amfAR, The Foundation for AIDS Research

Publications from amfAR Grantees and Fellows (2012-2004)

Publications from amfAR Grantees and Fellows


November 2012


Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY.
A Randomized Controlled Trial Assessing the Effects of Raltegravir Intensification on Endothelial Function in Treated HIV Infection.
J Acquir Immune Defic Syndr. 2012 Nov 1;61(3):317-25.


Nyoni J, Ross MW.
Factors associated with HIV testing in men who have sex with men, in Dar es Salaam, Tanzania.
Sex Transm Infect. 2012 Nov;88(7):483.
READ MORE: Increasing HIV Testing Among MSM in Africa


Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
AIDS. 2012 Nov 28;26(18):2295-2306.


Routy JP, Angel JB, Spaans JN, Trottier B, Rouleau D, Baril JG, Harris M, Trottier S, Singer J, Chomont N, Sékaly RP, Tremblay CL.
Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV Reservoir.
HIV Clin Trials. 2012 Nov-Dec;13(6):301-7.


October 2012


Schrijvers R, Vets S, De Rijck J Malani N, Bushman FD, Debyser Z, Gijsbers R.
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.
Retrovirology. 2012 Oct 9;9:84. doi: 10.1186/1742-4690-9-84.
READ MORE: Exploring Potential New Targets for Anti-HIV Drugs  

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746.

Koh Fujinaga, Matjaz Barboric, Qintong Li, Zeping Luo, David H. Price and
B. Matija Peterlin.
PKC phosphorylates HEXIM1 and regulates P-TEFb activity.
Nucleic Acids Research, 2012, Vol. 40, No. 18: 9160-9170.
No abstract available


September 2012


Patel ES, Chang LJ.
Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling in Human T Cell Development.
J J Biol Chem. 2012 Sep 28;287(40):33826-35.


Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.
Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding.
J Virol. 2012 Sep;86(17):8974-86.


Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR.
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections.
J Virol. 2012 Sep;86(17):8920-36.
READ MORE: Potential Cures for Other Viral Infections


Praditpornsilpa K, Avihingsanon A, Chaiwatanarat T, Chaiyahong P, Wongsabut J, Ubolyam S, Chulakadabba A, Avihingsanon Y, Ruxrungtham K, Tunsanga K, Eiam-Ong S,
Phanuphak P.
Comparisons Between Validated Estimated Glomerular Filtration Rate Equations and Isotopic Glomerular Filtration Rate in HIV Patients.
J AIDS. 2012 Sep 10;26(14):1781-8.


Eisele E, Siliciano RF.
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication.
Immunity. 2012 Sep 21;37(3):377-88.



August 2012


Sigal A, Baltimore D.
As good as it gets? The problem of HIV persistence despite antiretroviral drugs.
Cell Host Microbe. 2012 Aug 16;12(2):132-8.


July 2012


Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S.
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.
J Infect Dis. 2012 Jul 1;206(1):28-34.
READ MORE: Defining HIV Reservoirs

Hogue IB, Llewellyn GN, Ono A.
Dynamic Association between HIV-1 Gag and Membrane Domains.
Mol Biol Int. 2012;2012:979765. Epub 2012 Jul 5.


May 2012


Merchant RC, Waxman MJ, Maher JG, Clark MA, Celada MT, Liu T, Simmons EM, Beckwith CG, Mayer KH.
Patient and Clinician Ethical Perspectives on the 2006 Centers for Disease Control and Prevention HIV Testing Methods.
Public Health Rep. 2012 May;127(3):318-29.
READ MORE: The Ethics of New HIV Testing Methods


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


April 2012


Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM.
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes Immun. 2012 Apr;13(3):258-67.


Gilchrist G, Blazquez A, Torrens, M.
Exploring the relationship between intimate partner violence, childhood abuse and psychiatric disorders among female drug users in Barcelona.
Advances in Dual Diagnosis. 2012 Apr;5(2):46-58.


Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.


Tun W, Kellerman S, Maimane S, Fipaza Z, Sheehy M, Vu L, Nel D.
HIV-related conspiracy beliefs and its relationships with HIV testing and unprotected sex among men who have sex with men in Tshwane (Pretoria), South Africa.
AIDS Care. 2012 Apr;24(4):459-67.
READ MORE: Homophobia and the Spread of HIV in South Africa


Vu L, Tun W, Sheehy M, Nel D.
Levels and correlates of internalized homophobia among men who have sex with men in Pretoria, South Africa.
AIDS Behav. 2012 Apr;16(3):717-23.
READ MORE: Homophobia and the Spread of HIV in South Africa


March 2012

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.
LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs.
PLoS Pathog. 2012 Mar;8(3):e1002558.


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


Melchers M, Bontjer I, Tong T, Chung NP, Klasse PJ, Eggink D, Montefiori DC, Gentile M, Cerutti A, Olson WC, Berkhout B, Binley JM, Moore JP, Sanders RW.
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
J Virol. 2012 Mar;86(5):2488-500.


Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF.
Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation.
immunity. 2012 Mar 23;36(3):491-501.
READ MORE: Destroying HIV Reservoirs


Tyagi M, Kashanchi F.
New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.
Retrovirology. 2012 Mar 9;9:19.



February 2012


Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T, Yokoyama S, Aiken C, Diaz-Griffero F.
RING domain mutations uncouple TRIM5a restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.
J Virol. 2012 Feb;86(3):1717-27.


Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F.
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Nat Immunol. 2012 Feb 12;13(3):223-8.


Kiem HP, Jerome KR, Deeks SG, McCune JM.
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Cell Stem Cell. 2012 Feb 3;10(2):137-47.
READ MORE: Leading the Charge in Cure Research


Banerjee K, Michael E, Eggink D, van Montfort T, Lasnik AB, Palmer KE, Sanders RW, Moore JP, Klasse PJ.
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice.
AIDS Res Hum Retroviruses. 2012 Feb;28(2):206-14.


Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF.
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
J Antimicrob Chemother. 2012 Feb;67(2):398-403.
READ MORE: Leading the Charge in Cure Research



January 2012


Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV.
Generation of HIV latency in humanized BLT mice.
J Virol. 2012 Jan;86(1):630-4.


Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, Kodama EI, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res. 2012 Jan 1;40(1):345-359.


Routy J, Tremblay C, Angel J, Trottier B, Rouleau D, Baril J, Harris M, Trottier S, Singer J, Chomont N, Sékaly R, Boulassel M.
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.
HIV Med. 2012 Jan 26.
READ MORE: “Shock and Kill” Strategy Holds Promise in the Search for a Cure


Boulassel MR, Chomont N, Pai NP, Gilmore N, Sékaly RP, Routy JP.
CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.
J Clin Virol. 2012 Jan;53(1):29-32.



Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff.

2011 Publications

DEC 2011

Dahl V, Lee E, Peterson J, Spudich SS, Leppla I, Sinclair E, Fuchs D, Palmer S, Price RW.
Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy.
J Infect Dis. 2011 Dec 15;204(12):1936-45.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.
Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting.
J Biol Chem. 2011 Dec 2;286(48):41812-25.

Vissman AT, Hergenrather KC, Rojas G, Langdon SE, Wilkin AM, Rhodes SD.
Applying the theory of planned behavior to explore HAART adherence among HIV-positive immigrant Latinos: elicitation interview results.
Patient Educ Couns. 2011 Dec;85(3):454-60.
READ MORE: Adhering to HAART: Challenges for Immigrant Latinos

Han K, Lou DI, Sawyer SL.
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes.
PLoS Genet. 2011 Dec;7(12):e1002388.


