchez-Palomino S, García F.
J Virol. 2015 Sep 15;89(18):9189-99.  

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir.
Bosman KJ, Nijhuis M, van Ham PM, Wensing AM, Vervisch K, Vandekerckhove L, De Spiegelaere W.
Sci Rep. 2015 Sep 9;5:13811.  

Antigen-specific NK cell memory in rhesus macaques.
Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH.
Nat Immunol. 2015 Sep;16(9):927-32;
READ MORE: Natural Killers Adapt

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.
Virology. 2015 Sep;483:185-202.

Inhibition of HIV infection by caerin 1 antimicrobial peptides.
VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
Peptides. 2015 Sep;71:296-303. doi: 10.1016/j.peptides.2015.05.004. Epub 2015 May 27.

August 2015

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S.
J Infect Dis. 2015 Aug 15;212(4):596-607
READ MORE: Division or Multiplication: Exploring the Maintenance of the HIV Reservoir  

July 2015

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency.
Mousseau G, Kessing CF, Fromentin R, Trautmann L, Chomont N, Valente ST.
MBio. 2015 Jul 7;6(4). pii: e00465-15.
READ MORE: Stabilize or Stimulate? A New Approach to Attacking the HIV Reservoir   

Robust regression methods for real-time polymerase chain reaction.
Trypsteen W, De Neve J, Bosman K, Nijhuis M, Thas O, Vandekerckhove L, De Spiegelaere W.
Anal Biochem. 2015 Jul 1;480:34-6. doi: 10.1016/j.ab.2015.04.001  

Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy.
Schafer JL, Li H, Evans TI, Estes JD, Reeves RK.
J Virol. 2015 Jul 1;89(13):6887-94.   

A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.
Seamon KJ, Stivers JT.
J Biomol Screen. 2015 Jul;20(6):801-9.

ddpcRquant: threshold determination for single channel droplet digital PCR experiments.
Trypsteen W, Vynck M, De Neve J, Bonczkowski P, Kiselinova M, Malatinkova E, Vervisch K, Thas O, Vandekerckhove L, De Spiegelaere W.
Anal Bioanal Chem. 2015 Jul;407(19):5827-34.

June 2015

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.
Mbonye UR, Wang B, Gokulrangan G, Chance MR, Karn J.
Proteomics. 2015 Jun;15(12):2078-86.

Bone Marrow-Imprinted Gut-Homing of Plasmacytoid Dendritic Cells (pDCs) in Acute Simian Immunodeficiency Virus Infection Results in Massive Accumulation of Hyperfunctional CD4+ pDCs in the Mucosae.
Li H, Evans TI, Gillis J, Connole M, Reeves RK.
J Infect Dis. 2015 Jun 1;211(11):1717-25.
READ MORE: Are Early Immune Defenses Helping HIV Flourish?  

May 2015

Animal models in HIV-1 protection and therapy.
Hessell AJ, Haigwood NL.
Curr Opin HIV AIDS. 2015 May;10(3):170-6.

Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.
Henrich TJ, Hanhauser E, Hu Z, Stellbrink HJ, Noah C, Martin JN, Deeks SG, Kuritzkes DR, Pereyra F.
AIDS. 2015 May 15;29(8):867-76.

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells.
Pino M, Erkizia I, Benet S, Erikson E, Fernández-Figueras MT, Guerrero D, Dalmau J, Ouchi D, Rausell A, Ciuffi A, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J, Izquierdo-Useros N.
Retrovirology. 2015 May 7;12:37.

CD4 mimetics sensitize HIV-1-infected cells to ADCC.
Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94.
READ MORE: Exposing HIV-Infected Cells to Antibody Attack

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.
Laird GM, Bullen CK, Rosenbloom DI, Martin AR, Hill AL, Durand CM, Siliciano JD, Siliciano RF.
J Clin Invest. 2015 May 1;125(5):1901-12.
READ MORE: To Reverse HIV Latency, Two Drugs Are Better Than One

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.
Virology. 2015 May 13;483:185-202.

April 2015

Molecular Determinants for Recognition of Divergent SAMHD1 Proteins by the Lentiviral Accessory Protein Vpx.
Schwefel D, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, Taylor IA.
Cell Host Microbe. 2015 Apr 8;17(4):489-99. 

