Research News 5
Exploring Cell Proteins That Block HIV
Research Question Evolution has insured that many mammals—from mice to humans—have cell proteins that can prevent infection by certain viruses, including HIV. One of the most potent of these proteins, identified two decades ago, is APOBEC3G. Unfortunately for humans, HIV has evolved protection—a viral protein that prevents APOBEC3G from attacking HIV in humans, though not […]
How Does the Immune System Recover After a Stem Cell Transplant?
Based on a small number of patients, “highlights how little we know about the clinical course post-transplant for HIV-positive persons,” arguing for more research focused on this population.
Why Do HIV Reservoirs Persist After Stem Cell Transplants?
Researchers studied 16 HIV-positive individuals on ART who underwent stem cell transplants.
Does ART Adequately Reach Tissue Reservoirs of HIV?
This may contribute to the persistence of HIV reservoirs and viral rebound during analytic treatment interruption.
Probing the Provirus
The decrease in intact provirus could suggest that despite potent ART, the immune system might be able to differentiate between cells infected with intact provirus and those with defective provirus.
New Methods to Reverse HIV Latency
Immune checkpoint blockade is “an attractive option” to move into the clinic, as both a potential method of reversing the latent state of HIV and a strategy to boost T cell activity against HIV.
Biomarkers May Point to Post-Treatment Control
Finding biomarkers that can predict post-treatment control without the need for treatment interruption is a priority for the HIV cure field, not least because this could help protect partners from unnecessary exposure to the virus.
amfAR Researchers Unable to Find HIV In London Transplant Patient
A stem cell transplant patient from London has not experienced a rebound of his HIV during the past 18 months off antiretroviral therapy (ART).
Dr. Mathilde Krim to Be Represented in the National Portrait Gallery
In recognition of her leadership in the fight against HIV/AIDS, the National Portrait Gallery has accepted two photographic portraits of amfAR Founding Chairman Dr. Mathilde Krim into its permanent collection.
Testing “Shock and Kill”
The study presented here suggests that ‘shock and kill’ strategies with drugs such as disulfiram will likely require another step to prime the immune system to clear virus-producing T cell
Bringing Science to Bear: Questions for Mathilde Krim, Ph.D., amfAR Founding Chairman
From day one, we decided to deal with the fundamental aspects of the AIDS problem.
AIDS at 30: A Relentless Search for Answers
A brief report on five gay men in Los Angeles with a rare and deadly form of pneumonia, published on June 5, 1981, sparked an ominous flash of recognition in a number of physicians and researchers in New York City. They, too, were seeing such cases: young, previously healthy patients, nearly all gay men, who […]
January 2008: amfAR Announces Inaugural Mathilde Krim Fellowship Awards for AIDS Research
amfAR, the Foundation for AIDS Research, has announced that it will award more than $1 million in the inaugural round of Mathilde Krim Fellowships in Basic Biomedical Research.