NOV 2011

Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB 3rd, Sodroski JG.
An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors.
PLoS One. 2011;6(11):e26731.

Gilchrist G, Blazquez A, Torrens M.
Psychiatric, behavioural and social risk factors for HIV infection among female drug users.
AIDS Behav. 2011 Nov;15(8):1834-43.
READ MORE: Gender-Based Risks for HIV among Drug Users

Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS.
Liposomes for HIV prophylaxis.
Biomaterials. 2011 Nov;32(33):8663-8.

van Montfort T, Eggink D, Boot M, Tuen M, Hioe CE, Berkhout B, Sanders RW.
HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Antigen Presentation.
J Immunol. 2011 Nov 1;187(9):4676-85.


OCT 2011

Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V.
Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells.
PLoS Pathog. 2011 Oct;7(10):e1002288.
READ MORE: New Insights Into Hidden Reservoirs for HIV Infection

Hogue IB, Grover JR, Soheilian F, Nagashima K, Ono A.
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.
J Virol. 2011 Oct;85(19):9749-66.

Saleh S, Wightman F, Ramanayake S, Alexander M, Kumar N, Khoury G, Pereira C, Purcell D, Cameron PU, Lewin SR.
Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells.
Retrovirology. 2011 Oct 12;8:80.

Eggink D, Bontjer I, Langedijk JP, Berkhout B, Sanders RW.
Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function.
J Virol. 2011 Oct;85(20):10785-97. 

SEP 2011

Lienlaf M, Hayashi F, Di Nunzio F, Tochio N, Kigawa T, Yokoyama S, Diaz-Griffero F.
Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.
J Virol. 2011 Sep;85(17):8725-37.

Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS.
Liposomes for HIV prophylaxis.
Biomaterials. 2011 Nov;32(33):8663-8.
READ MORE: A New Type of Vaginal Microbicide


AUG 2011

Pandrea I, Gaufin T, Gautam R, Kristoff J, Mandell D, Montefiori D, Keele BF, Ribeiro RM, Veazey RS, Apetrei C.
Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4 T Cells and Is Reverted by CD8 Cell Depletion.
PLoS Pathog. 2011 Aug;7(8):e1002170
READ MORE: An Animal Model for a Functional Cure for AIDS

Berro R, Klasse PJ, Lascano D, Flegler A, Nagashima KA, Sanders RW, Sakmar TP, Hope TJ, Moore JP.
Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors.
J Virol. 2011 Aug;85(16):8227-40.

Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV.
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
J Virol. 2011 Aug;85(15):7582-93.

Jin J, Li F, Mothes W.
Viral determinants of polarized assembly for the murine leukemia virus.
J Virol. 2011 Aug;85(15):7672-82.

Herbeck JT, Rolland M, Liu Y, McLaughlin S, McNevin J, Zhao H, Wong K, Stoddard JN, Raugi D, Sorensen S, Genowati I, Birditt B, McKay A, Diem K, Maust BS, Deng W, Collier AC, Stekler JD, McElrath MJ, Mullins JI.
Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes.
J Virol. 2011 Aug;85(15):7523-34

Sanders RW.
Clinical evaluation of a soluble trimeric HIV-1 envelope glycoprotein vaccine.
Expert Rev Vaccines. 2011 Aug;10(8):1117-22.

JUL 2011

Kim YK, Mbonye U, Hokello J, Karn J.
T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway.
J Mol Biol. 2011 Jul 29;410(5):896-916.

Chukkapalli V, Ono A.
Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag.
J Mol Biol. 2011 Jul 22;410(4):512-24.

Josefsson L, King MS, Makitalo B, Brännström J, Shao W, Maldarelli F, Kearney MF, Hu WS, Chen J, Gaines H, Mellors JW, Albert J, Coffin JM, Palmer SE.
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Proc Natl Acad Sci U S A. 2011 July 5;108(27):11199-204.

Tyagi S, Ochem A, Tyagi M.
DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression.
J Gen Virol. 2011 Jul;92(Pt 7):1710-20.


JUN 2011

Meade CS, Lowen SB, MacLean RR, Key MD, Lukas SE.
fMRI brain activation during a delay discounting task in HIV-positive adults with and without cocaine dependence.
Psychiatry Res. 2011 Jun 30;192(3):167-75.
READ MORE: Does Cocaine Increase the Threat of HIV?

Xing S, Bullen CK, Shroff NS, Shan L, Yang HC, Manucci JL, Bhat S, Zhang H, Margolick JB, Quinn TC, Margolis DM, Siliciano JD, Siliciano RF.
Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation.
J Virol. 2011 Jun;85(12):6060-4


APR 2011

Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG.
A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.
J Infect Dis. 2011 Apr 1;203(7):960-8.

Meade CS, Conn NA, Skalski LM, Safren SA.
Neurocognitive impairment and medication adherence in HIV patients with and without cocaine dependence.
J Behav Med. 2011 Apr;34(2):128-38.

Celada MT, Merchant RC, Waxman MJ, Sherwin AM.
An Ethical Evaluation of the 2006 Centers for Disease Control and Prevention Recommendations for HIV Testing in Health Care Settings.
Am J Bioeth. 2011 Apr;11(4):31-40.
READ MORE: The Ethics of Universal HIV Screening

Monde K, Chukkapalli V, Ono A.
Assembly and Replication of HIV-1 in T Cells with Low Levels of Phosphatidylinositol-(4,5)-Bisphosphate
J. Virol. 2011;85 3584-3595

Sungkanuparph S, Oyomopito R, Sirivichayakul S, Sirisanthana T, Li PC, Kantipong P, Lee CK, Kamarulzaman A, Messerschmidt L, Law MG, Phanuphak P; on behalf of the TREAT Asia Studies to Evaluate Resistance-Monitoring Study (TASER-M). 
HIV-1 Drug Resistance Mutations Among Antiretroviral-Naive HIV-1-Infected Patients in Asia: Results From the TREAT Asia Studies to Evaluate Resistance-Monitoring Study.
Clin Infect Dis. 2011 Apr;52(8):1053-1057.

MAR 2011

Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J, McNeely M, Hofkens J, Debyser Z, Engelborghs Y.
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering.
Nucleic Acids Res. 2011 Mar 1;39(4):1310-25.

Hunt PW, Hatano H, Sinclair E, Lee TH, Busch MP, Martin JN, McCune JM, Deeks SG.
HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.
Clin Infect Dis. 2011 Mar;52(5):681-7.

Olesen R, Wahl A, Denton PW, Victor Garcia J.
Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection.
J Reprod Immunol. 2011 Mar;88(2):195-203.
READ MORE: Can “Humanized” Mice Advance HIV Prevention?


FEB 2011

Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM.
HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells.
Blood. 2011 Feb 17;117(7):2189-99.
READ MORE: Focusing on CD8: The “Other T Cell” in HIV Infection


JAN 2011

Bosque A, Planelles V.
Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells.
Methods. 2011 Jan;53(1):54-61.
READ MORE: In the Lab, Recreating HIV’s Hidden Reservoirs

Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG.
A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers.
PLoS One. 2011 Jan 31;6(1):e15924.

Thys W, De Houwer S, Demeulemeester J, Taltynov O, Vancraenenbroeck R, Gérard M, De Rijck J, Gijsbers R, Christ F, Debyser Z.
Interplay between HIV Entry and Transportin-SR2 Dependency.
Retrovirology. 2011 Jan 30;8(1):7.

Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS.
Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms.
J Virol. 2011 Jan;85(1):43-50.

Chomont N, Dafonseca S, Vandergeeten C, Ancuta P, Sékaly RP.
Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV.
Curr Opin HIV AIDS. 2011 Jan;6(1):30-6.

2010 Publications

DEC 2010

Ling B, Mohan M, Lackner AA, Green LC, Marx PA, Doyle LA, Veazey RS.
The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection.
J Infect Dis. 2010 Dec 15;202(12):1846-54.

Josefsson L, Dahl V, Palmer S.
Can HIV infection be eradicated through use of potent antiviral agents?
Curr Opin Infect Dis. 2010 Dec;23(6):628-32.


NOV 2010

Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.
HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses.
J Virol. 2010 Nov;84(21):11020-9.
READ MORE: The HIV “Elites:” Viral Controllers and Their Genes 


OCT 2010

De Rijck J, Bartholomeeusen K, Ceulemans H, Debyser Z, Gijsbers R.
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.
Nucleic Acids Res. 2010 Oct;38(18):6135-47.

Boutwell CL, Rolland MM, Herbeck JT, Mullins JI, Allen TM.
Viral evolution and escape during acute HIV-1 infection.
J Infect Dis. 2010 Oct 15;202 Suppl 2:S309-14.
READ MORE: HIV vs. the Immune System: Early Viral Mutations May Hold Clues for Vaccine Development

Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL.
Ancient and recent adaptive evolution of primate non-homologous end joining genes.
PLoS Genet. 2010 Oct 21;6(10):e1001169.

SEP 2010

Dinkins C, Arko-Mensah J, Deretic V.
Autophagy and HIV.
Semin Cell Dev Biol. 2010 Sep;21(7):712-8.

Mothes W, Sherer NM, Jin J, Zhong P.
Virus cell-to-cell transmission.
J Virol. 2010 Sep;84(17):8360-8.

Lassen KG, Wissing S, Lobritz MA, Santiago M, Greene WC.
Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.
J Biol Chem. 2010 Sep 17;285(38):29326-35.

Arnott A, Jardine D, Wilson K, Gorry PR, Merlin K, Grey P, Law MG, Dax EM, Kelleher AD, Smith DE, McPhee DA; Pulse Study Team.
High viral fitness during acute HIV-1 infection.
PLoS One. 2010 Sep 9;5(9). pii: e12631.
READ MORE: The Changeable Fitness of HIV: Implications for Early Treatment

Rolland M, Carlson JM, Manocheewa S, Swain JV, Lanxon-Cookson E, Deng W, Rousseau CM, Raugi DN, Learn GH, Maust BS, Coovadia H, Ndung'u T, Goulder PJ, Walker BD, Brander C, Heckerman DE, Mullins JI.
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PLoS One. 2010 Sep 1;5(9). pii: e12463.


AUG 2010

O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D.
Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations.
PLoS One. 2010 Aug 6;5(8):e12009.

Deeks SG, McCune JM.
Can HIV be cured with stem cell therapy?
Nat Biotechnol. 2010 Aug;28(8):807-10.
READ MORE: Gene Therapy and the Potential for an HIV Cure

Gwadz MV, Cleland CM, Quiles R, Nish D, Welch J, Michaels LS, Gonzalez JL, Ritchie AS, Leonard NR.
CDC HIV testing guidelines and the rapid and conventional testing practices of homeless youth.
AIDS Educ Prev. 2010 Aug;22(4):312-27.

Ha TH, Liu H, Liu H, Cai Y, Feng T.
Concurrent sexual partnerships among men who have sex with men in Shenzhen, China.
Sex Transm Dis. 2010 Aug;37(8):506-11.


JUL 2010

Ances BM, Christensen JJ, Teshome M, Taylor J, Xiong C, Aldea P, Fagan AM, Holtzman DM, Morris JC, Mintun MA, Clifford DB.
Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study.
Neurology. 2010 Jul 13;75(2):111-5.

Merchant RC, Waxman MJ.
HIV screening in health care settings: some progress, even more questions.
JAMA. 2010 Jul 21;304(3):348-9.
READ MORE: The Promise and Challenges of Universal HIV Screening


JUN 2010

Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.
Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.
J Biol Chem. 2010 Jun 25;285(26):20303-15.

Javanbakht M, Guerry S, Gorbach PM, Stirland A, Chien M, Anton P, Kerndt PR.
Prevalence and correlates of heterosexual anal intercourse among clients attending public sexually transmitted disease clinics in Los Angeles County.
Sex Transm Dis. 2010 Jun;37(6):369-76.
READ MORE: Heterosexual Anal Sex: Implications for HIV Prevention

Eggink D, Melchers M, Wuhrer M, van Montfort T, Dey AK, Naaijkens BA, David KB, Le Douce V, Deelder AM, Kang K, Olson WC, Berkhout B, Hokke CH, Moore JP, Sanders RW.
Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function.
Virology. 2010 Jun 5;401(2):236-47.

Binley JM, Ban YE, Crooks ET, Eggink D, Osawa K, Schief WR, Sanders RW.
Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization.
J Virol. 2010 Jun;84(11):5637-55.


MAY 2010

Owen RE, Heitman JW, Hirschkorn DF, Lanteri MC, Biswas HH, Martin JN, Krone MR, Deeks SG, Norris PJ; NIAID Center for HIV/AIDS Vaccine Immunology.
HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.
AIDS. 2010 May 15;24(8):1095-105.

Götte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF.
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochim Biophys Acta. 2010 May;1804(5):1202-12.
READ MORE: New Insights into Old Drug Classes

APR 2010

Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS.
Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
AIDS. 2010 Apr 24;24(7):1001-5.

Deretic V.
Autophagy in infection.
Curr Opin Cell Biol. 2010 Apr;22(2):252-62.

Buzón MJ, Massanella M, Llibre JM, Esteve A, Dahl V, Puertas MC, Gatell JM, Domingo P, Paredes R, Sharkey M, Palmer S, Stevenson M, Clotet B, Blanco J, Martinez-Picado J.
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.
Nat Med. 2010 Apr;16(4):460-5.
READ MORE: Reducing HIV Growth to Zero


MAR 2010

Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VN.
Flexible use of nuclear import pathways by HIV-1.
Cell Host Microbe. 2010 Mar 18;7(3):221-33.
READ MORE: Keeping HIV Out of a Cell’s Nucleus

Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman FD, Debyser Z.
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.
Mol Ther. 2010 Mar;18(3):552-60.

Ono A.
Relationships between plasma membrane microdomains and HIV-1 assembly.
Biol Cell. 2010 Mar 25;102(6):335-50.

Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M.
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Cell Host Microbe. 2010 Mar 18;7(3):234-44.


FEB 2010

Gosselin A, Monteiro P, Chomont N, Diaz-Griffero F, Said EA, Fonseca S, Wacleche V, El-Far M, Boulassel MR, Routy JP, Sekaly RP, Ancuta P.
Peripheral blood CCR4+ CCR6+ and CXCR3+ CCR6+ CD4+ T cells are highly permissive to HIV-1 infection.
J Immunol. 2010 Feb 1;184(3):1604-16.
READ MORE: Defining the Key Targets of HIV Infection


JAN 2010

Ances BM, Greenberg JH, Detre JA.
Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
Brain Res. 2010 Jan 14;1309:19-28.

