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Research News 5

Research News

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  • Tracing the Unique Immune Footprints of Elite Controllers

    Researchers study the mechanisms that enable a small group of people to naturally suppress HIV.

  • Can Long-Term Treatment Lead to ART-Free Control of HIV?

    Background In early December 2021, amfAR convened a think tank of 15 researchers to address this tantalizing possibility. The question follows on the heels of a number of recent findings made by Drs. Xu Yu of the Ragon Institute of MGH, MIT and Harvard, and Mathias Lichterfeld of Brigham and Women’s Hospital in Boston, who…

  • Stem Cell Transplants and the CCR5 Mutation

    Interrupting antiretroviral therapy (ART) after stem cell transplant using donor cells lacking CCR5 mutation can lead to acute complications from HIV rebound.

  • Researchers Report New Case of Spontaneous HIV Cure

    A woman in Argentina has become only the second documented person whose own immune system appears to have cured her of HIV.

  • Keeping Dormant HIV Dormant

    Researchers aim to find out if safe and effective drugs can be developed to permanently suppress the HIV reservoir.

  • Why Do Some Elite Controllers Stop Controlling HIV?

    A small minority of people living with HIV can suppress their viral load to levels at which the risk of HIV transmission and disease development are very low—all in the absence of antiretroviral therapy.

  • Another HIV Vaccine Failure – What HIV and COVID Can Teach Each Other

    At the end of the roughly four-year study, there were no significant differences in HIV acquisition between those who received the vaccine and those who got placebo.  

  • A Promising, “Unusual” Approach to Targeting HIV Spike Protein

    A series of monoclonal antibodies were generated from rabbits immunized with a chemically stabilized form of the gp120/gp41 trimer.

  • amfAR Grants Explore Gene Therapy Approaches to HIV Cure

    Newly funded research teams deploy powerful CRISPR gene-editing and CAR T cell strategies to home in on HIV reservoir, the main barrier to a cure.

  • Predicting Post-Treatment Control Before It Happens

    Dr. Mohamed Abdel-MohsenThere is a pressing need for identification of blood tests that could help predict the likelihood of HIV remission after stopping antiretroviral therapy (ART) in the setting of HIV cure trials.

  • Mimicking CD4: A Bait and Switch Approach to Immunotherapy

    This month we focus on another form of immunotherapy, also with the potential to facilitate eradication of HIV reservoirs as part of an HIV cure strategy.

  • CAR Cells, Revved Up

    hen sought to determine if those cells could be enhanced with improvements on three fronts: 1) an increased ability to differentiate into mature, HIV-fighting cells; 2) enhanced resistance to infection and destruction by HIV; and 3) with improved anti-HIV capabilities.   

  • HIV Research: Paving the Way to COVID Vaccines

    The extraordinarily rapid development of these COVID vaccines…was possible because the foundational work had already been done – by AIDS researchers.

  • Reversing HIV Latency and Decreasing the Viral Reservoir: Clues from Cancer

    Research Question HIV persists in a dormant state primarily in T cells expressing surface proteins known as immune checkpoint (IC) molecules. These surface molecules normally act as brakes that prevent an overly reactive immune response. In the setting of HIV, ICs might hamper efforts to cure by keeping the virus in immune cells in a…

  • Two Krim Fellows Awarded

    amfAR awarded Krim Fellowships to Aleksandar Antanasijevic and Ujjwal Rathore, who will harness powerful technologies in support of an HIV vaccine and cure.

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