Cure – Describing the Reservoir

Cure — Describing the Reservoir

The main barrier to a cure for HIV is the reservoir of persistent virus that remains dormant in both blood and tissue, beyond the reach of antiretroviral therapy and the immune system. Researchers are working to resolve key questions, such as how to activate HIV-infected reservoir cells, how to make them vulnerable to attack by the immune system, and how to eradicate them altogether.

Mapping a Moving Target


Timing Is Everything


Importance of the Brain as an HIV Reservoir

How Does the HIV Reservoir Avoid Destruction?

Mapping a Moving Target

Early Treatment No Barrier to Reservoir Formation

Footprints, Signatures, and Survival Factors

Curing HIV: The Road Ahead


A Step Toward Eliminating Reservoir Cells?

Dismantling HIV Silencing Factors

Using PET Scans to Visualize HIV

Defining Targets for Eradicating Latent HIV Reservoirs

The Not-So-Latent Reservoir

When U.S.-Based Studies Don’t Measure Up

Tracing the Unique Immune Footprints of Elite Controllers


Predicting Post-Treatment Control Before It Happens


Mining the Blood for Markers of the Reservoir

The Past, Present, and Future of HIV Reservoir Cells

Molecular Pathways to an HIV Cure

New Study Takes Deep Dive into Elite Control

Does ART Adequately Reach Tissue Reservoirs of HIV?

Probing the Provirus

Biomarkers May Point to Post-Treatment Control