Denton PW, Krisko JF, Powell DA, Mathias M, Kwak YT, Martinez-Torres F, Zou W, Payne DA, Estes JD, Garcia JV.
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.
PLoS One. 2010 Jan 21;5(1):e8829.
READ MORE: The Promise of PrEP: Using Antiretrovirals to Prevent HIV Infection


2009 Publications

DEC 2009

Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG.

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
J Biol Chem. 2009 Dec 18;284(51):35681-91.
READ MORE: Surprising Keys to a New Anti-HIV Compound  


NOV 2009

Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE.
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.
Retrovirology. 2009 Nov 4;6:101.
READ MORE: Animal Model Enables Researchers to Track the Evolution of HIV

Jouvenet N, Simon SM, Bieniasz PD.
Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles.
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19114-9.

OCT 2009

Choi AI, Shlipak MG, Hunt PW, Martin JN, Deeks SG.
HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy.
AIDS. 2009 Oct 23;23(16):2143-9.
READ MORE: HIV, HAART, and the Kidneys

Diaz-Griffero F, Qin XR, Hayashi F, Kigawa T, Finzi A, Sarnak Z, Lienlaf M, Yokoyama S, Sodroski J.
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.
J Virol. 2009 Oct;83(20):10737-51.

Liu H, Feng T, Liu H, Feng H, Cai Y, Rhodes AG, Grusky O.
Egocentric networks of Chinese men who have sex with men: network components, condom use norms, and safer sex.
AIDS Patient Care STDS. 2009 Oct;23(10):885-93.

Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M.
Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.
J Virol. 2009 Oct;83(19):9694-708.

Sayles JN, Wong MD, Kinsler JJ, Martins D, Cunningham WE.
The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV/AIDS.
J Gen Intern Med. 2009 Oct;24(10):1101-8.


SEP 2009

Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, Buxton RB, Benson D, Smith DM, Little SJ, Richman DD, Moore DJ, Ellis RJ; HNRC group.
Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain.
Neurology. 2009 Sep 1;73(9):702-8.

Archin NM, Keedy KS, Espeseth A, Dang H, Hazuda DJ, Margolis DM.
Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors.
AIDS. 2009 Sep 10;23(14):1799-806.
READ MORE: In Search of a Cure: Working to Turn On HIV

Eggink D, Langedijk JP, Bonvin AM, Deng Y, Lu M, Berkhout B, Sanders RW.
Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.
J Biol Chem. 2009 Sep 25;284(39):26941-50.

Shehu-Xhilaga M, Rhodes D, Wightman F, Liu HB, Solomon A, Saleh S, Dear AE, Cameron PU, Lewin SR.
The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.
AIDS. 2009 Sep 24;23(15):2047-50.
READ MORE: In Search of a Cure: Working to Turn On HIV


AUG 2009

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.
Nat Med. 2009 Aug;15(8):893-900.
READ MORE: Eradicating HIV—amfAR-Funded Researchers Shed New Light on HIV Persistence

Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC.
HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.
PLoS One. 2009 Aug 7;4(8):e6551.

Liu H, Liu H, Cai Y, Rhodes AG, Hong F.
Money boys, HIV risks, and the associations between norms and safer sex: a respondent-driven sampling study in Shenzhen, China.
AIDS Behav. 2009 Aug;13(4):652-62.
READ MORE: Money Boys and the Spread of HIV in China


JUL 2009

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V.
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
J Cell Biol. 2009 Jul 27;186(2):255-68.

Jin J, Sherer NM, Heidecker G, Derse D, Mothes W.
Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.
PLoS Biol. 2009 Jul;7(7):e1000163.


JUN 2009

Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, Martin JN, Deeks SG.
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.
AIDS. 2009 Jun 1;23(9):1059-67.
READ MORE: HIV, HAART, and the Heart

Deretic V, Levine B.
Autophagy, immunity, and microbial adaptations.
Cell Host Microbe. 2009 Jun 18;5(6):527-49.


MAY 2009

Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK.
Host cell factors in HIV replication: meta-analysis of genome-wide studies.
PLoS Pathog. 2009 May;5(5):e1000437.

Ince WL, Harrington PR, Schnell GL, Patel-Chhabra M, Burch CL, Menezes P, Price RW, Eron JJ Jr, Swanstrom RI.
Major coexisting human immunodeficiency virus type 1 env gene subpopulations in the peripheral blood are produced by cells with similar turnover rates and show little evidence of genetic compartmentalization.
J Virol. 2009 May;83(9):4068-80.

Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ.
Reverse transcriptase inhibitors as potential colorectal microbicides.
Antimicrob Agents Chemother. 2009 May;53(5):1797-807.
READ MORE: Studying and Stopping Rectal Transmission of HIV

Keele BF, Li H, Learn GH, Hraber P, Giorgi EE, Grayson T, Sun C, Chen Y, Yeh WW, Letvin NL, Mascola JR, Nabel GJ, Haynes BF, Bhattacharya T, Perelson AS, Korber BT, Hahn BH, Shaw GM.
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
J Exp Med. 2009 May 11;206(5):1117-34.
READ MORE: Studying and Stopping Rectal Transmission of HIV


APR 2009

Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB.
Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation.
Hum Brain Mapp. 2009 Apr;30(4):1120-32.

Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control.
Blood. 2009 Apr 23;113(17):3978-89.

Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH, Athreya GS, Treurnicht FK, Keele BF, Wood N, Salazar-Gonzalez JF, Bhattacharya T, Chu H, Hoffman I, Galvin S, Mapanje C, Kazembe P, Thebus R, Fiscus S, Hide W, Cohen MS, Karim SA, Haynes BF, Shaw GM, Hahn BH, Korber BT, Swanstrom R, Williamson C; CAPRISA Acute Infection Study Team; Center for HIV-AIDS Vaccine Immunology Consortium.
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.
J Virol. 2009 Apr;83(8):3556-67.

Loh L, Reece JC, Fernandez CS, Alcantara S, Center R, Howard J, Purcell DF, Balamurali M, Petravic J, Davenport MP, Kent SJ.
Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.
PLoS Pathog. 2009 Apr;5(4):e1000378.

Lassen KG, Lobritz MA, Bailey JR, Johnston S, Nguyen S, Lee B, Chou T, Siliciano RF, Markowitz M, Arts EJ.
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
PLoS Pathog. 2009 Apr;5(4):e1000377.

Meade CS, Hansen NB, Kochman A, Sikkema KJ.
Utilization of medical treatments and adherence to antiretroviral therapy among HIV-positive adults with histories of childhood sexual abuse.
AIDS Patient Care STDS. 2009 Apr;23(4):259-66.
READ MORE: Optimizing Adherence in Adult Survivors of Childhood Sexual Abuse



MAR 2009

Hatziioannou T, Ambrose Z, Chung NP, Piatak M Jr, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD.
A macaque model of HIV-1 infection.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4425-9.
READ MORE: Monkeying Around With Genes Leads to Effective Simian Model

D'Orso I, Frankel AD.
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex.
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3101-6.

Huthoff H, Autore F, Gallois-Montbrun S, Fraternali F, Malim MH.
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.
PLoS Pathog. 2009 Mar;5(3):e1000330.

FEB 2009

Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y, McNatt M, Hatziioannou T, Bieniasz PD.
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.
J Virol. 2009 Feb;83(4):1837-44.
READ MORE: Tying Up HIV With Tetherin

Liu H, Feng T, Rhodes AG, Liu H.
Assessment of the Chinese version of HIV and homosexuality related stigma scales.
Sex Transm Infect. 2009 Feb;85(1):65-9.


