Cure—Testing in the lab

Cure — Preclinical Testing

Before testing an agent or therapeutic approach in human subjects, researchers first need to show proof of concept or characterize how the agent behaves in vitro—in the laboratory. amfAR-funded researchers are testing a variety of approaches, such as boosting the immune system, gene therapy, and CAR T cells, which have proven highly successful in the treatment of certain types of cancer.


Creating a Cost-Effective Cure

What’s the Role of Natural Killer Cells in Curing HIV?


Overcoming Toxicities Associated with Virus-Based Gene Therapy

Combining CAR T Cell Strategies to Achieve an HIV Cure

In Transplant-Driven Cures, What’s in Play Beyond the CCR5 Mutation?


Improving HIV Latency-Reversing Strategies

A Pathway to Controlling Inflammation?

Has the “Shock and Kill” Approach Been Revived?


Keeping Dormant HIV Dormant

Mimicking CD4: A Bait and Switch Approach to Immunotherapy

CAR Cells, Revved Up

Immunotherapy Targeting HIV Reservoirs


HIV Reservoirs in the Blood and Gut Respond Differently to Virus Activators

New Methods to Reverse HIV Latency