Towards an HIV-1 cure: measuring the latent reservoir.
Bruner KM, Hosmane NN, Siliciano RF.
Trends Microbiol. 2015 Apr;23(4):192-203.
READ MORE: Better Tools Needed to Reach a Cure  

March 2015

T Memory Stem Cells and HIV: a Long-Term Relationship.
Chahroudi A, Silvestri G, Lichterfeld M.
Curr HIV/AIDS Rep. 2015 Mar;12(1):33-40. doi: 10.1007/s11904-014-0246-4.
READ MORE: Self-Sustaining Reservoirs of HIV  

February 2015

Select host restriction factors are associated with HIV persistence during antiretroviral therapy.
Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK.
AIDS. 2015 Feb 20;29(4):411-20
READ MORE: Restricting HIV Reservoir Size: Lessons from Patients

Accurate Quantification of Episomal HIV-1 Two-Long Terminal Repeat Circles by Use of Optimized DNA Isolation and Droplet Digital PCR.
Malatinkova E, Kiselinova M, Bonczkowski P, Trypsteen W, Messiaen P, Vermeire J, Verhasselt B, Vervisch K, Vandekerckhove L, De Spiegelaere W.
J Clin Microbiol. 2015 Feb;53(2):699-701.

January 2015

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?
Ananworanich J, Dubé K, Chomont N.
Curr Opin HIV AIDS. 2015 Jan;10(1):18-28.
READ MORE: Boosting Killer T cells to Eliminate HIV Reservoirs

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope.
Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR.
J Virol. 2015 Jan 15;89(2):1105-18.
NB: acknowledgement correction including amfAR:

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.
Nature. 2015 Jan 15;517(7534):381-5.
READ MORE: Boosting Killer T cells to Eliminate HIV Reservoirs  

December 2014

The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial.
Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW.
PLoS One. 2014 Dec 29;9(12):e116306.  

Macrophage Infection via Selective Capture of HIV-1-Infected CD4(+) T Cells.
Baxter AE, Russell RA, Duncan CJ, Moore MD, Willberg CB, Pablos JL, Finzi A, Kaufmann DE, Ochsenbauer C, Kappes JC, Groot F, Sattentau QJ.
Cell Host Microbe. 2014 Dec 10;16(6):711-21.  

Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents.
Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman D, Siberry GK, Van Dyke RB, Burchett S, Seage GR 3rd, Luzuriaga K; Pediatric HIV/AIDS Cohort Study.
JAMA Pediatr. 2014 Dec 1;168(12):1138-46. 

Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.
Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK.
J Infect Dis. 2014 Dec 1;210(11):1838-43.  

Plasmacytoid Dendritic Cells from HIV-1 Elite Controllers Maintain a Gut-Homing Phenotype Associated with Immune Activation.
Li H, Goepfert P, Reeves RK.
AIDS Res Hum Retroviruses. 2014 Dec;30(12):1213-5.  

HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission.
Shen R, Raska M, Bimczok D, Novak J, Smith PD.
J Virol. 2014 Dec 15;88(24):14258-67.  

A primary CD4(+) T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence.
Kim M, Hosmane NN, Bullen CK, Capoferri A, Yang HC, Siliciano JD, Siliciano RF.
Nat Protoc. 2014 Dec;9(12):2755-70.
READ MORE: Modeling and Controlling HIV  Reservoirs

Finding a Cure for Human Immunodeficiency Virus-1 Infection.
Blankson JN, Siliciano JD, Siliciano RF.
Infect Dis Clin North Am. 2014 Dec;28(4):633-650.  

Sulfonation pathway inhibitors block reactivation of latent HIV-1.
Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JA.
Virology. 2014 Dec;471-473:1-12.
READ MORE: Modeling and Controlling HIV  Reservoirs

November 2014

HIV-1 Envelope Glycoprotein Trimer Immunogenicity Elicited in the Presence of Human CD4 Alters the Neutralization Profile.
Forsell MN, McKee K, Feng Y, Mascola JR, Wyatt RT.
AIDS Res Hum Retroviruses. 2014 Nov;30(11):1089-98 

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy.
Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly RP, Lewin SR.
PLoS Pathog. 2014 Nov 13;10(10):e1004473 

Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies.
Vandergeeten C, Fromentin R, Merlini E, Lawani MB, DaFonseca S, Bakeman W, McNulty A, Ramgopal M, Michael N, Kim JH, Ananworanich J, Chomont N.
J Virol. 2014 Nov;88(21):12385-96. 

HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment.
Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, Murray D, Strain MC, Richman DD, Chun TW, Cunningham CK, Persaud D.
J Infect Dis. 2014 Nov 15;210(10):1529-38.
READ MORE: The Impact of Early Treatment on HIV Reservoirs in Children  

October 2014

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG.
Nat Chem Biol. 2014 Oct;10(10):845-52. 

CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells.
Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG.
PLoS One. 2014 Oct 23;9(10):e110731 
READ MORE: Sizing Up the HIV Reservoir

Hypogammaglobulinemia in BLT Humanized Mice - An Animal Model of Primary Antibody Deficiency
Martinez-Torres F, Nochi T, Wahl A, Garcia JV, Denton PW.
PLoS One. 2014 Oct 1;9(10):e108663.

September 2014

Lipopolysaccharide, immune activation, and liver abnormalities in HIV/hepatitis B virus (HBV)-coinfected individuals receiving HBV-active combination antiretroviral therapy.
Crane M, Avihingsanon A, Rajasuriar R, Velayudham P, Iser D, Solomon A, Sebolao B, Tran A, Spelman T, Matthews G, Cameron P, Tangkijvanich P, Dore GJ, Ruxrungtham K, Lewin SR.
J Infect Dis. 2014 Sep 1;210(5):745-51.

Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells.
Buzon MJ, Martin-Gayo E, Pereyra F, Ouyang Z, Sun H, Li JZ, Piovoso M, Shaw A, Dalmau J, Zangger N, Martinez-Picado J, Zurakowski R, Yu XG, Telenti A, Walker BD, Rosenberg ES, Lichterfeld M.
J Virol. 2014 Sep 1;88(17):10056-65.
READ MORE: Viral Reservoirs: How Low Must We Go?   

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1.
Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF.
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13475-80.
READ MORE: Viral Reservoirs: How Low Must We Go? 

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events.
Lucera MB, Tilton CA, Mao H, Dobrowolski C, Tabler CO, Haqqani AA, Karn J, Tilton JC.
J Virol. 2014 Sep 15;88(18):10803-12.

August 2014

Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM.
AIDS Res Ther. 2014 Aug 5;11:27. 

Cutting Edge: An Antibody Recognizing Ancestral Endogenous Virus Glycoproteins Mediates Antibody-Dependent Cellular Cytotoxicity on HIV-1-Infected Cells.
Michaud HA, SenGupta D, de Mulder M, Deeks SG, Martin JN, Kobie JJ, Sacha JB, Nixon DF.
J Immunol. 2014 Aug 15;193(4):1544-8.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection.
Raska M, Czernekova L, Moldoveanu Z, Zachova K, Elliott MC, Novak Z, Hall S, Hoelscher M, Maboko L, Brown R, Smith PD, Mestecky J, Novak J.
AIDS Res Ther. 2014 Aug 1;11:23.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

The use of BLT mice to investigate the immune reconstitutionin the gastrointestinal tract.
Wahl A, Garcia JV. J Immunol Methods. 410:28-33.

July 2014

Immunologic strategies for HIV-1 remission and eradication.
Barouch DH, Deeks SG.
Science. 2014 Jul 11;345(6193):169-74. 

Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease.
Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG.
AIDS. 2014 Jul 31;28(12):1749-58.   

HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.
Izquierdo-Useros N, Lorizate M, McLaren PJ, Telenti A, Kräusslich HG, Martinez-Picado J.
PLoS Pathog. 2014 Jul 17;10(7):e1004146  

Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1.
Shen R, Kappes JC, Smythies LE, Richter HE, Novak L, Smith PD.
J Virol. 2014 Jul 1;88(13):7683-8.
READ MORE: Unraveling the Mechanisms of Male-to-Female HIV Transmission  

June 2014

Prevention of HIV-1 transmission with postexposure prophylaxis after inadvertent infected blood transfusion.
Al-Hajjar SH, Frayha HH, Al-Hazmi M, Batawi R, McIntosh K, Sax PE, Al-Thawadi S, Al-Jumaah S, Busch MP, Hanhauser E, Kuritzkes DR, Li JZ, Henrich TJ.
AIDS. 2014 Jun 19;28(10):1539-41.

A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4(+) T Cells from Elite Controllers.
Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld M.
Cell Host Microbe. 2014 Jun 11;15(6):717-28.
READ MORE:   How Cells Resist HIV Infection: New Clues

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies.
Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB 3rd, Wyatt R, Sodroski J.
J Virol. 2014 Jun 15;88(12):6542-6555.