JAN 2009

Haaland RE, Hawkins PA, Salazar-Gonzalez J, Johnson A, Tichacek A, Karita E, Manigart O, Mulenga J, Keele BF, Shaw GM, Hahn BH, Allen SA, Derdeyn CA, Hunter E.
Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.
PLoS Pathog. 2009 Jan;5(1):e1000274.

Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E.
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
J Mol Biol. 2009 Jan 23;385(3):693-713.

Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D.
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.
Cell Host Microbe. 2009 Jan 22;5(1):84-94.
READ MORE:  The Promise of an Effective Vaginal Microbicide

Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW.
Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.
J Virol. 2009 Jan;83(1):368-83.

2008 Publications

DEC 2008

Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J.
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency.
J Virol. 2008 Dec;82(24):12291-303.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF.
RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.
J Virol. 2008 Dec;82(24):12145-53.


NOV 2008

Sanders RW, Hsu ST, van Anken E, Liscaljet IM, Dankers M, Bontjer I, Land A, Braakman I, Bonvin AM, Berkhout B.
Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.
Mol Biol Cell. 2008 Nov;19(11):4707-16.


OCT 2008

Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D, Su L.
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.
Blood. 2008 Oct 1;112(7):2858-68.
READ MORE: Of Mice and Men: Using “Humanized” Mice to Fight HIV

SEP 2008

Diaz-Griffero F, Perron M, McGee-Estrada K, Hanna R, Maillard PV, Trono D, Sodroski J.
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
Virology. 2008 Sep 1;378(2):233-42.

Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and psychometric assessment of a multidimensional measure of internalized HIV stigma in a sample of HIV-positive adults.
AIDS Behav. 2008 Sep;12(5):748-58.
READ MORE:  Measuring Stigma in HIV/AIDS


AUG 2008

Zhang L, Li X, Ma J, Yu L, Jiang J, Cen S.
The incorporation of APOBEC3 proteins into murine leukemia viruses.
Virology. 2008 Aug 15;378(1):69-78.

Mahajan AP, Sayles JN, Patel VA, Remien RH, Sawires SR, Ortiz DJ, Szekeres G, Coates TJ.
Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward.
AIDS. 2008 Aug;22 Suppl 2:S67-79.
READ MORE:  Stigma and the “Spoiled Identity”


JUL 2008

Jouvenet N, Bieniasz PD, Simon SM.
Imaging the biogenesis of individual HIV-1 virions in live cells.
Nature. 2008 Jul 10;454(7201):236-40.
READ MORE: Mathilde Krim Fellow Makes Breakthrough Finding - Podcast

Liu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y, Goepfert PA, Santiago ML, Ndjango JB, Neel C, Clifford SL, Sanz C, Kamenya S, Wilson ML, Pusey AE, Gross-Camp N, Boesch C, Smith V, Zamma K, Huffman MA, Mitani JC, Watts DP, Peeters M, Shaw GM, Switzer WM, Sharp PM, Hahn BH.
Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.
PLoS Pathog. 2008 Jul 4;4(7):e1000097.
READ MORE: Watch the Monkeys: Screening for New Retrovirus Outbreaks

Eggink D, Baldwin CE, Deng Y, Langedijk JP, Lu M, Sanders RW, Berkhout B.
Selection of T1249-resistant human immunodeficiency virus type 1 variants.
J Virol. 2008 Jul;82(13):6678-88.


JUN 2008

Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF.
Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.
J Virol. 2008 Jun;82(11):5548-61.

Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG.
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
J Virol. 2008 Jun;82(11):5398-407.

Unwalla HJ, Li H, Li SY, Abad D, Rossi JJ.
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.
Mol Ther. 2008 Jun;16(6):1113-9.
READ MORE: Attacking HIV Genetically


MAY 2008

Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM.
HIV-induced changes in T cell signaling pathways.
J Immunol. 2008 May 15;180(10):6490-500.
READ MORE: Dialing Down the T Cell

Des Jarlais DC.
Data and Public Health Decision Making on HIV Prevention in Injection Drug Users
J Urban Health. 2008 May; 85(3): 303–305.

Groot F, Welsch S, Sattentau QJ.
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
Blood. 2008 May 1;111(9):4660-3.


APR 2008

Chiu YL, Greene WC.
The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements.
Annu Rev Immunol. 2008 Apr;26:317-353.

Diaz-Griffero F, Taube R, Muehlbauer SM, Brojatsch J.
Efficient production of HIV-1 viral-like particles in mouse cells.
Biochem Biophys Res Commun. 2008 Apr 11;368(3):463-9.

Benferhat R, Sanchez-Martinez S, Nieva JL, Briand JP, Hovanessian AG.
The immunogenic CBD1 peptide corresponding to the caveolin-1 binding domain in HIV-1 envelope gp41 has the capacity to penetrate the cell membrane and bind caveolin-1.
Mol Immunol. 2008 Apr;45(7):1963-75.

Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau KL, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG.
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.
J Virol. 2008 Apr;82(8):4154-8.
READ MORE: Stopping Sexual Transmission of HIV

Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and Psychometric Assessment of a Multidimensional Measure of Internalized HIV Stigma in a Sample of HIV-positive Adults.
AIDS Behav. 2008 Apr 4.


MAR 2008

van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP.
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.
Nat Med. 2008 Mar;14(3):266-74.
READ MORE: Controlling HIV, Naturally


FEB 2008

Lakhashe S, Tripathy S, Paranjape R, Bhattacharya J.
Evidence of a Novel B/C Recombinant Exhibiting Unique Breakpoints of Near Full-Length HIV Type 1 Genome from Northeastern India.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):229-34.
READ MORE:  Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance

Troyer RM, Lalonde MS, Fraundorf E, Demers KR, Kyeyune F, Mugyenyi P, Syed A, Whalen CC, Bajunirwe F, Arts EJ.
A Radiolabeled Oligonucleotide Ligation Assay Demonstrates the High Frequency of Nevirapine Resistance Mutations in HIV Type 1 Quasispecies of NVP-Treated and Untreated Mother-Infant Pairs from Uganda.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):235-50.
READ MORE: Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance


JAN 2008

Zhang L, Saadatmand J, Li X, Guo F, Niu M, Jiang J, Kleiman L, Cen S.
Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradation.
Virology. 2008 Jan 5;370(1):113-21.
READ MORE: Man (and Woman) Versus Virus

Kerns JA, Emerman M, Malik HS.
Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.
PLoS Genet. 2008 Jan;4(1):e21.
READ MORE: Man (and Woman) Versus Virus  

2007 Publications

DEC 2007

Sawyer SL, Emerman M, Malik HS.
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals.
PLoS Pathog. 2007 Dec 21;3(12):e197

Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU, Lewin SR.
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.|
Blood. 2007 Dec 15;110(13):4161-4.
READ MORE: New Insights into HIV Latency: Identifying Roadblocks to a Cure 


NOV 2007

Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M Jr, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.
Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1
Drug Resistance in a Macaque Model for Antiretroviral Therapy
J. Virol. 2007;81 12145-12155

Chen P, Hübner W, Spinelli MA, Chen BK.
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.
J Virol. 2007 Nov;81(22):12582-95.

Hübner W, Chen P, Del Portillo A, Liu Y, Gordon RE, Chen BK.
Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1.
J Virol. 2007 Nov;81(22):12596-607.

