amfAR, The Foundation for AIDS Research

Request for Proposals: Impact Grants exploring HIV persistence and eradication

Portal Request Form Deadline: Friday, February 27, 2015, 3:00 PM ET
Letter of Intent Submission Deadline: Tuesday, March 3, 2015, 3:00 PM ET
Hardcopy of Signed Face Page By Mail: Tuesday, March 24, 2015


amfAR, The Foundation for AIDS Research, is pleased to announce the availability of funding to support research relevant to exploring HIV persistence and the potential for HIV eradication.

Total Cost Maximum: $2,000,000
Performance Period: 4 years (July 1, 2015 – June 30, 2019)

amfAR has established a new funding mechanism known as Impact Grants to support the in-depth development of concepts where preliminary data have indicated genuine promise in curing HIV. Impact Grants are conducted over a four-year funding period with up to $2,000,000 in total funding (including up to 20% indirect costs) and should include basic, animal and clinical (in vivo or ex vivo) research. Impact Grants aim to directly inform clinical efforts to safely eliminate or control latent/persistent HIV reservoirs. Priority will be given to projects with a clear pathway to development of an implementable intervention in humans.

Topics that will not be considered include but are not limited to:

  • Socio-behavioral science
  • Prevention of HIV infection

All of the following must be incorporated into Impact Grant proposals:

  • Collaboration between institutions.
  • Basic research studies using appropriate in vitro or ex vivo techniques. Attempts to validate existing in vitro or ex vivo models, and to develop new models, including animal systems, are also encouraged.
  • In vivo studies involving nonhuman primates or other appropriate animal models.
  • A clinical (ex vivo and/or in vivo) research component.

Applicants are especially encouraged to design research studies in which Impact Grant funding will generate basic science findings that are tested clinically (i.e., bench-to-bedside research).


  • The application process has two steps: Letter of Intent (LOI) and full application. Submission of an LOI is not a guarantee of eligibility to submit a full application. The pre-application process is highly competitive. Only a limited number of investigators submitting an LOI will be invited to submit a full application.
  • Applicants may email inquiries to amfAR during the development of research plans to ensure that such plans fit within amfAR’s intended scope. No phone calls will be accepted. Please email inquiries to


Principal investigators:

  • Must hold a doctoral-level degree
  • Must hold a faculty-level position
  • Must be affiliated with the applicant institution
  • The principal investigator will be expected to coordinate the development, implementation and analysis of the collaboration as a whole, and be responsible for overall financial management and the preparation and submission of required reports.

Institutions:  Applications are accepted from nonprofit research institutions worldwide; applications are not accepted from individuals or for-profit entities. However, research teams may include members from, and budgets may include subcontracts or subawards to, for-profit entities.

Submission Requirements and Deadlines

Submission of Letters of Intent and applications is conducted via an online portal. amfAR will provide usernames and passwords to applicants. To obtain these credentials, CLICK HERE to download the request form. Complete the form and email it to

Log-in credentials are not transferable and should not be shared with others. A separate form request must be sent for each potential applicant.

You must request log-in credentials no later than 3:00 PM ET on Friday, February 27, 2015.

LOI submission deadline: Tuesday, March 3, 2015, 3:00 PM ET

Hard copy of signed face page: Tuesday, March 24, 2015

Other Important Dates:
Applications invited:
March 30, 2015 (tentative)

E-mailed application submissions due:
May 7, 2015 (tentative)

Funding decisions announced:
Late June, 2015 (tentative)


Future requests for proposals:
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