Research News 6

Research News

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  • Mimicking CD4: A Bait and Switch Approach to Immunotherapy

    This month we focus on another form of immunotherapy, also with the potential to facilitate eradication of HIV reservoirs as part of an HIV cure strategy.

  • CAR Cells, Revved Up

    hen sought to determine if those cells could be enhanced with improvements on three fronts: 1) an increased ability to differentiate into mature, HIV-fighting cells; 2) enhanced resistance to infection and destruction by HIV; and 3) with improved anti-HIV capabilities.   

  • HIV Research: Paving the Way to COVID Vaccines

    The extraordinarily rapid development of these COVID vaccines…was possible because the foundational work had already been done – by AIDS researchers.

  • Reversing HIV Latency and Decreasing the Viral Reservoir: Clues from Cancer

    Research Question HIV persists in a dormant state primarily in T cells expressing surface proteins known as immune checkpoint (IC) molecules. These surface molecules normally act as brakes that prevent an overly reactive immune response. In the setting of HIV, ICs might hamper efforts to cure by keeping the virus in immune cells in a…

  • Two Krim Fellows Awarded

    amfAR awarded Krim Fellowships to Aleksandar Antanasijevic and Ujjwal Rathore, who will harness powerful technologies in support of an HIV vaccine and cure.

  • Risks and Potential Benefits of Participating in Cure Research

    Perceptions of cure trial participants concerning personal and community risks and benefits are relevant to such studies and have received little attention. 

  • Immunotherapy Targeting HIV Reservoirs

    Research Question CAR T cell therapy, which uses T cells that have been engineered to target specific proteins, has revolutionized the treatment of some blood cancers. Yet success in HIV has lagged and several challenges remain. For example, how can we ensure that the CAR T cells go to the areas where they are needed?…

  • New amfAR Grants Target Intersection HIV and COVID-19

    amfAR Fund to Fight COVID-19 researchers investigate “long-haulers” and the effect of coronavirus on the HIV reservoir, the main barrier to a cure.

  • Remembering Dr. Joseph Sonnabend, Early Pioneer on AIDS

    Dr. Sonnabend was a co-founder of the AIDS Medical Foundation, amfAR’s predecessor.

  • Prospects for an HIV/AIDS Cure: Opinions of People with HIV and Their Healthcare Providers

    The authors concluded that educational strategies tailored specifically to each group are required to increase understanding of HIV cure research and the role of ATI.

  • amfAR Invests in “Next Generation” HIV Cure Intervention

    Newly funded amfAR grantee Dr. Jerome Zack borrows from cancer research by investigating modified natural killer CAR-T cells to cure HIV.

  • Mining the Blood for Markers of the Reservoir

    The authors concluded that “the development of these tools may represent simple biomarkers for the rapid evaluation of changes in viral replication outside of the blood and changes in the reservoir size.”

  • HIV Reservoirs in the Blood and Gut Respond Differently to Virus Activators

    The authors conclude that “it will be critical to evaluate the efficacy of LRAs in both blood and tissues” in order to develop more effective therapeutics in HIV cure strategies.

  • The Past, Present, and Future of HIV Reservoir Cells

    Research Question The HIV reservoir consists of HIV-infected cells that are difficult to characterize because to date they have been indistinguishable from uninfected cells. Once the HIV inside infected cells is activated, many of the surface and interior characteristics change. While activated reservoir cells are easier to identify and isolate from blood samples, these fundamental…

  • A Conversation with the San Francisco Patient

    Loreen Willenberg is an elite controller (EC) – one of the rare individuals who control HIV infection without antiretroviral therapy. ECs were recently described in new and unprecedented detail in the prestigious journal Nature. Loreen was among the ECs the researchers studied. For all intents and purposes, she may be considered “cured” of HIV. Loreen…

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