CA McKnight, DC Des Jarlais, T Perlis, K Eigo, M Krim, M Ruiz, D Purchase, A Solberg, TD Mastro.
Syringe Exchange Programs --- United States, 2005.
MMWR, November 9, 2007 / 56(44);1164-1167.
READ MORE: Syringe Exchange Programs: A Key Component of HIV Prevention

Song C, Aiken C.
Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.
J Virol. 2007 Nov;81(21):11946-56.


OCT 2007

Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
EMBO J. 2007 Oct 3;26(19):4215-27.

Huffam S, Srasuebkul P, Zhou J, Calmy A, Saphonn V, Kaldor J, Ditangco R; on behalf of The TREAT Asia HIV Observational Database (TAHOD).
Prior antiretroviral therapy experience protects against zidovudine-related anaemia.
HIV Med. 2007 Oct;8(7):465-71.
READ MORE: Treating HIV/AIDS in Asia: Insights from amfAR's TREAT Asia Initiative

Voronin Y, Chohan B, Emerman M, Overbaugh J.
Primary isolates of human immunodeficiency virus type 1 are usually dominated by the major variants found in blood.
J Virol. 2007 Oct;81(19):10232-41.


SEP 2007

Roc AC, Ances BM, Chawla S, Korczykowski M, Wolf RL, Kolson DL, Detre JA, Poptani H.
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Arch Neurol. 2007 Sep;64(9):1249-57.
READ MORE: Scanning the Brain

Dames SA, Schönichen A, Schulte A, Barboric M, Peterlin BM, Grzesiek S, Geyer M.
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14312-14317

Gorry PR, McPhee DA, Verity E, Dyer WB, Wesselingh SL, Learmont J, Sullivan JS, Roche M, Zaunders JJ, Gabuzda D, Crowe SM, Mills J, Lewin SR, Brew BJ, Cunningham AL, Churchill MJ.
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo.
Retrovirology. 2007 Sep 23;4(1):66

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.
Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host.
J Immunol. 2007 Sep 1;179(5):3047-56.

Neil S.J.D, Sandrin V., Sundquist W.I., Bieniasz P.
An interferon-alpha induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by HIV-1 Vpu protein.
Cell Host & Microbe. (2007), Sep 2(3):193–203.

Simon Swingler, Angela M. Mann, Jin Zhou, Catherine Swingler, Mario Stevenson
Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein
PLoS Pathog 2007 3(9): e134

Srasuebkul P, Calmy A, Zhou J, Kumarasamy N, Law M, Lim PL.
Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in The TREAT Asia HIV Observational Database (TAHOD).
AIDS Res Ther. 2007 Sep 17;4(1):18


AUG 2007

Bellamy-McIntyre AK, Lay CS, Baär S, Maerz AL, Talbo GH, Drummer HE, Poumbourios P.
Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion.
J Biol Chem. 2007 Aug 10;282(32):23104-16.
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets

Pastore C, Nedellec R, Ramos A, Hartley O, Miamidian JL, Reeves JD, Mosier DE.
Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching.
J Virol. 2007 Aug;81(15):8165-79.
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets

Zhou J, Dore GJ, Zhang F, Lim PL, Chen YM; The TREAT Asia HIV Observational Database.
Hepatitis B and C virus coinfection in The TREAT Asia HIV Observational Database.
J Gastroenterol Hepatol. 2007 Aug 15;22(9):1510-1518.


JUL 2007

Berthoux L, Sebastian S, Muesing MA, Luban J.
The role of lysine 186 in HIV-1 integrase multimerization.
Virology. 2007 Jul 20;364(1):227-36.

Gray L, Churchill MJ, Sterjovski J, Witlox K, Learmont JC, Sullivan JS, Wesselingh SL, Gabuzda D, Cunningham AL, McPhee DA, Gorry PR.
Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source.
Virol J. 2007 Jul 16;4(1):75
READ MORE: Long-Term Survivors of HIV

Zhou J, Paton NI, Ditangco R; The TREAT Asia HIV Observational Database.
AIDS-defining illness diagnosed within 90 days after starting highly active antiretroviral therapy among patients from the TREAT Asia HIV Observational Database.
Int J STD AIDS. 2007 Jul;18(7):446-52.

Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
Identification of Human MVB12 Proteins as ESCRT-I Subunits that Function in HIV Budding.
Cell Host & Microbe 2007 Jul 2(1): 41-53


JUN 2007

Mowry EM, Woo JH, Ances BM.
Baló's concentric sclerosis presenting as a stroke-like syndrome.
Nat Clin Pract Neurol. 2007 Jun;3(6):349-54.

Sailaja G, Skountzou I, Quan FS, Compans RW, Kang SM.
Human immunodeficiency virus-like particles activate multiple types of immune cells.
Virology. 2007 Jun 5;362(2):331-41.
READ MORE: Envisioning an AIDS Vaccine

Coskun AK, van Maanen M, Janka D, Stockton D, Stankiewicsz P, Yatsenko S, Sutton RE.
Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release.
Virology. 2007 Jun 5;362(2):283-93.


MAY 2007

Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Virology. 2007 May 25;362(1):163-78.

Ellery PJ, Tippett E, Chiu YL, Paukovics G, Cameron PU, Solomon A, Lewin SR, Gorry PR, Jaworowski A, Greene WC, Sonza S, Crowe SM.
The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.
J Immunol. 2007 May 15;178(10):6581-9.
READ MORE: Uncovering New HIV Sanctuaries: Potential Roadblocks to a Cure


APR 2007

Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
J Virol. 2007 Apr;81(8):4033-43.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Law M, Cardoso RM, Wilson IA, Burton DR.
Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
J Virol. 2007 Apr;81(8):4272-85.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Huthoff H, Malim MH.
Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidation.
J Virol. 2007 Apr;81(8):3807-15.

Pohlmann S, Munch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Matz-Rensing K, Schneider T, Doms RW, Kirchhoff F.
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Virology. 2007 Apr 10;360(2):275-85.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Zhang L, Kovalev GI, Su L.
HIV-1 infection and pathogenesis in a novel humanized mouse model.
Blood. 2007 Apr 1;109(7):2978-81.


MAR 2007

Tempalski B, Flom PL, Friedman SR, Des Jarlais DC, Friedman JJ, McKnight C, Friedman R.
Social and political factors predicting the presence of syringe exchange programs in 96 US metropolitan areas.
Am J Public Health. 2007 Mar;97(3):437-47.

Fang L, Landau NR.
Analysis of Vif-induced APOBEC3G degradation using an alpha-complementation assay.
Virology. 2007 Mar 1;359(1):162-9.
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy

Schrofelbauer B, Hakata Y, Landau NR.
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4130-5.
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy


FEB 2007

Alfadhli A, Huseby D, Kapit E, Colman D, Barklis E.
Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer.
J Virol. 2007 Feb;81(3):1472-8.

Bieniasz PD.
An intrinsic host defense against HIV-1 integration?
J Clin Invest. 2007 Feb;117(2):302-4
READ MORE: Integrase: A New Word in the Fight Against HIV

Cardoso RM, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson IA.
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
J Mol Biol. 2007 Feb 2;365(5):1533-44.

Baek K, Brown RS, Birrane G, Ladias JA.
Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J Mol Biol. 2007 Feb 16;366(2):563-73.


JAN 2007

Mehandru S, Poles MA, Tenner-Racz K, Manuelli V, Jean-Pierre P, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection.
J Virol. 2007 Jan;81(2):599-612.

