Cure—Testing in the lab
Cure — Preclinical Testing
Before testing an agent or therapeutic approach in human subjects, researchers first need to show proof of concept or characterize how the agent behaves in vitro—in the laboratory. amfAR-funded researchers are testing a variety of approaches, such as boosting the immune system, gene therapy, and CAR T cells, which have proven highly successful in the treatment of certain types of cancer.
Prof. Sharon Lewin, Director of the Peter Doherty Institute for Infection and Immunity, University of Melbourne (Photo courtesy The Doherty Institute)
2025
Researchers Target and Awaken Dormant HIV in Groundbreaking Advance
Refining Anti-HIV Gene Therapies
Boosting Cellular Defense Mechanisms
2024
Inhibiting HIV by Host Cell Targeting Strategies
Predicting Changes in the HIV Reservoir
Creating a Cost-Effective Cure
What’s the Role of Natural Killer Cells in Curing HIV?
2023
Overcoming Toxicities Associated with Virus-Based Gene Therapy
Combining CAR T Cell Strategies to Achieve an HIV Cure
In Transplant-Driven Cures, What’s in Play Beyond the CCR5 Mutation?
2022
Improving HIV Latency-Reversing Strategies
A Pathway to Controlling Inflammation?
Has the “Shock and Kill” Approach Been Revived?
2021
Mimicking CD4: A Bait and Switch Approach to Immunotherapy
Immunotherapy Targeting HIV Reservoirs
2020
HIV Reservoirs in the Blood and Gut Respond Differently to Virus Activators