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection.
Shan L, Siliciano RF.
J Clin Invest. 2014 Jun 2;124(6):2368-71.

Quantification of Integrated HIV DNA by Repetitive-Sampling Alu-HIV PCR on the Basis of Poisson Statistics.
De Spiegelaere W, Malatinkova E, Lynch L, Van Nieuwerburgh F, Messiaen P, O'Doherty U, Vandekerckhove L.
Clin Chem. 2014 Jun;60(6):886-95.

May 2014

An Example of Genetically Distinct HIV Type 1 Variants in Cerebrospinal Fluid and Plasma During Suppressive Therapy.
Dahl V, Gisslen M, Hagberg L, Peterson J, Shao W, Spudich S, Price RW, Palmer S.
J Infect Dis. 2014 May;209(10):1618-22.

HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions.
Burbelo PD, Bayat A, Rhodes CS, Hoh R, Martin JN, Fromentin R, Chomont N, Hütter G, Kovacs JA, Deeks SG.
J Infect Dis. 2014 May;209(10):1613-7.

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG.
PLoS Pathog. 2014 May 15;10(5):e1004078

Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D.
J Virol. 2014 May;88(9):5014-28.

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H1, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20.
READ MORE: Possible New Use for an Old Antiviral Drug in Attacking Latent HIV

BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner.
Nityanandam R, Serra-Moreno R.
PLoS Pathog. 2014 May 22;10(5):e1004151

CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression.
Tabler CO, Lucera MB, Haqqani AA, McDonald DJ, Migueles SA, Connors M, Tilton JC.
J Virol. 2014 May;88(9):4976-86.

April 2014

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.
Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF.
Nat Med. 2014 Apr;20(4):425-9.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children.
Ananworanich J, Puthanakit T, Suntarattiwong P, Chokephaibulkit K, Kerr SJ, Fromentin R, Bakeman W, Intasan J, Mahanontharit A, Sirivichayakul S, Chomont N.
AIDS. 2014 Apr 24;28(7):1015-20.

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure.
Mbonye U, Karn J.
Virology. 2014 Apr;454-455C:328-339.
READ MORE: Additional Approaches to Attacking the HIV Reservoir

Positive selection of primate genes that promote HIV-1 replication.
Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL.
Virology. 2014 Apr;454-455:291-8.

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.
Laird GM, Eisele EE, Rabi SA, Nikolaeva D, Siliciano RF.
J Antimicrob Chemother. 2014 Apr;69(4):988-94.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20. doi: 10.1093/infdis/jit628. Epub 2013 Nov 25.

March 2014

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy.
Spivak AM, Andrade A, Eisele E, Hoh R, Bacchetti P, Bumpus NN, Emad F, Buckheit R 3rd, McCance-Katz EF, Lai J, Kennedy M, Chander G, Siliciano RF, Siliciano JD, Deeks SG.
Clin Infect Dis. 2014 Mar;58(6):883-90
READ MORE: Testing “Shock and Kill” 

February 2014

Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection.
Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA.
PLoS One. 2014 Feb 18;9(2):e88621
READ MORE: HIV in the Blood and Gut: Exploring the Differences   

Discordance Between Peripheral and Colonic Markers of Inflammation During Suppressive ART.
Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM.
J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):133-41.  
READ MORE: HIV in the Blood and Gut: Exploring the Differences 

HIV-1 persistence in CD4(+) T cells with stem cell-like properties.
Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M.
Nat Med. 2014 Feb;20(2):139-42. doi: 10.1038/nm.3445. Epub 2014 Jan 12. 

January 2014

Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease.
Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM.
PLoS One. 2014 Jan 21;9(1):e85613 

[The adaptation of lentiviruses to apes was a crucial step in the origin of HIV-1]. [Article in French]
Etienne L.
Med Sci (Paris). 2014 Jan;30(1):24-6

Susceptibility to CD8 T-Cell-Mediated Killing Influences the Reservoir of Latently HIV-1-Infected CD4 T Cells.
Buzon MJ, Yang Y, Ouyang Z, Sun H, Seiss K, Rogich J, Le Gall S, Pereyra F, Rosenberg ES, Yu XG, Lichterfeld M.
J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):1-9.
READ MORE: Killer Immunity and HIV Reservoirs   

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection.
Michaud HA, de Mulder M, Sengupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF.
Retrovirology. 2014 Jan 28;11(1):10. 

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.
Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.
J Antimicrob Chemother. 2014 Jan;69(1):28-33.