J Zhou, NI Paton, R Ditangco, Y-MA Chen, A Kamarulzaman, N Kumarasamy, CKC Lee, PCK Li, TP Merati, P Phanuphak, S Pujari, A Vibhagool, F Zhang, J Chuah, KR Frost, DA Cooper, MG Law, on behalf of The TREAT Asia HIV Observational Database.
Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database.
HIV Medicine 8 (1), 8-16.
READ MORE: Treating HIV in Asia: Lessons from amfAR's TREAT Asia Program


2006 Publications

DEC 2006

Hakata Y, Landau NR.
Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. J Biol Chem. 2006 Dec 1;281(48):36624-31.

Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection.
PLoS Med. 2006 Dec 5;3(12):e484
READ MORE: The HAART—and Gut—Of Acute HIV Infection

Zhou J, Phanupak P, Kiertiburanakul S, Ditangco R, Kamarulzaman A, Pujary S; TREAT Asia HIV Observational Database.
Highly active antiretroviral treatment containing efavirenz or nevirapine and related toxicity in the TREAT Asia HIV Observational Database.
J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):501-3.


NOV 2006

Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS.
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol. 2006 Nov;13(11):1223-30.
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update

Kornbluth RS, Stone GW.
Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J Leukoc Biol. 2006 Nov;80(5):1084-102.
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update

Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants. Antimicrob Agents Chemother. 2006 Nov;50(11):3607-14.


OCT 2006

Ances BM, Letendre S, Buzzell M, Marquie-Beck J, Lazaretto D, Marcotte TD, Grant I, Ellis RJ; HNRC Group.
Valproic acid does not affect markers of human immunodeficiency virus disease progression.
J Neurovirol. 2006 Oct;12(5):403-6.

Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC.
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition.
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15588-93.
READ MORE: Host Resistance Factors Preventing HIV Infection

Hatziioannou T, Princiotta M, Piatak M Jr, Yuan F, Zhang F, Lifson JD, Bieniasz PD.
Generation of simian-tropic HIV-1 by restriction factor evasion.
Science. 2006 Oct 6;314(5796):95.
READ MORE: Host Resistance Factors Preventing HIV Infection

Alimonti JB, Kimani J, Matu L, Wachihi C, Kaul R, Plummer FA, Fowke KR.
Characterization of CD8 T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya.
Immunol Cell Biol. 2006 Oct;84(5):482-5.


SEP 2006

Holy A.
Antiviral acyclic nucleoside phosphonates structure activity studies.
Antiviral Res. 2006 Sep;71(2-3):248-53.
READ MORE: Designer Drugs For HIV

Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL.
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA.
Chem Biol. 2006 Sep;13(9):993-1000.
READ MORE: Designer Drugs For HIV


AUG 2006

Des Jarlais DC, Sloboda Z, Friedman SR, Tempalski B, McKnight C, Braine N.
Diffusion of the D.A.R.E and syringe exchange programs.
Am J Public Health. 2006 Aug;96(8):1354-8.

Valente ST, Goff SP.
Inhibition of HIV-1 gene expression by a fragment of hnRNP U.
Mol Cell. 2006 Aug;23(4):597-605.


JUL 2006

Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR.
Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
J Virol. 2006 Jul;80(13):6324-32
READ MORE: HIV and the Brain

Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Jul 20;351(1):226-36.


JUN 2006

Barron MA, Blyveis N, Pan SC, Wilson CC.
Human Dendritic Cell Interactions with Whole Recombinant Yeast: Implications for HIV-1 Vaccine Development.
J Clin Immunol. 2006 May 13.

Bhattacharya J, Repik A, Clapham PR.
Gag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes.
J Virol. 2006 Jun;80(11):5292-300.
READ MORE: Identifying Vulnerabilities in HIV as New Drug Targets

Schrofelbauer B, Senger T, Manning G, Landau NR.
Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3G.
J Virol. 2006 Jun;80(12):5984-91.


MAY 2006

Anand AR, Ganju RK.
HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.
J Biol Chem. 2006 May 5;281(18):12289-99.
READ MORE: Exploring How HIV Kills Cells of the Immune System


APR 2006

Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Apr 19. [Epub ahead of print]
READ MORE: The Challenge of Drug-Resistant HIV

Coskun AK, van Maanen M, Nguyen V, Sutton RE.
Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.
J Virol. 2006 Apr;80(7):3406-15.
READ MORE: Fighting HIV with Genetics


MAR 2006

Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH.
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.
J Virol. 2006 Mar;80(5):2578-81.

Chiu YL, Greene WC.
APOBEC3 Cytidine Deaminases: Distinct Antiviral Actions along the Retroviral Life Cycle.
J Biol Chem. 2006 Mar 31;281(13):8309-12.

Chen H, Lilley CE, Yu Q, Lee DV, Chou J, Narvaiza I, Landau NR, Weitzman MD.
APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.
Curr Biol. 2006 Mar 7;16(5):480-5.

Saphire AC, Gallay PA, Bark SJ.
Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins.
J Proteome Res. 2006 Mar;5(3):530-8.


FEB 2006

Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE.
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
J Virol. 2006 Feb;80(4):1680-7.
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine

Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS.
Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines.
J Virol. 2006 Feb;80(4):1762-72.
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine

JAN 2006

Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J.
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.
Nature. 2006 Jan 5;439(7072):89-94.
READ MORE: A Novel Strategy Against Sexually Transmitted Infections

2005 Publications

DEC 2005

Alfadhli A, Dhenub TC, Still A, Barklis E.
Analysis of human immunodeficiency virus type 1 Gag dimerization-induced assembly.
J Virol. 2005 Dec;79(23):14498-506. 

Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
EMBO J. 2005 Dec 21;24(24):4291-303.

Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.
Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.
Nucleic Acids Res. 2005 Dec 23;33(22):7000-10.

Perez-Caballero D, Hatziioannou T, Zhang F, Cowan S, Bieniasz PD.
Restriction of Human Immunodeficiency Virus Type 1 by TRIM-CypA Occurs with Rapid Kinetics and Independently of Cytoplasmic Bodies, Ubiquitin, and Proteasome Activity
J Virol. 2005 Dec;79(24):15567-72.

Hsu M, Ho S, Balfe P, Gettie A, Harouse J, Blanchard J, Cheng-Mayer C.
A CCR5-Tropic Simian-HIV Molecular Clone Capable of Inducing AIDS in Rhesus Macaques.
JAIDS. 2005 Dec 1; 40(4):383-387.

Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC.
"Wide-Open" 1.3 A Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target.
Structure (Camb). 2005 Dec;13(12):1887-1895.

Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK.
Transgenic plant production of Cyanovirin-N, an HIV microbicide.
FASEB J. 2005 Dec 14;
READ MORE: Using Tobacco to Prevent HIV

Voronin Y, Overbaugh J, Emerman M.
Simian immunodeficiency virus variants that differ in pathogenicity differ in fitness under rapid cell turnover conditions.
J Virol. 2005 Dec;79(24):15091-8.


NOV 2005

Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE Jr, Fink A, Gilmore GT, Staley C, Ward A, Ali O, Binderow S, Cohen S, Grohskopf LA, Paxton L, Hart CE, Dezzutti CS.
A Human Colorectal Explant Culture to Evaluate Topical Microbicides for the Prevention of HIV Infection.
J Infect Dis. 2005 Nov 1;192(9):1545-56.


OCT 2005

Berthoux L, Sebastian S, Sokolskaja E, Luban J.
Cyclophilin A is required for TRIM5alpha-mediated resistance to HIV-1 in Old World monkey cells.
PNAS. 2005 Oct 11; 102(41):14849-14853.

Selvarajah S, Puffer B, Pantophlet R, Law M, Doms RW, Burton DR.
Comparing antigenicity and immunogenicity of engineered gp120.
J Virol. 2005 Oct;79(19):12148-63.

Arien KK, Troyer RM, Gali Y, Colebunders RL, Arts EJ, Vanham G.
Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time.
AIDS. 2005 Oct 14;19(15):1555-1564.
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time


SEP 2005

Barboric M, Zhang F, Besenicar M, Plemenitas A, Peterlin BM.
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation.
J Virol. 2005 Sep;79(17):11135-41.

Reeves JD, Piefer AJ.
Emerging drug targets for antiretroviral therapy.
Drugs. 2005;65(13):1747-66.


AUG 2005

Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, Francois-Bongarcon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P.
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.
Blood. 2005 Aug 1;106(3):818-26. Epub 2005 Apr 14.

Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. Epub 2005 Aug 4


JUL 2005

Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Jul 1;280(26):24968-77.

Balasubramanian A, Koziel M, Groopman J, Ganju RK.
Molecular mechanism of hepatic injury in coinfection with hepatitis C virus and HIV.
Clin. Infect. Dis. 2005 Jul 1;41(Suppl 1):S32-37.

Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD.
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.
J Virol. 2005 Jul;79(14):8969-78.

Troyer RM, Collins KR, Abraha A, Fraundorf E, Moore DM, Krizan RW, Toossi Z, Colebunders RL, Jensen MA, Mullins JI, Vanham G, Arts EJ.
Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression.
J Virol. 2005 Jul;79(14):9006-18.
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time


JUN 2005

Berthoux L, Sebastian S, Sayah DM, Luban J.
Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Virol. 2005 Jun;79(12):7883-8.

Senkovich O, Speed H, Grigorian A, Bradley K, Ramarao CS, Lane B, Zhu G, Chattopadhyay D.
Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum.
Biochim Biophys Acta. 2005 Jun 10;

Marozsan AJ, Moore DM, Lobritz MA, Fraundorf E, Abraha A, Reeves JD, Arts EJ.
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry.
J Virol. 2005 Jun;79(11):7121-34.


MAY 2005

Huseby D, Barklis RL, Alfadhli A, Barklis E.
Assembly of human immunodeficiency virus precursor gag proteins.
J Biol Chem. 2005 May 6;280(18):17664-70.

Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC.
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.
Nature. 2005 May 5;435(7038):108-14. Epub 2005 Apr 13.

Ylisastigui L, Kaur R, Johnson H, Volker J, He G, Hansen U, Margolis D.
Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter.
J Virol. 2005 May;79(10):5952-62.

Smith AJ, Meyer PR, Asthana D, Ashman MR, Scott WA.
Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.
Antimicrob Agents Chemother. 2005 May;49(5):1761-9.


APR 2005

Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Apr 25;

Dolakova P, Holy A, Zidek Z, Masojidkova M, Kmonickova E.
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorg Med Chem. 2005 Apr 1;13(7):2349-54.

Ibarrondo FJ, Anton PA, Fuerst M, Ng HL, Wong JT, Matud J, Elliott J, Shih R, Hausner MA, Price C, Hultin LE, Hultin PM, Jamieson BD, Yang OO.
Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infection.
J Virol. 2005 Apr;79(7):4289-97.

Reeves JD, Lee FH, Miamidian JL, Jabara CB, Juntilla MM, Doms RW.
Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.
J Virol. 2005 Apr;79(8):4991-9.


MARCH 2005

Chung E, Amrute SB, Abel K, Gupta G, Wang Y, Miller CJ, Fitzgerald-Bocarsly P.
Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque.
Clin Diagn Lab Immunol. 2005 Mar;12(3):426-35.

Navarro F, Bollman B, Chen H, Konig R, Yu Q, Chiles K, Landau NR.
Complementary function of the two catalytic domains of APOBEC3G.
Virology. 2005 Mar 15;333(2):374-86.


FEB 2005

Barboric M, Peterlin B.M.
A New Paradigm in Eukaryotic Biology: HIV Tat and the Control of Transcriptional Elongation.
PloS Biol. 3(2): e76

Cardoso RM, Zwick MB, Stanfield RL, Kunert R, Binley JM, Katinger H, Burton DR, Wilson IA.
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41.
Immunity. 2005 Feb;22(2):163-73.
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Structure of an unliganded simian immunodeficiency virus gp120 core.
Nature. 2005 Feb 24;433(7028):834-41.
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein.
Structure (Camb). 2005 Feb;13(2):197-211.

Lenz O, Dittmar MT, Wagner A, Ferko B, Vorauer-Uhl K, Stiegler G, Weissenhorn W.
Trimeric Membrane-anchored gp41 Inhibits HIV Membrane Fusion.
J Biol Chem. 2005 Feb 11;280(6):4095-4101. Epub 2004 Dec 1.

Zhou J, Kumarasamy N, Ditangco R, Kamarulzaman A, Lee CK, Li PC, Paton NI, Phanuphak P, Pujari S, Vibhagool A, Wong WW, Zhang F, Chuah J, Frost KR, Cooper DA, Law MG; TREAT Asia HIV Observational Database.
The TREAT Asia HIV Observational Database: baseline and retrospective data.
J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):174-9.


JAN 2005

Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.

Alimonti JB, Koesters SA, Kimani J, Matu L, Wachihi C, Plummer FA, Fowke KR.
CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women.
J Infect Dis. 2005 Jan 1;191(1):20-4. Epub 2004 Dec 01.

Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD.
Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.
J Virol. 2005 Jan;79(1):176-83.

Hill M, Tachedjian G, Mak J.
The packaging and maturation of the HIV-1 Pol proteins.
Curr HIV Res. 2005 Jan;3(1):73-85.

*****Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.

2004 Publications

DEC 2004

Albright AV, Gonzalez-Scarano F.
Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression.
J Neuroimmunol. 2004 Dec;157(1-2):27-38.

Ambrose Z, Boltz V, Palmer S, Coffin JM, Hughes SH, Kewalramani VN.
In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.
J Virol. 2004 Dec;78(24):13553-61.

Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D.
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.
Genes Dev. 2004 Dec 1;18(23):2861-6.

De Berardinis P, Haigwood NL.
New recombinant vaccines based on the use of prokaryotic antigen-display systems.
Expert Rev Vaccines. 2004 Dec;3(6):673-9.

Yu Q, Chen D, Konig R, Mariani R, Unutmaz D, Landau NR.
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
J Biol Chem. 2004 Dec 17;279(51):53379-86. Epub 2004 Oct 04.

Francois-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J.
Cross-Clade CD8 T-Cell Responses to HIVIIIB and Chinese B' and C/B' Viruses in North American and Chinese HIV-Seropositive Donors.
J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1435-1444.


NOV 2004

Zerhouni B, Nelson JA, Saha K.
CXCR4-dependent infection of CD8+, but not CD4+, lymphocytes by a primary human immunodeficiency virus type 1 isolate.
J Virol. 2004 Nov;78(22):12288-96.


OCT 2004

Khan MZ, Brandimarti R, Patel JP, Huynh N, Wang J, Huang Z, Fatatis A, Meucci O.
Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.
AIDS Res Hum Retroviruses. 2004 Oct;20(10):1063-71.

Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.
J Biol Chem. 2004 Oct 29;279(44):45389-98. Epub 2004 Aug 11.

Pantophlet R, Wilson IA, Burton DR.
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12.
Protein Eng Des Sel. 2004 Oct;17(10):749-58.