A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets.
Tilton CA, Tabler CO, Lucera MB, Marek SL, Haqqani AA, Tilton JC.
J Virol Methods. 2014 Jan;195:164-9.

December 2013

Evans VA, Kumar N, Filali A, Procopio FA, Yegorov O, Goulet JP, Saleh S, Haddad EK, da Fonseca Pereira C, Ellenberg PC, Sekaly RP, Cameron PU, Lewin SR.
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4(+) T Cells.
PLoS Pathog. 2013 Dec;9(12):e1003799.
READ MORE: New Clues to the Nature of HIV Reservoirs

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4987-96.
READ MORE: New Clues to the Nature of HIV Reservoirs  

November 2013

Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG.
Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
J Infect Dis. 2013 Nov 1;208(9):1436-42.
READ MORE: Building a Stronger HAART

Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
Virology. 2013 Nov;446(1-2):56-65.

Wohlfeiler D, Hecht J, Volk J, Fisher Raymond H, Kennedy T, McFarland W.
How Can We Improve Online HIV and STD Prevention for Men Who Have Sex with Men? Perspectives of Hook-Up Website Owners, Website Users, and HIV/STD Directors.
AIDS Behav. 2013 Nov;17(9):3024-33.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K.
Absence of detectable HIV-1 viremia after treatment cessation in an infant.
N Engl J Med. 2013 Nov 7;369(19):1828-35.  

October 2013

Henrich TJ, Gandhi RT.
Early treatment and HIV-1 reservoirs: a stitch in time?
J Infect Dis. 2013 Oct 15;208(8):1189-93.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.
Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers.
PLoS Pathog. 2013 Oct;9(10):e1003691.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

All-trans-retinoic acid imprints expression of the gut-homing marker α4β7 while suppressing lymph node homing of dendritic cells.
Evans TI, Reeves RK
Clin Vaccine Immunol. 2013 Oct;20(10):1642-6.

September 2013

Breton G, Chomont N, Takata H, Fromentin R, Ahlers J, Filali-Mouhim A, Riou C, Boulassel MR, Routy JP, Yassine-Diab B, Sékaly RP.
Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection.
J Immunol. 2013 Sep 1;191(5):2194-204.
READ MORE: Attacking AIDS by Attacking Inflammation

August 2013

The mongoose, the pheasant, the pox, and the retrovirus.
Etienne L, Emerman M.
PLoS Biol. 2013;11(8):e1001641.

Lanxon-Cookson EC, Swain JV, Manocheewa S, Smith RA, Maust B, Kim M, Westfall D, Rolland M, Mullins JI.
Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses.
J Virol Methods. 2013 Aug 8;194(1-2):7-13.

Tan J, Sattentau QJ.
The HIV-1-containing macrophage compartment: a perfect cellular niche?
Trends Microbiol. 2013 Aug;21(8):405-12.
READ MORE: Exploring New Cell Reservoirs for HIV  

Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, Zaia JA, Mellors JW.
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):438-41.

July 2013

Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D.
Broad protection against influenza infection by vectored immunoprophylaxis in mice.
Nat Biotechnol. 2013 Jul;31(7):647-52.  

Klatt NR, Chomont N, Douek DC, Deeks SG.
Imune activation and HIV persistence: implications for curative approaches to HIV infection.
Immunol Rev. 2013 Jul;254(1):326-42.
READ MORE: Working Towards a Cure

Chang CC, Crane M, Zhou J, Mina M, Post JJ, Cameron BA, Lloyd AR, Jaworowski A, French MA, Lewin SR.
HIV and co-infections.
Immunol Rev. 2013 Jul;254(1):114-42.

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
Sci Transl Med. 2013 Jul 10;5(193):193ra91.
READ MORE: Working Towards a Cure  

Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG.
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
J Infect Dis. 2013 Jul;208(1):50-6.
READ MORE: Working Towards a Cure   

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.
Gene Loss and Adaptation to Hominids Underlie the Ancient Origin of HIV-1.
Cell Host Microbe. 2013 Jul 17;14(1):85-92. 

Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization.
J Immunol. 2013 Jul 1;191(1):44-51. 

Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
J Immunol. 2013 Jul 1;191(1):60-9.  

Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP.
The immunological synapse: the gateway to the HIV reservoir.
Immunol Rev. 2013 Jul;254(1):305-25.
READ MORE: Working Towards a Cure  

Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG.
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43.  

Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat Struct Mol Biol. 2013 Jul;20(7):796-803.  

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.
Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis.
PLoS Pathog. 2013 Jul;9(7):e1003487. 

Siliciano JD, Siliciano RF.
HIV-1 eradication strategies: design and assessment.
Curr Opin HIV AIDS. 2013 Jul;8(4):318-25.
READ MORE: Working Towards a Cure 

June 2013

Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA 3rd, Klasse PJ, Sakmar TP, Moore JP.
Use of G-Protein-Coupled and -Uncoupled CCR5 Receptors by CCR5 Inhibitor-Resistant and -Sensitive Human Immunodeficiency Virus Type 1 Variants.
J Virol. 2013 Jun;87(12):6569-81.
READ MORE: Purging Reservoirs of HIV

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR.
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
J Infect Dis. 2013 Jun 1;207(11):1694-702.
READ MORE: Researcher Reports Two HIV Patients Showing No Signs of Virus in Wake of Stem-Cell Transplants
READ MORE: Purging Reservoirs of HIV  

Pace M, O'Doherty U.
Hematopoietic stem cells and HIV infection.
J Infect Dis. 2013 Jun 15;207(12):1790-2.

Pace MJ, Graf EH, O'Doherty U.
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.
Virology. 2013 Jun 20;441(1):18-21.
READ MORE: Purging Reservoirs of HIV   

Josefsson L, Palmer S, Faria NR, Lemey P, Casazza J, Ambrozak D, Kearney M, Shao W, Kottilil S, Sneller M, Mellors J, Coffin JM, Maldarelli F.
Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4(+) T-cells Contain One HIV-1 DNA Molecule.
PLoS Pathog. 2013 Jun;9(6):e1003432.  

Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG.
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Blood. 2013 Jun 6;121(23):4635-46.
READ MORE: Purging Reservoirs of HIV  

Shan L, Siliciano RF.
From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.
Bioessays. 2013 Jun;35(6):544-52.
READ MORE: Purging Reservoirs of HIV  

Shan L, Rabi SA, Laird GM, Eisele EE, Zhang H, Margolick JB, Siliciano RF.
A novel PCR assay for quantification of HIV-1 RNA.
J Virol. 2013 Jun;87(11):6521-5.
READ MORE: Purging Reservoirs of HIV  

May 2013

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS Pathog. 2013 May;9(5):e1003347.
READ MORE: Multi-Targeted Approaches to an HIV Cure  

Vandergeeten C, Fromentin R, Dafonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sékaly RP, Chomont N.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Blood. 2013 May 23;121(21):4321-9.  

Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription.
J Biol Chem. 2013 May 17;288(20):14400-7.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Hatano H.
Immune activation and HIV persistence: considerations for novel therapeutic interventions.
Curr Opin HIV AIDS. 2013 May;8(3):211-6.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Stone D, Kiem HP, Jerome KR.
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS. 2013 May;8(3):217-23.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ.
Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection.
PLoS One. 2013 May 6;8(5):e61383.  

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes.
PLoS Pathog. 2013 May;9(5):e1003338

April 2013

McNatt MW, Zang T, Bieniasz PD.
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathog. 2013 Apr;9(4):e1003299. 

Voit RA, McMahon MA, Sawyer SL, Porteus MH.
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Mol Ther. 2013 Apr;21(4):786-95
READ MORE: Stopping HIV Using a Cocktail of Genes Rather than Drugs 

March 2013

Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
J Virol. 2013 Mar;87(5):2549-62.  

Kutluay SB, Perez-Caballero D, Bieniasz PD.
Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection.
PLoS Pathog. 2013 Mar;9(3):e1003214. 

Palmer S.
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92. 
READ MORE: Perfecting Tools to Monitor HIV Viral Loads

February 2013

Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM.
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res Hum Retroviruses. 2013 Feb;29(2):207-14.
READ MORE: Keeping Track of HIV Reservoirs

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies.
PLoS Pathog. 2013 Feb;9(2):e1003174. 
READ MORE: Keeping Track of HIV Reservoirs  

January 2013

Ross MW, Nyoni J, Bowen AM, Williams ML, Kashiha JJ.
Sexual and geographic organization of men who have sex with men in a large East African city: opportunities for outreach.
BMJ Open. 2012 Nov 22;2(6) e001813.  

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.
Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
J Infect Dis. 2013 Jan; 207(2):213-22.
READ MORE: Controlling HIV After Stopping Antiretroviral Therapy